A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59186 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos / Bio-Manguinhos, Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME) Rio de janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil. |
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Almeida, Daniela P. Mendes deKehdy, Fernanda S. G.Gonçalves, Remy MartinsBokel, JoannaGrinsztejn, EduardaOliveira, Patrícia Mouta Nunes deMaia, Maria de Lourdes de SousaHoagland, BrendaCardoso, Sandra WagnerGrinsztejn, BeatrizSiqueira, Marilda M.Kurtz, PedroBozza, Patricia T.Garcia, Cristiana C,2023-06-26T19:36:42Z2023-06-26T19:36:42Z2023ALMEIDA, Daniela P. Mendes de et al. A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis. ront. Cardiovasc. Med. vol .10, p. 1-14, May 2023.2297-055Xhttps://www.arca.fiocruz.br/handle/icict/5918610.3389/fcvm.2023.1189320engFrontiers MediaTrombocitopenia trombótica induzida por vacinaChAdOx1vacina nCoV-19Predisposição genéticaPolimorfismosAnticorpos anti-PF4VITTVaccine-induced thrombotic thrombocytopeniaChAdOx1nCoV-19 vaccineGenetic predispositionPolymorphismsAnti-PF4 antibodiesVITTA case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos / Bio-Manguinhos, Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME) Rio de janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Imunofarmacologia. . Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Clínica São Vicente. Unidade de Ocon-Hematologia. Rio de Janeiro, RJ, Brasil.Department of Medicine, Hematology and Oncology Division, University Hospitals, Case Western University, Cleveland, OH, United States.Bio-Manguinhos, Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME) Rio de janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil.Bio-Manguinhos, Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME) Rio de janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em STD / AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em STD / AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em STD / AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. ,Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil.Instituto D’Or de Pesquisa e Ensino, Departamento de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Imunofarmacologia. . Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. ,Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.The emergence of the rare syndrome called vaccine-induced immune thrombocytopenia and thrombosis (VITT) after adenoviral vector vaccines, including ChAdOx1 nCov-19, raises concern about one’s predisposing risk factors. Here we report the case of a 56-year-old white man who developed VITT leading to death within 9 days of symptom onset. He presented with superior sagittal sinus thrombosis, right frontal intraparenchymal hematoma, frontoparietal subarachnoid and massive ventricular hemorrhage, and right lower extremity arterial and venous thrombosis. His laboratory results showed elevated D-dimer, C-reactive protein, tissue factor, P-selectin (CD62p), and positive anti-platelet factor 4. The patient’s plasma promoted higher CD62p expression in healthy donors’ platelets than the controls. Genetic investigation on coagulation, thrombophilia, inflammation, and type I interferon-related genes was performed. From rare variants in European or African genomic databases, 68 single-nucleotide polymorphisms (SNPs) in one allele and 11 in two alleles from common SNPs were found in the patient genome. This report highlights the possible relationship between VITT and genetic variants. Additional investigations regarding the genetic predisposition of VITT are needed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59186/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandaKehdy_MarildaSiqueira_PatriciaBozza_etal_IOC_2023.pdfFernandaKehdy_MarildaSiqueira_PatriciaBozza_etal_IOC_2023.pdfapplication/pdf790511https://www.arca.fiocruz.br/bitstream/icict/59186/2/FernandaKehdy_MarildaSiqueira_PatriciaBozza_etal_IOC_2023.pdf15cd428917e6ad3483d87ed9b91c7ce6MD52icict/591862023-09-04 10:37:06.826oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T13:37:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| title |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| spellingShingle |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis Almeida, Daniela P. Mendes de Trombocitopenia trombótica induzida por vacina ChAdOx1 vacina nCoV-19 Predisposição genética Polimorfismos Anticorpos anti-PF4 VITT Vaccine-induced thrombotic thrombocytopenia ChAdOx1 nCoV-19 vaccine Genetic predisposition Polymorphisms Anti-PF4 antibodies VITT |
| title_short |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| title_full |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| title_fullStr |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| title_full_unstemmed |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| title_sort |
A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis |
| author |
Almeida, Daniela P. Mendes de |
| author_facet |
Almeida, Daniela P. Mendes de Kehdy, Fernanda S. G. Gonçalves, Remy Martins Bokel, Joanna Grinsztejn, Eduarda Oliveira, Patrícia Mouta Nunes de Maia, Maria de Lourdes de Sousa Hoagland, Brenda Cardoso, Sandra Wagner Grinsztejn, Beatriz Siqueira, Marilda M. Kurtz, Pedro Bozza, Patricia T. Garcia, Cristiana C, |
| author_role |
author |
| author2 |
Kehdy, Fernanda S. G. Gonçalves, Remy Martins Bokel, Joanna Grinsztejn, Eduarda Oliveira, Patrícia Mouta Nunes de Maia, Maria de Lourdes de Sousa Hoagland, Brenda Cardoso, Sandra Wagner Grinsztejn, Beatriz Siqueira, Marilda M. Kurtz, Pedro Bozza, Patricia T. Garcia, Cristiana C, |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Daniela P. Mendes de Kehdy, Fernanda S. G. Gonçalves, Remy Martins Bokel, Joanna Grinsztejn, Eduarda Oliveira, Patrícia Mouta Nunes de Maia, Maria de Lourdes de Sousa Hoagland, Brenda Cardoso, Sandra Wagner Grinsztejn, Beatriz Siqueira, Marilda M. Kurtz, Pedro Bozza, Patricia T. Garcia, Cristiana C, |
| dc.subject.other.en_US.fl_str_mv |
Trombocitopenia trombótica induzida por vacina ChAdOx1 vacina nCoV-19 Predisposição genética Polimorfismos Anticorpos anti-PF4 VITT |
| topic |
Trombocitopenia trombótica induzida por vacina ChAdOx1 vacina nCoV-19 Predisposição genética Polimorfismos Anticorpos anti-PF4 VITT Vaccine-induced thrombotic thrombocytopenia ChAdOx1 nCoV-19 vaccine Genetic predisposition Polymorphisms Anti-PF4 antibodies VITT |
| dc.subject.en.en_US.fl_str_mv |
Vaccine-induced thrombotic thrombocytopenia ChAdOx1 nCoV-19 vaccine Genetic predisposition Polymorphisms Anti-PF4 antibodies VITT |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos / Bio-Manguinhos, Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME) Rio de janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil. |
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2023 |
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2023-06-26T19:36:42Z |
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2023-06-26T19:36:42Z |
| dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ALMEIDA, Daniela P. Mendes de et al. A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis. ront. Cardiovasc. Med. vol .10, p. 1-14, May 2023. |
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https://www.arca.fiocruz.br/handle/icict/59186 |
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2297-055X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fcvm.2023.1189320 |
| identifier_str_mv |
ALMEIDA, Daniela P. Mendes de et al. A case report of vaccine-induced immune thrombotic thrombocytopenia (VITT) with genetic analysis. ront. Cardiovasc. Med. vol .10, p. 1-14, May 2023. 2297-055X 10.3389/fcvm.2023.1189320 |
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Frontiers Media |
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Frontiers Media |
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