Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14658 |
Resumo: | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Andrade, Zilton de AraújoPeixoto, EdiriomarGuerret, SylvianeGrimaud, Jean-Alexis2016-06-28T16:45:40Z2016-07-07T11:39:45Z2016-06-28T16:45:40Z2016-07-07T11:39:45Z1992ANDRADE, Z. A. et al. Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis. Human Pathology, v. 23, n. 5, p. 566-573, 1992.0046-8177https://www.arca.fiocruz.br/handle/icict/14658engWB SaundersHepatic Connective Tissue Changes in Hepatosplenic Schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilRoberto Santos Central Hospital. Salvador, BA, BrasilInstitut Pasteur. Lyon, FranceInstitut Pasteur. Lyon, FranceDestruction of intrahepatic portal vein branches with dispersion of smooth muscle cells into the periportal fibrosis and preservation of arterial and ductal structures were the main characteristic findings seen in 66 surgical liver biopsies from patients with the hepatosplenic form of schistosomiasis. Besides these diagnostic features, the present histologic, immunocytochemical, and ultrastructural study revealed the presence of a complex matrix forming the portal and septal fibrosis in advanced schistosomiasis. There was marked hyperplasia of elastic tissue, presence of several collagen isotypes (I, III, procollagen III, IV, and V), actin. desmin, fibronectin, and laminin in a richly vascularized connective tissue. Signs of multifocal matrix (collagen) degradation were observed both at light and electron microscopic levels, suggesting a predominance of a fibrolytic process, at the time parasite-related lesions had almost disappeared. The latter findings are related to the involution of periportal fibrosis now being observed in patients who have undergone antischistosomal chemotherapy. They exemplify morphologic changes connected with chronic collagen degradation in human schistosomiasis that are similar to those first seen in experimental material. Evidence of either persistent or active chronic hepatitis was seen in several cases but its etiology could not be determined.Periportal fibrosisPipe-stem fibrosisSchistosomiasisHepatosplenir diseaseCollagen degradationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAndrade ZA Hepatic connective....pdf.txtAndrade ZA Hepatic connective....pdf.txtExtracted texttext/plain27976https://www.arca.fiocruz.br/bitstream/icict/14658/4/Andrade%20ZA%20Hepatic%20connective....pdf.txt8f44ee0f0bbedabeccdda3c11ac8809fMD54ORIGINALAndrade ZA Hepatic connective....pdfapplication/pdf7948561https://www.arca.fiocruz.br/bitstream/icict/14658/2/Andrade%20ZA%20Hepatic%20connective....pdf3b24d3ddbb617efb6ac86109b90a3a94MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14658/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146582023-03-15 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dc.title.pt_BR.fl_str_mv |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
title |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
spellingShingle |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis Andrade, Zilton de Araújo Periportal fibrosis Pipe-stem fibrosis Schistosomiasis Hepatosplenir disease Collagen degradation |
title_short |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
title_full |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
title_fullStr |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
title_full_unstemmed |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
title_sort |
Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis |
author |
Andrade, Zilton de Araújo |
author_facet |
Andrade, Zilton de Araújo Peixoto, Ediriomar Guerret, Sylviane Grimaud, Jean-Alexis |
author_role |
author |
author2 |
Peixoto, Ediriomar Guerret, Sylviane Grimaud, Jean-Alexis |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Andrade, Zilton de Araújo Peixoto, Ediriomar Guerret, Sylviane Grimaud, Jean-Alexis |
dc.subject.en.pt_BR.fl_str_mv |
Periportal fibrosis Pipe-stem fibrosis Schistosomiasis Hepatosplenir disease Collagen degradation |
topic |
Periportal fibrosis Pipe-stem fibrosis Schistosomiasis Hepatosplenir disease Collagen degradation |
description |
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
1992 |
dc.date.issued.fl_str_mv |
1992 |
dc.date.accessioned.fl_str_mv |
2016-06-28T16:45:40Z 2016-07-07T11:39:45Z |
dc.date.available.fl_str_mv |
2016-06-28T16:45:40Z 2016-07-07T11:39:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, Z. A. et al. Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis. Human Pathology, v. 23, n. 5, p. 566-573, 1992. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/14658 |
dc.identifier.issn.pt_BR.fl_str_mv |
0046-8177 |
identifier_str_mv |
ANDRADE, Z. A. et al. Hepatic Connective Tissue Changes in Hepatosplenic Schistosomiasis. Human Pathology, v. 23, n. 5, p. 566-573, 1992. 0046-8177 |
url |
https://www.arca.fiocruz.br/handle/icict/14658 |
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eng |
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eng |
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dc.publisher.none.fl_str_mv |
WB Saunders |
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WB Saunders |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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