The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection

Detalhes bibliográficos
Autor(a) principal: Clain, Elodie
Data de Publicação: 2019
Outros Autores: Haddad, Juliano G., Koishi, Andrea Cristine, Sinigaglia, Laura, Rachidi, Walid, Desprès, Philippe, Santos, Claudia Nunes Duarte dos, Guiraud, Pascale, Jouvenet, Nolwenn, El Kalamouni, Chaker
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33563
Resumo: Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
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spelling Clain, ElodieHaddad, Juliano G.Koishi, Andrea CristineSinigaglia, LauraRachidi, WalidDesprès, PhilippeSantos, Claudia Nunes Duarte dosGuiraud, PascaleJouvenet, NolwennEl Kalamouni, Chaker2019-06-18T17:36:49Z2019-06-18T17:36:49Z2019CLAIN, Elodie et al. The Polyphenol-Rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection. International Journal of Molecular Sciences, v. 20, n. 1860, p. 1-16, 2019.1661-6596https://www.arca.fiocruz.br/handle/icict/3356310.3390/ijms20081860porMDPICompostos naturaisPsiloxylon mauritianumZika VirusDengue VirusAntiviral AgentsPlantsDietary SupplementsVirus ZikaVirus DengueAntiviralesPlantas MedicinalesSuplementos DietéticosZika virusDengue virusAntiviraisPlantas MedicinaisSuplementos NutricionaisThe Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversité de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. CYROI. La Réunion, France.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Institut Pasteur. Viral Genomics and Vaccination Unit. Paris, France. / Université Paris Diderot. Sorbonne Paris Cité. Paris, France.Université Grenoble Alpes. INAC/CEA. Grenoble, France.Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Institut Pasteur. Viral Genomics and Vaccination Unit. Paris, France.Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/33563/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALijms-20-0186.pdfijms-20-0186.pdfapplication/pdf1857630https://www.arca.fiocruz.br/bitstream/icict/33563/2/ijms-20-0186.pdf5f9c3246400fcb45f39ce0216d0ee0a4MD52ijms-20-01860-s001.pdfijms-20-01860-s001.pdfMaterial Suplementarapplication/pdf365095https://www.arca.fiocruz.br/bitstream/icict/33563/4/ijms-20-01860-s001.pdfe131abb752a493d5c5b8361aad29865eMD54TEXTijms-20-0186.pdf.txtijms-20-0186.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
title The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
spellingShingle The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
Clain, Elodie
Compostos naturais
Psiloxylon mauritianum
Zika Virus
Dengue Virus
Antiviral Agents
Plants
Dietary Supplements
Virus Zika
Virus Dengue
Antivirales
Plantas Medicinales
Suplementos Dietéticos
Zika virus
Dengue virus
Antivirais
Plantas Medicinais
Suplementos Nutricionais
title_short The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
title_full The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
title_fullStr The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
title_full_unstemmed The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
title_sort The Polyphenol-rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection
author Clain, Elodie
author_facet Clain, Elodie
Haddad, Juliano G.
Koishi, Andrea Cristine
Sinigaglia, Laura
Rachidi, Walid
Desprès, Philippe
Santos, Claudia Nunes Duarte dos
Guiraud, Pascale
Jouvenet, Nolwenn
El Kalamouni, Chaker
author_role author
author2 Haddad, Juliano G.
Koishi, Andrea Cristine
Sinigaglia, Laura
Rachidi, Walid
Desprès, Philippe
Santos, Claudia Nunes Duarte dos
Guiraud, Pascale
Jouvenet, Nolwenn
El Kalamouni, Chaker
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Clain, Elodie
Haddad, Juliano G.
Koishi, Andrea Cristine
Sinigaglia, Laura
Rachidi, Walid
Desprès, Philippe
Santos, Claudia Nunes Duarte dos
Guiraud, Pascale
Jouvenet, Nolwenn
El Kalamouni, Chaker
dc.subject.other.pt_BR.fl_str_mv Compostos naturais
Psiloxylon mauritianum
topic Compostos naturais
Psiloxylon mauritianum
Zika Virus
Dengue Virus
Antiviral Agents
Plants
Dietary Supplements
Virus Zika
Virus Dengue
Antivirales
Plantas Medicinales
Suplementos Dietéticos
Zika virus
Dengue virus
Antivirais
Plantas Medicinais
Suplementos Nutricionais
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Dengue Virus
Antiviral Agents
Plants
Dietary Supplements
dc.subject.es.pt_BR.fl_str_mv Virus Zika
Virus Dengue
Antivirales
Plantas Medicinales
Suplementos Dietéticos
dc.subject.decs.pt_BR.fl_str_mv Zika virus
Dengue virus
Antivirais
Plantas Medicinais
Suplementos Nutricionais
description Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-06-18T17:36:49Z
dc.date.available.fl_str_mv 2019-06-18T17:36:49Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CLAIN, Elodie et al. The Polyphenol-Rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection. International Journal of Molecular Sciences, v. 20, n. 1860, p. 1-16, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33563
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms20081860
identifier_str_mv CLAIN, Elodie et al. The Polyphenol-Rich extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the early stages of Dengue and Zika Virus infection. International Journal of Molecular Sciences, v. 20, n. 1860, p. 1-16, 2019.
1661-6596
10.3390/ijms20081860
url https://www.arca.fiocruz.br/handle/icict/33563
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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