Global morbidity and mortality of leptospirosis: a systematic review

Detalhes bibliográficos
Autor(a) principal: Costa, Federico
Data de Publicação: 2015
Outros Autores: Hagan, José E, Calcagno, Juan, Kane, Michael, Torgerson, Paul, Martinez-Silveira, Martha Silvia, Stein, Claudia, Abela-Ridder, Bernadette, Ko, Albert Icksang
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11922
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil. Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, Bahia, Brasil. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, Estados Unidos.
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spelling Costa, FedericoHagan, José ECalcagno, JuanKane, MichaelTorgerson, PaulMartinez-Silveira, Martha SilviaStein, ClaudiaAbela-Ridder, BernadetteKo, Albert Icksang2015-10-07T19:40:49Z2015-10-07T19:40:49Z2015COSTA, F. et al. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Neglected Tropical Diseases, v. 9, n. 9, p. 1-19, 2015.1935-2735https://www.arca.fiocruz.br/handle/icict/1192210.1371/journal.pntd.0003898engPublic Library of ScienceLeptospiroseMortalidadeMorbidadeEpidemiologiaLeptospirosisMorbidityMortalityEpidemiologyLeptospiroseVigilância da PopulaçãoGlobal morbidity and mortality of leptospirosis: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil. Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, Bahia, Brasil. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, Estados Unidos.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, Estados Unidos.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil.Yale School of Public Health. Center for Analytical Sciences. New Haven, Connecticut, Estados UnidosUniversity of Zürich. Vetsuisse Faculty. Section of Epidemiology. Zurich, SuiçaFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil.World Health Organization, Regional Office for Europe. Division of Information, Evidence, Research and Innovation. Copenhagen, DinamarcaWorld Health Organization. Department for the Control of Neglected Tropical Diseases. Geneve. SuizaFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, Estados Unidos.Background Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis is a life-threatening disease and recognized as an important cause of pulmonary haemorrhage syndrome, the lack of global estimates for morbidity and mortality has contributed to its neglected disease status. Methodology/Principal Findings We conducted a systematic review of published morbidity and mortality studies and databases to extract information on disease incidence and case fatality ratios. Linear regression and Monte Carlo modelling were used to obtain age and gender-adjusted estimates of disease morbidity for countries and Global Burden of Disease (GBD) and WHO regions. We estimated mortality using models that incorporated age and gender-adjusted disease morbidity and case fatality ratios. The review identified 80 studies on disease incidence from 34 countries that met quality criteria. In certain regions, such as Africa, few quality assured studies were identified. The regression model, which incorporated country-specific variables of population structure, life expectancy at birth, distance from the equator, tropical island, and urbanization, accounted for a significant proportion (R2 = 0.60) of the variation in observed disease incidence. We estimate that there were annually 1.03 million cases (95% CI 434,000–1,750,000) and 58,900 deaths (95% CI 23,800–95,900) due to leptospirosis worldwide. A large proportion of cases (48%, 95% CI 40–61%) and deaths (42%, 95% CI 34–53%) were estimated to occur in adult males with age of 20–49 years. Highest estimates of disease morbidity and mortality were observed in GBD regions of South and Southeast Asia, Oceania, Caribbean, Andean, Central, and Tropical Latin America, and East Sub-Saharan Africa. Conclusions/Significance Leptospirosis is among the leading zoonotic causes of morbidity worldwide and accounts for numbers of deaths, which approach or exceed those for other causes of haemorrhagic fever. Highest morbidity and mortality were estimated to occur in resource-poor countries, which include regions where the burden of leptospirosis has been underappreciatedinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11922/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALCosta Global morbidity and mortality.pdfCosta Global morbidity and mortality.pdfapplication/pdf1433211https://www.arca.fiocruz.br/bitstream/icict/11922/2/Costa%20Global%20morbidity%20and%20mortality.pdf7104e90ea3639736802a9d2b1ae1c9f5MD52TEXTCosta Global morbidity and mortality.pdf.txtCosta Global morbidity and mortality.pdf.txtExtracted texttext/plain63917https://www.arca.fiocruz.br/bitstream/icict/11922/3/Costa%20Global%20morbidity%20and%20mortality.pdf.txtafb23494ae605a3ed86de58e64aa424eMD53icict/119222023-03-15 14:33:10.028oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Global morbidity and mortality of leptospirosis: a systematic review
title Global morbidity and mortality of leptospirosis: a systematic review
spellingShingle Global morbidity and mortality of leptospirosis: a systematic review
Costa, Federico
Leptospirose
Mortalidade
Morbidade
Epidemiologia
Leptospirosis
Morbidity
Mortality
Epidemiology
Leptospirose
Vigilância da População
title_short Global morbidity and mortality of leptospirosis: a systematic review
title_full Global morbidity and mortality of leptospirosis: a systematic review
title_fullStr Global morbidity and mortality of leptospirosis: a systematic review
title_full_unstemmed Global morbidity and mortality of leptospirosis: a systematic review
title_sort Global morbidity and mortality of leptospirosis: a systematic review
author Costa, Federico
author_facet Costa, Federico
Hagan, José E
Calcagno, Juan
Kane, Michael
Torgerson, Paul
Martinez-Silveira, Martha Silvia
Stein, Claudia
Abela-Ridder, Bernadette
Ko, Albert Icksang
author_role author
author2 Hagan, José E
Calcagno, Juan
Kane, Michael
Torgerson, Paul
Martinez-Silveira, Martha Silvia
Stein, Claudia
Abela-Ridder, Bernadette
Ko, Albert Icksang
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Federico
Hagan, José E
Calcagno, Juan
Kane, Michael
Torgerson, Paul
Martinez-Silveira, Martha Silvia
Stein, Claudia
Abela-Ridder, Bernadette
Ko, Albert Icksang
dc.subject.other.pt_BR.fl_str_mv Leptospirose
Mortalidade
Morbidade
Epidemiologia
topic Leptospirose
Mortalidade
Morbidade
Epidemiologia
Leptospirosis
Morbidity
Mortality
Epidemiology
Leptospirose
Vigilância da População
dc.subject.en.pt_BR.fl_str_mv Leptospirosis
Morbidity
Mortality
Epidemiology
dc.subject.decs.pt_BR.fl_str_mv Leptospirose
Vigilância da População
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, Bahia, Brasil. Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, Bahia, Brasil. Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, Estados Unidos.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-10-07T19:40:49Z
dc.date.available.fl_str_mv 2015-10-07T19:40:49Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, F. et al. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Neglected Tropical Diseases, v. 9, n. 9, p. 1-19, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11922
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0003898
identifier_str_mv COSTA, F. et al. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Neglected Tropical Diseases, v. 9, n. 9, p. 1-19, 2015.
1935-2735
10.1371/journal.pntd.0003898
url https://www.arca.fiocruz.br/handle/icict/11922
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11922/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11922/2/Costa%20Global%20morbidity%20and%20mortality.pdf
https://www.arca.fiocruz.br/bitstream/icict/11922/3/Costa%20Global%20morbidity%20and%20mortality.pdf.txt
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