Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50793 |
Resumo: | Genomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany. |
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Lu, YeGentiluomo, ManuelMacauda, AngelicaGioffreda, DomenicaGazouli, MariaPetrone, Maria C.Kelemen, DezsöGinocchi, LauraMorelli, LucaPapiris, KonstantinosGreenhalf, WilliamIzbicki, Jakob R.Kiudelis, VytautasMohelníková -Duchoñova, BeatriceBueno-de-Mesquita, BasVodicka, PavelBrenner, HermannDiener, Markus K.Pezzilli, RaffaeleIvanauskas, AudriusSalvia, RobertoSzentesi, AndreaAoki, Mateus NóbregaNémeth, Balázs C.Sperti, CosimoJamroziak, KrzysztofChammas, RogerOliverius, MartinArchibugi, LiviaErmini, StefanoNovák, JánosKupcinskas, JuozasStrouhal, OndrejSoucek, PavelCavestro, Giulia M.Milanetto, Anna C.Vanella, GiuseppeNeoptolemos, John P.Theodoropoulos, George E.Laarhoven, Hanneke W. M. vanMambrini, AndreaMoz, StefaniaKala, ZdenekLovecek, MartinBasso, DanielaUzunoglu, Faik G.Hackert, ThiloTestoni, Sabrina G. G.Hlavác, ViktorAndriulli, AngeloLucchesi, MaurizioTavano, FrancescaCarrara, SilviaHegyi, PéterArcidiacono, Paolo G.Busch, Olivier R.Lawlor, Rita T.Puzzono, MartaBoggi, UgoGuo, FengMałecka-Panas, EwaCapurso, GabrieleLandi, StefanoTalar-Wojnarowska, RenataStrobel, OliverGao, XinVashist, YogeshCampa, DanieleCanzian, Federico2022-01-18T12:04:02Z2022-01-18T12:04:02Z2021LU, Ye et al. Identification of recessively inherited genetic variants potentially linked to pancreatic Cancer Risk. Frontiers in Immunology, v. 11, n. 771312, p. 1–11, 2021.2234-943Xhttps://www.arca.fiocruz.br/handle/icict/5079310.3389/fonc.2021.771312porFrontiers Mediacâncer de pâncreasPolymorphism, GeneticPancreatic NeoplasmsGenome-Wide Association StudyPolimorfismo GenéticoNeoplasias PancreáticasEstudio de Asociación del Genoma CompletoPolymorphisme génétiqueTumeurs du pancréasÉtude d'association pangénomiqueNeoplasias PancreáticasPolimorfismo GenéticoEstudo de Associação Genômica AmplaIdentification of recessively inherited genetic variants potentially linked to pancreatic cancer riskinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGenomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany.Department of Biology. University of Pisa. Pisa, Italy.Genomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany.Division of Gastroenterology and Research Laboratory. Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza. San Giovanni Rotondo, Italy.Department of Basic Medical Sciences. Laboratory of Biology. Medical School. National and Kapodistrian University of Athens. Athens, Greece.Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center IRSSC. San Raffaele Scientific Institute. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS). Milan, Italy.Department of Surgery. Medical School. University of Pécs, Pécs, Hungary.Oncological Department. Oncological Unit of Massa Carrara. Azienda Unità Sanitaria Locale (USL). Carrara, Italy.General Surgery. Department of Translational Research and New Technologies in Medicine and Surgery. University of Pisa. Pisa, Italy.Endoscopic Surgery Department. Hippocratio General Hospital of Athens. Athens, Greece.Department of Molecular and Clinical Cancer Medicine. University of Liverpool. Liverpool, United KingdomDepartment of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania.Department of Oncology. Faculty of Medicine and Dentistry. Palacky University Olomouc and University Hospital Olomouc. Olomouc, Czechia.Department for Determinants of Chronic Diseases (DCD). National Institute for Public Health and the Environment (RIVM). Bilthoven, Netherlands.Department of Molecular Biology of Cancer. Institute of Experimental Medicine of the Czech Academy of Sciences. Prague, Czechia. / Faculty of Medicine and Biomedical Center in Pilsen. Charles University. Pilsen, Czechia. / First Faculty of Medicine. Institute of Biology and Medical Genetics. Prague, Czechia.Division of Clinical Epidemiology and Aging Research. German Cancer Research Center (DKFZ). Heidelberg, Germany. / Division of Preventive Oncology. German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT). Heidelberg, Germany. / German Cancer Consortium (DKTK). German Cancer Research Center (DKFZ). Heidelberg, Germany.Department of General Surgery. University of Heidelberg. Heidelberg, Germany.Department of Internal Medicine. San Carlo Hospital. Potenza, Italy.Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania.Department of General and Pancreatic Surgery. The Pancreas Institute. University and Hospital Trust of Verona. Verona, Italy.Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Department of Medicine. University of Szeged. Szeged, Hungary.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.First Department of Medicine. University of Szeged. Szeged, Hungary.Department of Surgery-Dipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche (DiSCOG). Padua University Hospital. Padua, Italy.Department of Hematology. Transplantation and Internal Medicine. Medical University of Warsaw. Warsaw, Poland.Instituto do Cancêr de São Paulo. Departamento de Radiologia e Oncologia. São Paulo, Brasil. / Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Department of Surgery. Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine. Charles University. Prague, Czechia.Digestive and Liver Disease Unit. Sant’ Andrea Hospital. Rome, Italy. / Faculty of Medicine and Psychology. Sapienza University of Rome. Rome, Italy.Blood Transfusion Service. Children’s Hospital. Azienda Ospedaliero-Universitaria Meyer. Florence, Italy.Pándy Kálmán Hospital of Békés County. Gyula, Hungary.Department of Gastroenterology. Institute for Digestive Research. Medical Academy. Lithuanian University of Health Sciences. Kaunas, Lithuania.Department of Oncology. Faculty of Medicine and Dentistry. Palacky University Olomouc and University Hospital Olomouc. Olomouc, Czechia. / Institute of Molecular and Translational Medicine. Faculty of Medicine and Dentistry. Palacky University Olomouc. Olomouc, Czechia.Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia.Division of Experimental Oncology. Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute. Milan, Italy.Department of Surgery-Dipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche (DiSCOG). Padua University Hospital. Padua, Italy.Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center IRSSC. San Raffaele Scientific Institute. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS). Milan, Italy. / Digestive and Liver Disease Unit. Sant’ Andrea Hospital. Rome, Italy. / Faculty of Medicine and Psychology. Sapienza University of Rome. Rome, Italy.Department of General Surgery. University of Heidelberg. Heidelberg, Germany.First Propaedeutic University Surgery Clinic. Hippocratio General Hospital. Medical School. National and Kapodistrian University of Athens. Athens, Greece.Department of Medical Oncology. Cancer Center Amsterdam. Amsterdam University Medical Centers. University of Amsterdam. Amsterdam, Netherlands.Oncological Department. Oncological Unit of Massa Carrara. Azienda Unità Sanitaria Locale (USL). Carrara, Italy.Department of Medicine (DIMED). Padua University Hospital. Padua, Italy.Department of Surgery. University Hospital Brno Bohunice. Faculty of Medicine. Masaryk University. Brno, Czechia.Department of Surgery I. Faculty of Medicine and Dentistry. Palacky University Olomouc and University Hospital Olomouc. Olomouc, Czechia.Department of Medicine (DIMED). Padua University Hospital. Padua, Italy.Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.Department of General Surgery. University of Heidelberg. Heidelberg, Germany.Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center IRSSC. San Raffaele Scientific Institute. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS). Milan, Italy.Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia.Division of Gastroenterology and Research Laboratory. Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza. San Giovanni Rotondo, Italy.Oncological Department. Oncological Unit of Massa Carrara. Azienda Unità Sanitaria Locale (USL). Carrara, Italy.Division of Gastroenterology and Research Laboratory. Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza. San Giovanni Rotondo, Italy.Division of Gastroenterology and Digestive Endoscopy. Department of Gastroenterology. Humanitas Clinical and Research Center Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS). Milan, Italy.Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Department of Medicine. University of Szeged. Szeged, Hungary.Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center IRSSC. San Raffaele Scientific Institute. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS). Milan, Italy.Department of Surgery. Cancer Center Amsterdam. Amsterdam University Medical Centers. University of Amsterdam. Amsterdam, Netherlands.Division of Experimental Oncology. Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute. Milan, Italy.Division of General and Transplant Surgery. Pisa University Hospital. Pisa, Italy.Division of Clinical Epidemiology and Aging Research. German Cancer Research Center (DKFZ). Heidelberg, Germany.Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland.Pancreato-Biliary Endoscopy and Endosonography Division. Pancreas Translational and Clinical Research Center IRSSC. San Raffaele Scientific Institute. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS). Milan, Italy. / Digestive and Liver Disease Unit. Sant’ Andrea Hospital. Rome, Italy. / Faculty of Medicine and Psychology. Sapienza University of Rome. Rome, Italy.Department of Biology. University of Pisa. Pisa, Italy.Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland.Department of General Surgery. University of Heidelberg. Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research. German Cancer Research Center (DKFZ). Heidelberg, Germany.Centre for Surgical Oncology. Medias Klinikum Burghausen. Burghausen, Germany.Department of Biology. University of Pisa. Pisa, Italy.Genomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany.Case-Control Consortium (PanC4), including 8,769 cases and 7,055 controls of European ancestry. Six single nucleotide polymorphisms (SNPs) showed associations with pancreatic cancer risk according to a recessive model of inheritance. We replicated these variants in 3,212 cases and 3,470 controls collected from the PANcreatic Disease ReseArch (PANDoRA) consortium. The results of the meta-analyses confirmed that rs4626538 (7q32.2), rs7008921 (8p23.2) and rs147904962 (17q21.31) showed specific recessive effects (p<10−5) compared with the additive effects (p>10−3), although none of the six SNPs reached the conventional threshold for genome-wide significance (p < 5×10−8). Additional bioinformatic analysis explored the functional annotations of the SNPs and indicated a possible relationship between rs36018702 and expression of the BCL2L11 and BUB1 genes, which are known to be involved in pancreatic biology. Our findings, while not conclusive, indicate the importance of considering non-additive genetic models when performing GWAS analysis. The SNPs associated with pancreatic cancer in this study could be used for further meta-analysis for recessive association of SNPs and pancreatic cancer risk and might be a useful addiction to improve the performance of polygenic risk scores.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/50793/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfonc-11-771312Ok.pdffonc-11-771312Ok.pdfapplication/pdf896466https://www.arca.fiocruz.br/bitstream/icict/50793/2/fonc-11-771312Ok.pdf299780e0ba78a905b5daa8fcee5f2a90MD52icict/507932022-01-18 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| dc.title.pt_BR.fl_str_mv |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| title |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| spellingShingle |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk Lu, Ye câncer de pâncreas Polymorphism, Genetic Pancreatic Neoplasms Genome-Wide Association Study Polimorfismo Genético Neoplasias Pancreáticas Estudio de Asociación del Genoma Completo Polymorphisme génétique Tumeurs du pancréas Étude d'association pangénomique Neoplasias Pancreáticas Polimorfismo Genético Estudo de Associação Genômica Ampla |
| title_short |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| title_full |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| title_fullStr |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| title_full_unstemmed |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| title_sort |
Identification of recessively inherited genetic variants potentially linked to pancreatic cancer risk |
| author |
Lu, Ye |
| author_facet |
Lu, Ye Gentiluomo, Manuel Macauda, Angelica Gioffreda, Domenica Gazouli, Maria Petrone, Maria C. Kelemen, Dezsö Ginocchi, Laura Morelli, Luca Papiris, Konstantinos Greenhalf, William Izbicki, Jakob R. Kiudelis, Vytautas Mohelníková -Duchoñova, Beatrice Bueno-de-Mesquita, Bas Vodicka, Pavel Brenner, Hermann Diener, Markus K. Pezzilli, Raffaele Ivanauskas, Audrius Salvia, Roberto Szentesi, Andrea Aoki, Mateus Nóbrega Németh, Balázs C. Sperti, Cosimo Jamroziak, Krzysztof Chammas, Roger Oliverius, Martin Archibugi, Livia Ermini, Stefano Novák, János Kupcinskas, Juozas Strouhal, Ondrej Soucek, Pavel Cavestro, Giulia M. Milanetto, Anna C. Vanella, Giuseppe Neoptolemos, John P. Theodoropoulos, George E. Laarhoven, Hanneke W. M. van Mambrini, Andrea Moz, Stefania Kala, Zdenek Lovecek, Martin Basso, Daniela Uzunoglu, Faik G. Hackert, Thilo Testoni, Sabrina G. G. Hlavác, Viktor Andriulli, Angelo Lucchesi, Maurizio Tavano, Francesca Carrara, Silvia Hegyi, Péter Arcidiacono, Paolo G. Busch, Olivier R. Lawlor, Rita T. Puzzono, Marta Boggi, Ugo Guo, Feng Małecka-Panas, Ewa Capurso, Gabriele Landi, Stefano Talar-Wojnarowska, Renata Strobel, Oliver Gao, Xin Vashist, Yogesh Campa, Daniele Canzian, Federico |
| author_role |
author |
| author2 |
Gentiluomo, Manuel Macauda, Angelica Gioffreda, Domenica Gazouli, Maria Petrone, Maria C. Kelemen, Dezsö Ginocchi, Laura Morelli, Luca Papiris, Konstantinos Greenhalf, William Izbicki, Jakob R. Kiudelis, Vytautas Mohelníková -Duchoñova, Beatrice Bueno-de-Mesquita, Bas Vodicka, Pavel Brenner, Hermann Diener, Markus K. Pezzilli, Raffaele Ivanauskas, Audrius Salvia, Roberto Szentesi, Andrea Aoki, Mateus Nóbrega Németh, Balázs C. Sperti, Cosimo Jamroziak, Krzysztof Chammas, Roger Oliverius, Martin Archibugi, Livia Ermini, Stefano Novák, János Kupcinskas, Juozas Strouhal, Ondrej Soucek, Pavel Cavestro, Giulia M. Milanetto, Anna C. Vanella, Giuseppe Neoptolemos, John P. Theodoropoulos, George E. Laarhoven, Hanneke W. M. van Mambrini, Andrea Moz, Stefania Kala, Zdenek Lovecek, Martin Basso, Daniela Uzunoglu, Faik G. Hackert, Thilo Testoni, Sabrina G. G. Hlavác, Viktor Andriulli, Angelo Lucchesi, Maurizio Tavano, Francesca Carrara, Silvia Hegyi, Péter Arcidiacono, Paolo G. Busch, Olivier R. Lawlor, Rita T. Puzzono, Marta Boggi, Ugo Guo, Feng Małecka-Panas, Ewa Capurso, Gabriele Landi, Stefano Talar-Wojnarowska, Renata Strobel, Oliver Gao, Xin Vashist, Yogesh Campa, Daniele Canzian, Federico |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lu, Ye Gentiluomo, Manuel Macauda, Angelica Gioffreda, Domenica Gazouli, Maria Petrone, Maria C. Kelemen, Dezsö Ginocchi, Laura Morelli, Luca Papiris, Konstantinos Greenhalf, William Izbicki, Jakob R. Kiudelis, Vytautas Mohelníková -Duchoñova, Beatrice Bueno-de-Mesquita, Bas Vodicka, Pavel Brenner, Hermann Diener, Markus K. Pezzilli, Raffaele Ivanauskas, Audrius Salvia, Roberto Szentesi, Andrea Aoki, Mateus Nóbrega Németh, Balázs C. Sperti, Cosimo Jamroziak, Krzysztof Chammas, Roger Oliverius, Martin Archibugi, Livia Ermini, Stefano Novák, János Kupcinskas, Juozas Strouhal, Ondrej Soucek, Pavel Cavestro, Giulia M. Milanetto, Anna C. Vanella, Giuseppe Neoptolemos, John P. Theodoropoulos, George E. Laarhoven, Hanneke W. M. van Mambrini, Andrea Moz, Stefania Kala, Zdenek Lovecek, Martin Basso, Daniela Uzunoglu, Faik G. Hackert, Thilo Testoni, Sabrina G. G. Hlavác, Viktor Andriulli, Angelo Lucchesi, Maurizio Tavano, Francesca Carrara, Silvia Hegyi, Péter Arcidiacono, Paolo G. Busch, Olivier R. Lawlor, Rita T. Puzzono, Marta Boggi, Ugo Guo, Feng Małecka-Panas, Ewa Capurso, Gabriele Landi, Stefano Talar-Wojnarowska, Renata Strobel, Oliver Gao, Xin Vashist, Yogesh Campa, Daniele Canzian, Federico |
| dc.subject.other.pt_BR.fl_str_mv |
câncer de pâncreas |
| topic |
câncer de pâncreas Polymorphism, Genetic Pancreatic Neoplasms Genome-Wide Association Study Polimorfismo Genético Neoplasias Pancreáticas Estudio de Asociación del Genoma Completo Polymorphisme génétique Tumeurs du pancréas Étude d'association pangénomique Neoplasias Pancreáticas Polimorfismo Genético Estudo de Associação Genômica Ampla |
| dc.subject.en.pt_BR.fl_str_mv |
Polymorphism, Genetic Pancreatic Neoplasms Genome-Wide Association Study |
| dc.subject.es.pt_BR.fl_str_mv |
Polimorfismo Genético Neoplasias Pancreáticas Estudio de Asociación del Genoma Completo |
| dc.subject.fr.pt_BR.fl_str_mv |
Polymorphisme génétique Tumeurs du pancréas Étude d'association pangénomique |
| dc.subject.decs.pt_BR.fl_str_mv |
Neoplasias Pancreáticas Polimorfismo Genético Estudo de Associação Genômica Ampla |
| description |
Genomic Epidemiology Group. German Cancer Research Center (DKFZ). Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany. |
| publishDate |
2021 |
| dc.date.issued.fl_str_mv |
2021 |
| dc.date.accessioned.fl_str_mv |
2022-01-18T12:04:02Z |
| dc.date.available.fl_str_mv |
2022-01-18T12:04:02Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
LU, Ye et al. Identification of recessively inherited genetic variants potentially linked to pancreatic Cancer Risk. Frontiers in Immunology, v. 11, n. 771312, p. 1–11, 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50793 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2234-943X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fonc.2021.771312 |
| identifier_str_mv |
LU, Ye et al. Identification of recessively inherited genetic variants potentially linked to pancreatic Cancer Risk. Frontiers in Immunology, v. 11, n. 771312, p. 1–11, 2021. 2234-943X 10.3389/fonc.2021.771312 |
| url |
https://www.arca.fiocruz.br/handle/icict/50793 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/50793/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/50793/2/fonc-11-771312Ok.pdf |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
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1813009012509114368 |