Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases

Detalhes bibliográficos
Autor(a) principal: Chenou, Francine
Data de Publicação: 2019
Outros Autores: Azevedo, Jailton, Leal, Helena Ferreira, Gonçalves, Marilda de Souza, Reis, Joice Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39351
Resumo: Foundation for the State of Bahia (FAPESB-PP-SUS0001/2009)
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spelling Chenou, FrancineAzevedo, JailtonLeal, Helena FerreiraGonçalves, Marilda de SouzaReis, Joice Neves2020-01-21T13:44:11Z2020-01-21T13:44:11Z2019CHENOU, Francine et al. Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases. Hematology, Transfusion and Cell Therapy, v. 42, n. 2, p. 139-144, 20 Sept. 2019.2531-1379https://www.arca.fiocruz.br/handle/icict/3935110.1016/j.htct.2019.06.006Foundation for the State of Bahia (FAPESB-PP-SUS0001/2009)National Council for Scientific and Techno-logical Development (CNPq – 400005/2013-1)Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Sickle cell anemia (SCA) is a common genetic blood disorder, affecting millions worldwide. According to current evidence, individuals with SCA have more than 300 times greater risk to develop bacterial meningitis (BM) than the general population. Herein we have described the characteristics of a series of BM cases in SCA patients in Salvador, Brazil, during 13 years of hospital-based surveillance. Data on clinical presentation, laboratory parameters and outcomes were collected retrospectively by reviewing medical records. From 1999 to 2011, ten SCA patients were identified among the 2511 cases of BM (10/2511; 0.40%). These patients were more likely to be male (90%) and to be younger (median age 8.5 years). The causative agents were Streptococcus pneumoniae (n=5) and Haemophilus influenzae (n=1). The most frequent pneumococcal serotypes were 23F (2 cases), 14, 18F, 23B (one case each). Common medical complications were stroke (n=3); heart failure (n=2), respiratory problems (n=2), renal dysfunctions (n=2) and leg ulcers (n=1). This study highlights the importance of S. pneumoniae as a causative agent of meningitis in individuals with SCA and shows the diversity of comorbidities associated with this condition.engElsevierMeningite bacterianaAnemia falciformeS. PneumoniaeH. influenzaeBacterial meningitisSickle cell anemiaS. PneumoniaeH. influenzaeaBacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten casesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39351/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALChenou F Bacterial meningitis Hematol Transf Cell Ther.pdfChenou F Bacterial meningitis Hematol Transf Cell Ther.pdfapplication/pdf502255https://www.arca.fiocruz.br/bitstream/icict/39351/2/Chenou%20F%20Bacterial%20meningitis%20Hematol%20Transf%20Cell%20Ther.pdf2898f5f32342eddfa10f9b550d7bee71MD52TEXTChenou F Bacterial meningitis Hematol Transf Cell Ther.pdf.txtChenou F Bacterial meningitis Hematol Transf Cell Ther.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
title Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
spellingShingle Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
Chenou, Francine
Meningite bacteriana
Anemia falciforme
S. Pneumoniae
H. influenzae
Bacterial meningitis
Sickle cell anemia
S. Pneumoniae
H. influenzaea
title_short Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
title_full Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
title_fullStr Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
title_full_unstemmed Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
title_sort Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases
author Chenou, Francine
author_facet Chenou, Francine
Azevedo, Jailton
Leal, Helena Ferreira
Gonçalves, Marilda de Souza
Reis, Joice Neves
author_role author
author2 Azevedo, Jailton
Leal, Helena Ferreira
Gonçalves, Marilda de Souza
Reis, Joice Neves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Chenou, Francine
Azevedo, Jailton
Leal, Helena Ferreira
Gonçalves, Marilda de Souza
Reis, Joice Neves
dc.subject.other.pt_BR.fl_str_mv Meningite bacteriana
Anemia falciforme
S. Pneumoniae
H. influenzae
topic Meningite bacteriana
Anemia falciforme
S. Pneumoniae
H. influenzae
Bacterial meningitis
Sickle cell anemia
S. Pneumoniae
H. influenzaea
dc.subject.en.pt_BR.fl_str_mv Bacterial meningitis
Sickle cell anemia
S. Pneumoniae
H. influenzaea
description Foundation for the State of Bahia (FAPESB-PP-SUS0001/2009)
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-01-21T13:44:11Z
dc.date.available.fl_str_mv 2020-01-21T13:44:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CHENOU, Francine et al. Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases. Hematology, Transfusion and Cell Therapy, v. 42, n. 2, p. 139-144, 20 Sept. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39351
dc.identifier.issn.pt_BR.fl_str_mv 2531-1379
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.htct.2019.06.006
identifier_str_mv CHENOU, Francine et al. Bacterial meningitis in patients with sickle cell anemia in Salvador, Bahia, Brazil: a report on ten cases. Hematology, Transfusion and Cell Therapy, v. 42, n. 2, p. 139-144, 20 Sept. 2019.
2531-1379
10.1016/j.htct.2019.06.006
url https://www.arca.fiocruz.br/handle/icict/39351
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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