Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms

Detalhes bibliográficos
Autor(a) principal: Campos, Cecilia Bonolo de
Data de Publicação: 2016
Outros Autores: Damasceno, Karine Araujo, Gamba, Conrado de Oliveira, Ribeiro, Ana M, Machado, Carla Jorge, Lavalle, Gleidice Eunice, Cassali, Geovanni Dantas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24968
Resumo: DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Campos, Cecilia Bonolo deDamasceno, Karine AraujoGamba, Conrado de OliveiraRibeiro, Ana MMachado, Carla JorgeLavalle, Gleidice EuniceCassali, Geovanni Dantas2018-02-27T14:33:36Z2018-02-27T14:33:36Z2016CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016.1098-612Xhttps://www.arca.fiocruz.br/handle/icict/2496810.1177/1098612X15610367DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento e Pesquisa (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).Veterinary Sciences of the Sao Paulo State University. School of Agricultural. Department of Veterinary Clinic and Surgery. Jaboticabal, SP, Brazil / Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Faculty of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Veterinary Hospital. Veterinary School. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, BrazilThe aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Objectives The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Methods Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic factors with OS. Results Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (P = 0.046) and COX-2 (P = 0.007) was higher in metastases than in primary tumors. COX-2 (P = 0.089), HER-2 (P = 0.012) and histologic grade (P = 0.080) were correlated with OS. Conclusions and relevance The data suggest that inhibition of ovarian hormones and COX-2 may represent a therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2 scores and Ki-67 index should be analyzed in primary tumors and metastases. histologic grade, HER-2 status and COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.engSAGE PublicationsNeoplasia malignaNeoplasias mamáriasMetástase linfáticaPrognosticoAnimaisMalignant neoplasmsBreast neoplasmLymphatic MetastasisPrognosisAnimalsEvaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasmsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24968/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCampos CB Evaluation of prognostic factors and survival....pdfCampos CB Evaluation of prognostic factors and 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dc.title.pt_BR.fl_str_mv Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
title Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
spellingShingle Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
Campos, Cecilia Bonolo de
Neoplasia maligna
Neoplasias mamárias
Metástase linfática
Prognostico
Animais
Malignant neoplasms
Breast neoplasm
Lymphatic Metastasis
Prognosis
Animals
title_short Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
title_full Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
title_fullStr Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
title_full_unstemmed Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
title_sort Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
author Campos, Cecilia Bonolo de
author_facet Campos, Cecilia Bonolo de
Damasceno, Karine Araujo
Gamba, Conrado de Oliveira
Ribeiro, Ana M
Machado, Carla Jorge
Lavalle, Gleidice Eunice
Cassali, Geovanni Dantas
author_role author
author2 Damasceno, Karine Araujo
Gamba, Conrado de Oliveira
Ribeiro, Ana M
Machado, Carla Jorge
Lavalle, Gleidice Eunice
Cassali, Geovanni Dantas
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Campos, Cecilia Bonolo de
Damasceno, Karine Araujo
Gamba, Conrado de Oliveira
Ribeiro, Ana M
Machado, Carla Jorge
Lavalle, Gleidice Eunice
Cassali, Geovanni Dantas
dc.subject.other.pt_BR.fl_str_mv Neoplasia maligna
Neoplasias mamárias
Metástase linfática
Prognostico
Animais
topic Neoplasia maligna
Neoplasias mamárias
Metástase linfática
Prognostico
Animais
Malignant neoplasms
Breast neoplasm
Lymphatic Metastasis
Prognosis
Animals
dc.subject.en.pt_BR.fl_str_mv Malignant neoplasms
Breast neoplasm
Lymphatic Metastasis
Prognosis
Animals
description DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2018-02-27T14:33:36Z
dc.date.available.fl_str_mv 2018-02-27T14:33:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24968
dc.identifier.issn.pt_BR.fl_str_mv 1098-612X
dc.identifier.doi.none.fl_str_mv 10.1177/1098612X15610367
identifier_str_mv CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016.
1098-612X
10.1177/1098612X15610367
url https://www.arca.fiocruz.br/handle/icict/24968
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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