Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29876 |
Resumo: | Laboratório Central de Saúde Pública. Setor de Virologia. Fortaleza, CE, Brasil / Universidade Estadual do Ceará. Rede Nordeste de Biotecnologia. Fortaleza, CE, Brasil. |
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Ramalho, Izabel Letícia CavalcanteAraújo, Fernanda Montenegro de CarvalhoCavalcanti, Luciano Pamplona de GóesBraga, Deborah Nunes MeloPerdigão, Anne Carolinne BezerraSantos, Flávia Barreto dosNogueira, Fernanda de BruyckerEscóssia, Kiliana Nogueira Farias daGuedes, Maria Izabel Florindo2018-11-06T10:26:38Z2018-11-06T10:26:38Z2018RAMALHO, Izabel Letícia Cavalcante; et al. Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state. Mem Inst Oswaldo Cruz, v.113, n.11, e180320, 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2987610.1590/0074-027601803201678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzDengue Virus-Tipo 4EpidemiologiaMortesGenotipagemCearáBrasildengue 4epidemiologydeathsgenotypingCearáBrazilDengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the stateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLaboratório Central de Saúde Pública. Setor de Virologia. Fortaleza, CE, Brasil / Universidade Estadual do Ceará. Rede Nordeste de Biotecnologia. Fortaleza, CE, Brasil.Laboratório Central de Saúde Pública. Setor de Virologia. Fortaleza, CE, Brasil / Centro Universitário Christus. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Departamento de Saúde Comunitária. Fortaleza, CE, Brasil.Instituto de Prevenção de Câncer. Fortaleza, CE, Brasil.Centro Universitário Christus. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Secretaria de Saúde do Estado do Ceará. Núcleo de Vigilância Epidemiológica. Fortaleza, CE, Brasil.Universidade Estadual do Ceará. Rede Nordeste de Biotecnologia. Fortaleza, CE, Brasil.BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Cearáinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29876/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfernanda_nogueira_etal_IOC_-2018.pdffernanda_nogueira_etal_IOC_-2018.pdfapplication/pdf619750https://www.arca.fiocruz.br/bitstream/icict/29876/2/fernanda_nogueira_etal_IOC_-2018.pdff099b9544021891c0f93fd45d023fcd7MD52TEXTfernanda_nogueira_etal_IOC_-2018.pdf.txtfernanda_nogueira_etal_IOC_-2018.pdf.txtExtracted texttext/plain30196https://www.arca.fiocruz.br/bitstream/icict/29876/3/fernanda_nogueira_etal_IOC_-2018.pdf.txt834b214ca2a7877f5cbb18dee92e85b2MD53icict/298762020-07-21 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| dc.title.pt_BR.fl_str_mv |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| spellingShingle |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state Ramalho, Izabel Letícia Cavalcante Dengue Virus-Tipo 4 Epidemiologia Mortes Genotipagem Ceará Brasil dengue 4 epidemiology deaths genotyping Ceará Brazil |
| title_short |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_full |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_fullStr |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_full_unstemmed |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_sort |
Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| author |
Ramalho, Izabel Letícia Cavalcante |
| author_facet |
Ramalho, Izabel Letícia Cavalcante Araújo, Fernanda Montenegro de Carvalho Cavalcanti, Luciano Pamplona de Góes Braga, Deborah Nunes Melo Perdigão, Anne Carolinne Bezerra Santos, Flávia Barreto dos Nogueira, Fernanda de Bruycker Escóssia, Kiliana Nogueira Farias da Guedes, Maria Izabel Florindo |
| author_role |
author |
| author2 |
Araújo, Fernanda Montenegro de Carvalho Cavalcanti, Luciano Pamplona de Góes Braga, Deborah Nunes Melo Perdigão, Anne Carolinne Bezerra Santos, Flávia Barreto dos Nogueira, Fernanda de Bruycker Escóssia, Kiliana Nogueira Farias da Guedes, Maria Izabel Florindo |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ramalho, Izabel Letícia Cavalcante Araújo, Fernanda Montenegro de Carvalho Cavalcanti, Luciano Pamplona de Góes Braga, Deborah Nunes Melo Perdigão, Anne Carolinne Bezerra Santos, Flávia Barreto dos Nogueira, Fernanda de Bruycker Escóssia, Kiliana Nogueira Farias da Guedes, Maria Izabel Florindo |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Virus-Tipo 4 Epidemiologia Mortes Genotipagem Ceará Brasil |
| topic |
Dengue Virus-Tipo 4 Epidemiologia Mortes Genotipagem Ceará Brasil dengue 4 epidemiology deaths genotyping Ceará Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
dengue 4 epidemiology deaths genotyping Ceará Brazil |
| description |
Laboratório Central de Saúde Pública. Setor de Virologia. Fortaleza, CE, Brasil / Universidade Estadual do Ceará. Rede Nordeste de Biotecnologia. Fortaleza, CE, Brasil. |
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2018 |
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2018-11-06T10:26:38Z |
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2018-11-06T10:26:38Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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RAMALHO, Izabel Letícia Cavalcante; et al. Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state. Mem Inst Oswaldo Cruz, v.113, n.11, e180320, 2018. |
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https://www.arca.fiocruz.br/handle/icict/29876 |
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0074-0276 |
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10.1590/0074-02760180320 |
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1678-8060 |
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RAMALHO, Izabel Letícia Cavalcante; et al. Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state. Mem Inst Oswaldo Cruz, v.113, n.11, e180320, 2018. 0074-0276 10.1590/0074-02760180320 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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