Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15224 |
Resumo: | ACTG PEARLS and NWCS 319 Study Team |
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Mave, VidyaErlandson, Kristine MGupte, NikhilBalagopal, AshwinAsmuth, David MCampbell, Thomas BSmeaton, LauraKumarasamy, NagalingeswaranHakim, JamesSantos, BrenoRiviere, CynthiaHosseinipour, Mina CSugandhavesa, PatcharaphanInfante, RosaPillay, SandyCardoso, Sandra WagnerTripathy, SrikanthMwelase, NoluthandoBerendes, SimaAndrade, Bruno de BezerrilThomas, David LBollinger, Robert CGupta, Amita2016-08-10T14:12:08Z2016-08-10T14:12:08Z2016MAVE, V. et al. Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults. • Journal of Infectious Diseases, v. 214, p. 65-72, 2016.0022-1899https://www.arca.fiocruz.br/handle/icict/1522410.1093/infdis/jiw096ACTG PEARLS and NWCS 319 Study TeamJohns Hopkins University-BJ. Medical College Clinical Research Site. Pune, India / Johns Hopkins University. Division of Infectious Diseases. Baltimore, MarylandUniversity of Colorado Denver. Department of Medicine. Denver, AuroraJohns Hopkins University-BJ. Medical College Clinical Research Site. Pune, India / Johns Hopkins University. Division of Infectious Diseases. Baltimore, MarylandJohns Hopkins University. Division of Infectious Diseases. Baltimore, MarylandUniversity California Davis. Department of Medicine. Sacramento, USAUniversity of Colorado Denver. Department of Medicine. Denver, AuroraHarvard T. H. Chan School of Public Health. Boston, MassachusettsY. R. Gaitonde Center for AIDS Research and Education. Chennai, IndiaUniversity of Zimbabwe. HarareHospital Nossa Senhora de Conceição. Porto Alegre, RS, BrasilLes Centres GHESKIO. Port-Au-Prince, HaitiUniversity of North Carolina Project. Lilongwe, MalawiResearch Institute for Health Sciences. Chiang Mai, ThailandIMPACTA Peru. San MiguelDurban University of Technology. Durban International Clinical Research Site. South AfricaFundacao Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. STD/AIDS Clinical Research Laboratory. Rio de Janeiro, RJ, BrasilNational AIDS Research Institute. Pune, IndiaUniversity of Witwatersrand. Department of Medicine. Johannesburg, South AfricaMalawi College of Medicine-Johns Hopkins University Research Project. Blantyre / Liverpool School of Tropical Medicine. United KingdomFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, BrasilFundação José Silveira. Instituto Brasileiro para a Investigação da Tuberculose. Salvador, BA, BrasilJohns Hopkins University. Division of Infectious Diseases. Baltimore, MarylandJohns Hopkins University. Division of Infectious Diseases. Baltimore, MarylandJohns Hopkins University-BJ. Medical College Clinical Research Site. Pune, India / Johns Hopkins University. Division of Infectious Diseases. Baltimore, MarylandBackground. Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods. Among a random virologically suppressed participants of the Prospective Evaluation of Antiretrovirals in Resource- Limited Settings trial, inflammatory markers were measured at weeks 0, 24, and 48 after antiretroviral therapy (ART) initiation. Associations between both baseline and change in body mass index (BMI; calculated as the weight in kilograms divided by the height in meters squared) and changes in inflammation markers were assessed using random effects models. Results. Of 246 participants, 27% were overweight/obese (BMI, ≥ 25), and 8% were underweight (BMI < 18.5) at baseline. After 48 weeks, 37% were overweight/obese, and 3% were underweight. While level of many inflammatory markers decreased 48 weeks after ART initiation in the overall group, the decrease in C-reactive protein (CRP) level was smaller in overweight/obese participants (P = .01), and the decreases in both CRP (P = .01) and interleukin 18 (P = .02) levels were smaller in underweight participants. Each 1-unit gain in BMI among overweight/obese participants was associated with a 0.02-log10 increase in soluble CD14 level (P = .05), while each 1-unit BMI gain among underweight participants was associated with a 9.32-mg/L decrease in CRP level (P = .001). Conclusions. Being either overweight or underweight at ART initiation was associated with heightened systemic inflammation. While weight gain among overweight/obese persons predicted increased inflammation, weight gain among underweight persons predicted reduced inflammation.engUniversity of Chicago PressInflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleImmune activation/inflammationBody mass indexHIV/AIDSHAART clinical outcomesNoncommunicable diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15224/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMave V Inflammation and change....pdfMave V Inflammation and change....pdfapplication/pdf451120https://www.arca.fiocruz.br/bitstream/icict/15224/2/Mave%20V%20Inflammation%20and%20change....pdf836bf0342eee860b18b4bdcbf0f9b0f5MD52TEXTMave V Inflammation and change....pdf.txtMave V Inflammation and change....pdf.txtExtracted texttext/plain46185https://www.arca.fiocruz.br/bitstream/icict/15224/3/Mave%20V%20Inflammation%20and%20change....pdf.txt1352c66141bd2dd17ec9eff8ff8da61aMD53icict/152242023-03-15 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| dc.title.pt_BR.fl_str_mv |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| title |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| spellingShingle |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults Mave, Vidya Immune activation/inflammation Body mass index HIV/AIDS HAART clinical outcomes Noncommunicable diseases |
| title_short |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| title_full |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| title_fullStr |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| title_full_unstemmed |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| title_sort |
Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults |
| author |
Mave, Vidya |
| author_facet |
Mave, Vidya Erlandson, Kristine M Gupte, Nikhil Balagopal, Ashwin Asmuth, David M Campbell, Thomas B Smeaton, Laura Kumarasamy, Nagalingeswaran Hakim, James Santos, Breno Riviere, Cynthia Hosseinipour, Mina C Sugandhavesa, Patcharaphan Infante, Rosa Pillay, Sandy Cardoso, Sandra Wagner Tripathy, Srikanth Mwelase, Noluthando Berendes, Sima Andrade, Bruno de Bezerril Thomas, David L Bollinger, Robert C Gupta, Amita |
| author_role |
author |
| author2 |
Erlandson, Kristine M Gupte, Nikhil Balagopal, Ashwin Asmuth, David M Campbell, Thomas B Smeaton, Laura Kumarasamy, Nagalingeswaran Hakim, James Santos, Breno Riviere, Cynthia Hosseinipour, Mina C Sugandhavesa, Patcharaphan Infante, Rosa Pillay, Sandy Cardoso, Sandra Wagner Tripathy, Srikanth Mwelase, Noluthando Berendes, Sima Andrade, Bruno de Bezerril Thomas, David L Bollinger, Robert C Gupta, Amita |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mave, Vidya Erlandson, Kristine M Gupte, Nikhil Balagopal, Ashwin Asmuth, David M Campbell, Thomas B Smeaton, Laura Kumarasamy, Nagalingeswaran Hakim, James Santos, Breno Riviere, Cynthia Hosseinipour, Mina C Sugandhavesa, Patcharaphan Infante, Rosa Pillay, Sandy Cardoso, Sandra Wagner Tripathy, Srikanth Mwelase, Noluthando Berendes, Sima Andrade, Bruno de Bezerril Thomas, David L Bollinger, Robert C Gupta, Amita |
| dc.subject.en.pt_BR.fl_str_mv |
Immune activation/inflammation Body mass index HIV/AIDS HAART clinical outcomes Noncommunicable diseases |
| topic |
Immune activation/inflammation Body mass index HIV/AIDS HAART clinical outcomes Noncommunicable diseases |
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ACTG PEARLS and NWCS 319 Study Team |
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2016 |
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2016-08-10T14:12:08Z |
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2016-08-10T14:12:08Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MAVE, V. et al. Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults. • Journal of Infectious Diseases, v. 214, p. 65-72, 2016. |
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https://www.arca.fiocruz.br/handle/icict/15224 |
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0022-1899 |
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10.1093/infdis/jiw096 |
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MAVE, V. et al. Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults. • Journal of Infectious Diseases, v. 214, p. 65-72, 2016. 0022-1899 10.1093/infdis/jiw096 |
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University of Chicago Press |
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University of Chicago Press |
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