Parametric analysis of a biokinetic model: a contribution to the study of model reliability

Detalhes bibliográficos
Autor(a) principal: Lourenço, M. C.
Data de Publicação: 1998
Outros Autores: Lipsztein, J. L., Szwarcwald, Celia Landmann
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/659
Resumo: I M. C. Lourenc, II J. L. Lipsztein and III C. L. Szwarcwald/ 1 Instituto de Radioproteção e Dosimetria Av. Salvador Allende, s/n, CEP 22780–160, Rio de Janeiro – RJ, Brazil / 2 Instituto de Biologia, Universidade do Estado do Rio de Janeiro Av. 28 de Setembro, 87, CEP 20551–030, Rio de Janeiro – RJ, Brazil/ 3 Departamento de Saúde, Fundação Oswaldo Cruz Av. Brasil, 4365, CEP 21045–900, Rio de Janeiro – RJ, Brazil
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spelling Lourenço, M. C.Lipsztein, J. L.Szwarcwald, Celia Landmann2010-08-23T16:58:36Z2010-11-04T14:20:03Z2010-11-04T14:20:03Z2010-08-23T16:58:36Z1998LOURENÇO, M. C.; LIPSZTEIN, J. L.; SZWARCWALD, C. L. Parametric analysis of a biokinetic model: a contribution to the study of model reliability. Radiation Protection Dosimetry, v. 79, p. 205-209, 1998.1742-3406https://www.arca.fiocruz.br/handle/icict/659I M. C. Lourenc, II J. L. Lipsztein and III C. L. Szwarcwald/ 1 Instituto de Radioproteção e Dosimetria Av. Salvador Allende, s/n, CEP 22780–160, Rio de Janeiro – RJ, Brazil / 2 Instituto de Biologia, Universidade do Estado do Rio de Janeiro Av. 28 de Setembro, 87, CEP 20551–030, Rio de Janeiro – RJ, Brazil/ 3 Departamento de Saúde, Fundação Oswaldo Cruz Av. Brasil, 4365, CEP 21045–900, Rio de Janeiro – RJ, BrazilInstituto de Radioproteção e Dosimetria. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnologia em Saúde. Rio de Janeiro, RJ, Brasil.Models for simulating radionuclide distribution in the human body involve assumptions on the biokinetic behaviour of the material. An important problem in biokinetic modelling is the correct assignment of transfer coefficients and biological half-lives to tissue compartments. The purpose of this study is the analysis of the variations of the radionuclide contents in the tissue compartments related to variations in the transfer coefficients from blood to the compartments and to variations in the compartments' biological half-lives. A generalised systemic recycling model, consisting of four tissue compartments and two excretion pathways, was used for the parametric analysis. A continuous intake directly to the blood was chosen for this study. Activities in the compartments were calculated for different times, following random selection of the transfer coefficients and half-lives. A computer code was developed to perform the random selection of parameters. Three different case studies were analysed, where different intervals of variation of half-lives in the four compartments were chosen: (a) the same range of variation was assigned to all compartments, (b) the intervals were chosen so that one compartment had a significantly longer half-life than the others, and (c) one compartment had a significantly shorter half-life than the others. Two cases for the intervals of variation of the transfer coefficients were investigated: (a) the same range for the variation of all transfer coefficients from blood to compartments was assumed, and (b) the interval of the variation of one transfer coefficient was significantly larger than the others. A multiple regression analysis method was applied to analyse the results. In this paper the detailed results of the parametric analysis are presented.engOxford University PressRadionuclídeosTransfusão de SangueModelo bioquímicoParametric analysis of a biokinetic model: a contribution to the study of model reliabilityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTLANDMANN_Parametric Analysis Biokinetic_1998.pdf.txtLANDMANN_Parametric Analysis Biokinetic_1998.pdf.txtExtracted texttext/plain18964https://www.arca.fiocruz.br/bitstream/icict/659/6/LANDMANN_Parametric%20Analysis%20Biokinetic_1998.pdf.txt975c80c3c78043ba2e4e350c29e13c6cMD56ORIGINALLANDMANN_Parametric Analysis Biokinetic_1998.pdfapplication/pdf34180https://www.arca.fiocruz.br/bitstream/icict/659/2/LANDMANN_Parametric%20Analysis%20Biokinetic_1998.pdf8316bfeb8d5f44135fb59e8aa558ce3fMD52LICENSElicense.txttext/plain1848https://www.arca.fiocruz.br/bitstream/icict/659/3/license.txtc1e4622844147e1ffa7fb904370b866aMD53THUMBNAILLANDMANN_Parametric Analysis Biokinetic_1998.pdf.jpgLANDMANN_Parametric Analysis Biokinetic_1998.pdf.jpgGenerated Thumbnailimage/jpeg2294https://www.arca.fiocruz.br/bitstream/icict/659/5/LANDMANN_Parametric%20Analysis%20Biokinetic_1998.pdf.jpg4d584742c1cb47f28a84f935cbfc2f50MD55icict/6592023-08-03 11:44:37.289oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-03T14:44:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Parametric analysis of a biokinetic model: a contribution to the study of model reliability
title Parametric analysis of a biokinetic model: a contribution to the study of model reliability
spellingShingle Parametric analysis of a biokinetic model: a contribution to the study of model reliability
Lourenço, M. C.
Radionuclídeos
Transfusão de Sangue
Modelo bioquímico
title_short Parametric analysis of a biokinetic model: a contribution to the study of model reliability
title_full Parametric analysis of a biokinetic model: a contribution to the study of model reliability
title_fullStr Parametric analysis of a biokinetic model: a contribution to the study of model reliability
title_full_unstemmed Parametric analysis of a biokinetic model: a contribution to the study of model reliability
title_sort Parametric analysis of a biokinetic model: a contribution to the study of model reliability
author Lourenço, M. C.
author_facet Lourenço, M. C.
Lipsztein, J. L.
Szwarcwald, Celia Landmann
author_role author
author2 Lipsztein, J. L.
Szwarcwald, Celia Landmann
author2_role author
author
dc.contributor.author.fl_str_mv Lourenço, M. C.
Lipsztein, J. L.
Szwarcwald, Celia Landmann
dc.subject.por.fl_str_mv Radionuclídeos
Transfusão de Sangue
Modelo bioquímico
topic Radionuclídeos
Transfusão de Sangue
Modelo bioquímico
description I M. C. Lourenc, II J. L. Lipsztein and III C. L. Szwarcwald/ 1 Instituto de Radioproteção e Dosimetria Av. Salvador Allende, s/n, CEP 22780–160, Rio de Janeiro – RJ, Brazil / 2 Instituto de Biologia, Universidade do Estado do Rio de Janeiro Av. 28 de Setembro, 87, CEP 20551–030, Rio de Janeiro – RJ, Brazil/ 3 Departamento de Saúde, Fundação Oswaldo Cruz Av. Brasil, 4365, CEP 21045–900, Rio de Janeiro – RJ, Brazil
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2010-08-23T16:58:36Z
2010-11-04T14:20:03Z
dc.date.available.fl_str_mv 2010-11-04T14:20:03Z
2010-08-23T16:58:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LOURENÇO, M. C.; LIPSZTEIN, J. L.; SZWARCWALD, C. L. Parametric analysis of a biokinetic model: a contribution to the study of model reliability. Radiation Protection Dosimetry, v. 79, p. 205-209, 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/659
dc.identifier.issn.pt_BR.fl_str_mv 1742-3406
identifier_str_mv LOURENÇO, M. C.; LIPSZTEIN, J. L.; SZWARCWALD, C. L. Parametric analysis of a biokinetic model: a contribution to the study of model reliability. Radiation Protection Dosimetry, v. 79, p. 205-209, 1998.
1742-3406
url https://www.arca.fiocruz.br/handle/icict/659
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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