Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites

Detalhes bibliográficos
Autor(a) principal: Souza, Maria Carolina Scheffer de
Data de Publicação: 2021
Outros Autores: Moura, Valéria Mourão de, Mourão, Rosa Helena Veras, Fachin-Espinar, Maria Teresa, Nunez, Cecilia Veronica, Sampaio, Maria Cristina dos Santos Sobreira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.32712/2446-4775.2021.1084
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50047
Resumo: Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Biotecnologia. Manaus, AM, Brasil.
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spelling Souza, Maria Carolina Scheffer deMoura, Valéria Mourão deMourão, Rosa Helena VerasFachin-Espinar, Maria TeresaNunez, Cecilia VeronicaSampaio, Maria Cristina dos Santos Sobreira de2021-11-24T18:24:12Z2021-11-24T18:24:12Z2021SOUZA, Maria Carolina Scheffer de et al. Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites. Revista Fitos, v. 15, n. 3, p. 280-297, Sept. 2021.1808-9569https://www.arca.fiocruz.br/handle/icict/5004710.32712/2446-4775.2021.10842446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdeAntimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Biotecnologia. Manaus, AM, Brasil.Universidade Federal do Oeste do Pará. Laboratório de Bioprospecção e Biologia Experimental. Santarém, PA, Brasil.Universidade Federal do Oeste do Pará. Laboratório de Bioprospecção e Biologia Experimental. Santarém, PA, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Bioprospecção e Biotecnologia. Departamento de Tecnologia e Inovação. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Bioprospecção e Biotecnologia. Departamento de Tecnologia e Inovação. Manaus, AM, Brasil.Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Imunoquímica. Manaus, AM, Brasil.Riverine communities in the Brazilian Amazon region use a variety of plants to treat snakebites. These plants can be effective against secondary infections, one of the main complications of snakebites. The aim of this study was to determine whether plants traditionally used to treat snakebites in the Brazilian Amazon may also have antimicrobial and antioxidant activities, and if so, which classes of chemicals may be responsible for these activities. Aqueous extracts of nine plants were tested in microdilution assays and the more active were prepared using solvents (hexane, methanol and water) and decoction, and nine assays were performed. Assays to determine the antioxidant activity of the most active species were carried out, as well as phytochemistry studies to determine the active components of this species. Bellucia dichotoma exhibited the greatest antimicrobial potential, particularly the hexane, methanol and decoction extracts. In comparative TLC, extracts of this species showed characteristics of terpenoids, compounds with double bonds and flavonoids. In ¹H NMR, characteristic signals of sterols such as β-sitosterol, stigmasterols or triterpenes were observed, as well as signals indicating the presence of aromatic hydrogens, characteristic of aromatic substances, and sugars. The methanol extracts and decoction were considered active in the antioxidant assay.Bellucia dichotomaBothrops atroxSnakebitesInfectionsAntimicrobialWound healinginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/50047/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALm_c_s_et_all.pdfArtigo em Inglêsapplication/pdf1041842https://www.arca.fiocruz.br/bitstream/icict/50047/2/m_c_s_et_all.pdf4ea27d4e0da37a49a6e5ea3f5ad5d6f9MD521084-Multimedia-7835-1-17-20210917.mp31084-Multimedia-7835-1-17-20210917.mp3Áudio em Inglês - Título, autoria, resumoaudio/basic685244https://www.arca.fiocruz.br/bitstream/icict/50047/3/1084-Multimedia-7835-1-17-20210917.mp33fb072ead3544ae8858bd588a932d124MD53icict/500472022-12-08 16:04:33.108oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-08T19:04:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
title Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
spellingShingle Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
Souza, Maria Carolina Scheffer de
Bellucia dichotoma
Bothrops atrox
Snakebites
Infections
Antimicrobial
Wound healing
title_short Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
title_full Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
title_fullStr Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
title_full_unstemmed Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
title_sort Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites
author Souza, Maria Carolina Scheffer de
author_facet Souza, Maria Carolina Scheffer de
Moura, Valéria Mourão de
Mourão, Rosa Helena Veras
Fachin-Espinar, Maria Teresa
Nunez, Cecilia Veronica
Sampaio, Maria Cristina dos Santos Sobreira de
author_role author
author2 Moura, Valéria Mourão de
Mourão, Rosa Helena Veras
Fachin-Espinar, Maria Teresa
Nunez, Cecilia Veronica
Sampaio, Maria Cristina dos Santos Sobreira de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Maria Carolina Scheffer de
Moura, Valéria Mourão de
Mourão, Rosa Helena Veras
Fachin-Espinar, Maria Teresa
Nunez, Cecilia Veronica
Sampaio, Maria Cristina dos Santos Sobreira de
dc.subject.en.en_US.fl_str_mv Bellucia dichotoma
Bothrops atrox
Snakebites
Infections
Antimicrobial
Wound healing
topic Bellucia dichotoma
Bothrops atrox
Snakebites
Infections
Antimicrobial
Wound healing
description Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Biotecnologia. Manaus, AM, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-24T18:24:12Z
dc.date.available.fl_str_mv 2021-11-24T18:24:12Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Maria Carolina Scheffer de et al. Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites. Revista Fitos, v. 15, n. 3, p. 280-297, Sept. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50047
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2021.1084
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv SOUZA, Maria Carolina Scheffer de et al. Antimicrobial activity of Amazonian plant species against the causative agents of secondary infection in snakebites. Revista Fitos, v. 15, n. 3, p. 280-297, Sept. 2021.
1808-9569
10.32712/2446-4775.2021.1084
2446-4775
url https://www.arca.fiocruz.br/handle/icict/50047
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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