Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24968 |
Resumo: | DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Campos, Cecilia Bonolo deDamasceno, Karine AraujoGamba, Conrado de OliveiraRibeiro, Ana MMachado, Carla JorgeLavalle, Gleidice EuniceCassali, Geovanni Dantas2018-02-27T14:33:36Z2018-02-27T14:33:36Z2016CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016.1098-612Xhttps://www.arca.fiocruz.br/handle/icict/2496810.1177/1098612X15610367DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento e Pesquisa (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).Veterinary Sciences of the Sao Paulo State University. School of Agricultural. Department of Veterinary Clinic and Surgery. Jaboticabal, SP, Brazil / Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Faculty of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Veterinary Hospital. Veterinary School. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilThe aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Objectives The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Methods Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic factors with OS. Results Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (P = 0.046) and COX-2 (P = 0.007) was higher in metastases than in primary tumors. COX-2 (P = 0.089), HER-2 (P = 0.012) and histologic grade (P = 0.080) were correlated with OS. Conclusions and relevance The data suggest that inhibition of ovarian hormones and COX-2 may represent a therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2 scores and Ki-67 index should be analyzed in primary tumors and metastases. histologic grade, HER-2 status and COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.engSAGE PublicationsNeoplasia malignaNeoplasias mamáriasMetástase linfáticaPrognosticoAnimaisMalignant neoplasmsBreast neoplasmLymphatic MetastasisPrognosisAnimalsEvaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasmsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24968/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCampos CB Evaluation of prognostic factors and survival....pdfCampos CB Evaluation of prognostic factors and 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dc.title.pt_BR.fl_str_mv |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
title |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
spellingShingle |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms Campos, Cecilia Bonolo de Neoplasia maligna Neoplasias mamárias Metástase linfática Prognostico Animais Malignant neoplasms Breast neoplasm Lymphatic Metastasis Prognosis Animals |
title_short |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
title_full |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
title_fullStr |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
title_full_unstemmed |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
title_sort |
Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms |
author |
Campos, Cecilia Bonolo de |
author_facet |
Campos, Cecilia Bonolo de Damasceno, Karine Araujo Gamba, Conrado de Oliveira Ribeiro, Ana M Machado, Carla Jorge Lavalle, Gleidice Eunice Cassali, Geovanni Dantas |
author_role |
author |
author2 |
Damasceno, Karine Araujo Gamba, Conrado de Oliveira Ribeiro, Ana M Machado, Carla Jorge Lavalle, Gleidice Eunice Cassali, Geovanni Dantas |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Campos, Cecilia Bonolo de Damasceno, Karine Araujo Gamba, Conrado de Oliveira Ribeiro, Ana M Machado, Carla Jorge Lavalle, Gleidice Eunice Cassali, Geovanni Dantas |
dc.subject.other.pt_BR.fl_str_mv |
Neoplasia maligna Neoplasias mamárias Metástase linfática Prognostico Animais |
topic |
Neoplasia maligna Neoplasias mamárias Metástase linfática Prognostico Animais Malignant neoplasms Breast neoplasm Lymphatic Metastasis Prognosis Animals |
dc.subject.en.pt_BR.fl_str_mv |
Malignant neoplasms Breast neoplasm Lymphatic Metastasis Prognosis Animals |
description |
DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-02-27T14:33:36Z |
dc.date.available.fl_str_mv |
2018-02-27T14:33:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/24968 |
dc.identifier.issn.pt_BR.fl_str_mv |
1098-612X |
dc.identifier.doi.none.fl_str_mv |
10.1177/1098612X15610367 |
identifier_str_mv |
CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016. 1098-612X 10.1177/1098612X15610367 |
url |
https://www.arca.fiocruz.br/handle/icict/24968 |
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eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
SAGE Publications |
publisher.none.fl_str_mv |
SAGE Publications |
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