Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission

Detalhes bibliográficos
Autor(a) principal: Andrade, Cynthia de Paula
Data de Publicação: 2019
Outros Autores: Coelho, Paulo Ricardo Silva, Nascimento, Ricardo Aurélio Pinto, Mota, Pedro Moacyr Pinto Coelho, Silva, Marco Aurélio Romano, Alvarenga, Kevin Augusto Faria de, Schall, Virgínia Torres, Pimenta, Denise Nacif, Coelho, Paulo Marcos Zech, Oliveira, Edward José de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39662
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil.
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spelling Andrade, Cynthia de PaulaCoelho, Paulo Ricardo SilvaNascimento, Ricardo Aurélio PintoMota, Pedro Moacyr Pinto CoelhoSilva, Marco Aurélio RomanoAlvarenga, Kevin Augusto Faria deSchall, Virgínia TorresPimenta, Denise NacifCoelho, Paulo Marcos ZechOliveira, Edward José de2020-01-31T16:04:40Z2020-01-31T16:04:40Z2019ANDRADE, Cynthia de Paula et al. Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission. Revista da Sociedade Brasileira de Medicina Tropical, v. 52, p. 1-8, 2019.0037-8682https://www.arca.fiocruz.br/handle/icict/3966210.1590/0037-8682-0252-201910.1590/0037-8682-0252-2019engSociedade Brasileira de Medicina TropicalDevelopment of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil.Laboratório Nacional Agropecuário. Pedro Leopoldo, MG, Brasil.Laboratório Nacional Agropecuário. Pedro Leopoldo, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Neurociência. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Neurociência. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.INTRODUCTION: In Brazil, Biomphalaria glabrata, B. tenagophila, and B. straminea are intermediate hosts of Schistosoma mansoni, the etiological agent of schistosomiasis mansoni. Molluscicide use is recommended by the WHO for controlling the transmission of this parasite. Euphorbia milii latex has shown promising results as an alternative molluscicide. Thus, a natural molluscicide prototype kit based on freeze-dried E. milii latex was developed and evaluated against Biomphalaria spp. METHODS: E. milii latex was collected, processed, and lyophilized. Two diluents were defined for freeze-dried latex rehydration, and a prototype kit, called MoluSchall, was produced. A stability test was conducted using prototype kits stored at different temperatures, and a toxicity assay was performed using Danio rerio. Additionally, MoluSchall was tested against B. glabrata under semi-natural conditions according to defined conditions in the laboratory. RESULTS: MoluSchall was lethal to three Brazilian snail species while exhibiting low toxicity to D. rerio. Regardless of storage temperature, MoluSchall was stable for 24 months and was effective against B. glabrata under semi-natural conditions, with the same LD100 as observed under laboratory conditions. CONCLUSIONS: MoluSchall is a natural, effective, and inexpensive molluscicide with lower environmental toxicity than existing molluscicides. Its production offers a possible alternative strategy for controlling S. mansoni transmission.Euphorbia miliiMoluSchallNatural molluscicidePrototype kitSchistosomiasis controlinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/39662/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDevelopment of a natural molluscicide prototype.pdfDevelopment of a natural molluscicide prototype.pdfapplication/pdf6248206https://www.arca.fiocruz.br/bitstream/icict/39662/2/Development%20of%20a%20natural%20molluscicide%20prototype.pdf7cf37e27db4235a974423d1ff292b494MD52TEXTDevelopment of a natural molluscicide prototype.pdf.txtDevelopment of a natural molluscicide prototype.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
title Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
spellingShingle Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
Andrade, Cynthia de Paula
Euphorbia milii
MoluSchall
Natural molluscicide
Prototype kit
Schistosomiasis control
title_short Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
title_full Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
title_fullStr Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
title_full_unstemmed Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
title_sort Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission
author Andrade, Cynthia de Paula
author_facet Andrade, Cynthia de Paula
Coelho, Paulo Ricardo Silva
Nascimento, Ricardo Aurélio Pinto
Mota, Pedro Moacyr Pinto Coelho
Silva, Marco Aurélio Romano
Alvarenga, Kevin Augusto Faria de
Schall, Virgínia Torres
Pimenta, Denise Nacif
Coelho, Paulo Marcos Zech
Oliveira, Edward José de
author_role author
author2 Coelho, Paulo Ricardo Silva
Nascimento, Ricardo Aurélio Pinto
Mota, Pedro Moacyr Pinto Coelho
Silva, Marco Aurélio Romano
Alvarenga, Kevin Augusto Faria de
Schall, Virgínia Torres
Pimenta, Denise Nacif
Coelho, Paulo Marcos Zech
Oliveira, Edward José de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Cynthia de Paula
Coelho, Paulo Ricardo Silva
Nascimento, Ricardo Aurélio Pinto
Mota, Pedro Moacyr Pinto Coelho
Silva, Marco Aurélio Romano
Alvarenga, Kevin Augusto Faria de
Schall, Virgínia Torres
Pimenta, Denise Nacif
Coelho, Paulo Marcos Zech
Oliveira, Edward José de
dc.subject.en.pt_BR.fl_str_mv Euphorbia milii
MoluSchall
Natural molluscicide
Prototype kit
Schistosomiasis control
topic Euphorbia milii
MoluSchall
Natural molluscicide
Prototype kit
Schistosomiasis control
description Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Oncológicas. Belo Horizonte, MG, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-01-31T16:04:40Z
dc.date.available.fl_str_mv 2020-01-31T16:04:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Cynthia de Paula et al. Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission. Revista da Sociedade Brasileira de Medicina Tropical, v. 52, p. 1-8, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39662
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/0037-8682-0252-2019
dc.identifier.eissn.none.fl_str_mv 10.1590/0037-8682-0252-2019
identifier_str_mv ANDRADE, Cynthia de Paula et al. Development of a natural molluscicide prototype kit (MoluSchall) for the control of schistosomiasis mansoni transmission. Revista da Sociedade Brasileira de Medicina Tropical, v. 52, p. 1-8, 2019.
0037-8682
10.1590/0037-8682-0252-2019
url https://www.arca.fiocruz.br/handle/icict/39662
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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