Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila

Detalhes bibliográficos
Autor(a) principal: Ishemgulova, Aygul
Data de Publicação: 2017
Outros Autores: Butenko, Anzhelika, Kortišová, Lucie, Boucinha, Carolina, Grybchuk-Ieremenko, Anastasiia, Morelli, Karina A., Tesařová, Martina, Kraeva, Natalya, Grybchuk, Danyil, Pánek, Tomáš, Flegontov, Pavel, Lukeš, Julius, Votýpka, Jan, Pavan, Márcio Galvão, Opperdoes, Fred R., Spodareva, Viktoria, Levy, Claudia M. d'Avila, Kostygov, Alexei Yu, Yurchenko, Vyacheslav
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23201
Resumo: University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic.
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spelling Ishemgulova, AygulButenko, AnzhelikaKortišová, LucieBoucinha, CarolinaGrybchuk-Ieremenko, AnastasiiaMorelli, Karina A.Tesařová, MartinaKraeva, NatalyaGrybchuk, DanyilPánek, TomášFlegontov, PavelLukeš, JuliusVotýpka, JanPavan, Márcio GalvãoOpperdoes, Fred R.Spodareva, ViktoriaLevy, Claudia M. d'AvilaKostygov, Alexei YuYurchenko, Vyacheslav2017-11-16T12:19:26Z2017-11-16T12:19:26Z2017ISHEMGULOVA, Aygul et al. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. Plos One, v.12, n.3, e0174165, Mar. 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2320110.1371/journal.pone.0174165engPublic Library of ScienceCrithidiaMecanismos molecularesresistência térmicaCrithidia luciliae thermophilaMolecular mechanismsthermal resistanceMolecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophilainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Coleção de Protozoários. Rio de Janeiro, RJ. Brasil.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Coleção de Protozoários. Rio de Janeiro, RJ. Brasil / Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcãntara Gomes. Departamento de Ecologia. Rio de Janeiro, RJ, Brasil.Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic / Russian Academy of Sciences. Institute for Information Transmission Problems. Moscow, Russia.Czech Academy of Sciences. Biology Centre. Institute of Parasitology. České Budějovice (Budweis), Czech Republic. / University of South Bohemia. Faculty of Sciences. České Budějovice (Budweis), Czech Republic / Canadian Institute for Advanced Research.Toronto, Ontario, Canada.Czech Academy of Sciences. Biology Centre. Institute of Parasitology. České Budějovice (Budweis), Czech Republic. / Charles University / Faculty of Science. Department of Parasitology. Prague, Czech Republic.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Université Catholique de Louvain. de Duve Institute. Brussels, Belgium.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Zoological Institute of the Russian Academy of Sciences. St. Petersburg, Russia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Estudos Integrados em Protozoologia. Coleção de Protozoários. Rio de Janeiro, RJ. Brasil..University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Zoological Institute of the Russian Academy of Sciences. St. Petersburg, Russia.University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic / Albert Einstein College of Medicine. Department of Pathology. New York, NY, USA / University of Ostrava. Faculty of Science. Institute of Environmental Technologies. Ostrava. Czech Republic.In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23°C) and elevated (34°C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated. Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern. This disparity illustrates differences in the biology of these two parasites and distinct mechanisms of their thermotolerance, a prerequisite for living in warm-blooded vertebrates.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23201/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALkarina_morelli_etal_IOC_2017.pdfkarina_morelli_etal_IOC_2017.pdfapplication/pdf2625831https://www.arca.fiocruz.br/bitstream/icict/23201/2/karina_morelli_etal_IOC_2017.pdfb3841b5799a272a75f5b12f45d90c281MD52TEXTkarina_morelli_etal_IOC_2017.pdf.txtkarina_morelli_etal_IOC_2017.pdf.txtExtracted texttext/plain51307https://www.arca.fiocruz.br/bitstream/icict/23201/3/karina_morelli_etal_IOC_2017.pdf.txtd0ab26d4a324c14205f6d20acf7d6b58MD53icict/232012018-08-15 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dc.title.pt_BR.fl_str_mv Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
title Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
spellingShingle Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
Ishemgulova, Aygul
Crithidia
Mecanismos moleculares
resistência térmica
Crithidia luciliae thermophila
Molecular mechanisms
thermal resistance
title_short Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
title_full Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
title_fullStr Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
title_full_unstemmed Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
title_sort Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
author Ishemgulova, Aygul
author_facet Ishemgulova, Aygul
Butenko, Anzhelika
Kortišová, Lucie
Boucinha, Carolina
Grybchuk-Ieremenko, Anastasiia
Morelli, Karina A.
Tesařová, Martina
Kraeva, Natalya
Grybchuk, Danyil
Pánek, Tomáš
Flegontov, Pavel
Lukeš, Julius
Votýpka, Jan
Pavan, Márcio Galvão
Opperdoes, Fred R.
Spodareva, Viktoria
Levy, Claudia M. d'Avila
Kostygov, Alexei Yu
Yurchenko, Vyacheslav
author_role author
author2 Butenko, Anzhelika
Kortišová, Lucie
Boucinha, Carolina
Grybchuk-Ieremenko, Anastasiia
Morelli, Karina A.
Tesařová, Martina
Kraeva, Natalya
Grybchuk, Danyil
Pánek, Tomáš
Flegontov, Pavel
Lukeš, Julius
Votýpka, Jan
Pavan, Márcio Galvão
Opperdoes, Fred R.
Spodareva, Viktoria
Levy, Claudia M. d'Avila
Kostygov, Alexei Yu
Yurchenko, Vyacheslav
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ishemgulova, Aygul
Butenko, Anzhelika
Kortišová, Lucie
Boucinha, Carolina
Grybchuk-Ieremenko, Anastasiia
Morelli, Karina A.
Tesařová, Martina
Kraeva, Natalya
Grybchuk, Danyil
Pánek, Tomáš
Flegontov, Pavel
Lukeš, Julius
Votýpka, Jan
Pavan, Márcio Galvão
Opperdoes, Fred R.
Spodareva, Viktoria
Levy, Claudia M. d'Avila
Kostygov, Alexei Yu
Yurchenko, Vyacheslav
dc.subject.other.pt_BR.fl_str_mv Crithidia
Mecanismos moleculares
resistência térmica
topic Crithidia
Mecanismos moleculares
resistência térmica
Crithidia luciliae thermophila
Molecular mechanisms
thermal resistance
dc.subject.en.pt_BR.fl_str_mv Crithidia luciliae thermophila
Molecular mechanisms
thermal resistance
description University of Ostrava. Faculty of Science. Life Science Research Centre. Ostrava, Czech Republic / Czech Academy of Sciences. Biology Centre. Institute of Parasitology. Česke Budějovice (Budweis), Czech Republic.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-11-16T12:19:26Z
dc.date.available.fl_str_mv 2017-11-16T12:19:26Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ISHEMGULOVA, Aygul et al. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. Plos One, v.12, n.3, e0174165, Mar. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23201
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0174165
identifier_str_mv ISHEMGULOVA, Aygul et al. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. Plos One, v.12, n.3, e0174165, Mar. 2017.
1932-6203
10.1371/journal.pone.0174165
url https://www.arca.fiocruz.br/handle/icict/23201
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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