Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Pereira, Thiago de Almeida; Syn, Wing-Kin; Machado, Mariana V; Vidigal, Paula Vieira Teixeira; Resende, Vivian; Teixeira, Izabela Voieta da Silva; Xie, Guanhua; Otoni, Alba; Souza, Márcia Maria de; Santos, Elisângela Trindade; Chan, Isaac S; Trindade, Guilherme Vaz de Melo; Choi, Steve S; Witek, Rafal P; Pereira, Fausto Edmundo Lima; Secor, William E; Andrade, Zilton de Araújo; Lambertucci, José Roberto; Diehl, Anna Mae

Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal:	Pereira, Thiago de Almeida
Data de Publicação:	2015
Outros Autores:	Syn, Wing-Kin, Machado, Mariana V, Vidigal, Paula Vieira Teixeira, Resende, Vivian, Teixeira, Izabela Voieta da Silva, Xie, Guanhua, Otoni, Alba, Souza, Márcia Maria de, Santos, Elisângela Trindade, Chan, Isaac S, Trindade, Guilherme Vaz de Melo, Choi, Steve S, Witek, Rafal P, Pereira, Fausto Edmundo Lima, Secor, William E, Andrade, Zilton de Araújo, Lambertucci, José Roberto, Diehl, Anna Mae
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/22796
Resumo:	Andrade, Zilton de Araújo† Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil Wing-Kin Syn‡§, Mariana V. Machado, Paula V. Vidigal , Vivian Resende , Izabela Voieta , Guanhua Xie, Alba Otoni , M´arcia M. Souza†, Elisˆangela T. Santos†, Isaac S. Chan, Guilherme V.M. Trindade , Steve S. Choi, Rafal P. Witek¶, Fausto E. Pereira, William E. Secor††, Zilton A. Andrade†, Jos´e Roberto Lambertucci and Anna Mae Diehl Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, U.S.A. †Laborat´orio de Patologia Experimental, Centro de Pesquisas Gonc¸alo Moniz/FIOCRUZ, Salvador, BA 40296-710, Brazil ‡Liver Regeneration and Repair Research Group, Institute of Hepatology, Foundation for Liver Research, London WC1E 6HX, U.K. §Department of Surgery, Loyola University, Chicago, Maywood, IL 60153, U.S.A. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG 30130-100, Brazil ¶Life Technologies, Frederick, MD 21704, U.S.A. *Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES 29040-091, Brazil ††Centers for Disease Control and Prevention, Atlanta, GA 30329, U.S.A.

Metadados do item

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spelling	Pereira, Thiago de AlmeidaSyn, Wing-KinMachado, Mariana VVidigal, Paula Vieira TeixeiraResende, VivianTeixeira, Izabela Voieta da SilvaXie, GuanhuaOtoni, AlbaSouza, Márcia Maria deSantos, Elisângela TrindadeChan, Isaac STrindade, Guilherme Vaz de MeloChoi, Steve SWitek, Rafal PPereira, Fausto Edmundo LimaSecor, William EAndrade, Zilton de AraújoLambertucci, José RobertoDiehl, Anna Mae2017-10-09T14:17:16Z2017-10-09T14:17:16Z2015PEREIRA, T. A. et al. Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clinical Science, v. 129, p. 875–883, 2015.0143-5221https://www.arca.fiocruz.br/handle/icict/2279610.1042/CS20150117Andrade, Zilton de Araújo† Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil Wing-Kin Syn‡§, Mariana V. Machado, Paula V. Vidigal , Vivian Resende , Izabela Voieta , Guanhua Xie, Alba Otoni , M´arcia M. Souza†, Elisˆangela T. Santos†, Isaac S. Chan, Guilherme V.M. Trindade , Steve S. Choi, Rafal P. Witek¶, Fausto E. Pereira, William E. Secor††, Zilton A. Andrade†, Jos´e Roberto Lambertucci and Anna Mae Diehl Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, U.S.A. †Laborat´orio de Patologia Experimental, Centro de Pesquisas Gonc¸alo Moniz/FIOCRUZ, Salvador, BA 40296-710, Brazil ‡Liver Regeneration and Repair Research Group, Institute of Hepatology, Foundation for Liver Research, London WC1E 6HX, U.K. §Department of Surgery, Loyola University, Chicago, Maywood, IL 60153, U.S.A. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG 30130-100, Brazil ¶Life Technologies, Frederick, MD 21704, U.S.A. *Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES 29040-091, Brazil ††Centers for Disease Control and Prevention, Atlanta, GA 30329, U.S.A.National Institutes of Health [grant number RO1-DK-077794 (to A.M.D.)]; the Duke University Endowment [the Florence McAlister Professorship (to A.M.D.)]; the Federal Council for Research and Development (to F.E.P., J.R.L., T.A.P. and Z.A.A.); and the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) (to J.R.L.).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilMúltipla - ver em NotasSchistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. We evaluated the hypothesis that schistosome eggs release factors that directly stimulate liver cells to produce osteopontin (OPN), a pro-fibrogenic protein that stimulates hepatic stellate cells to become myofibroblasts. We also investigated the utility of OPN as a biomarker of fibrosis and/or severity of portal hypertension. Cultured cholangiocytes, Kupffer cells and hepatic stellate cells were treated with soluble egg antigen (SEA); OPN production was quantified by quantitative reverse transcriptase polymerase chain reaction (qRTPCR) and ELISA; cell proliferation was assessed by BrdU (5-bromo-2'-deoxyuridine). Mice were infected with Schistosoma mansoni for 6 or 16 weeks to cause early or advanced fibrosis. Liver OPN was evaluated by qRTPCR and immunohistochemistry (IHC) and correlated with liver fibrosis and serum OPN. Livers from patients with schistosomiasis mansoni (early fibrosis n=15; advanced fibrosis n=72) or healthy adults (n=22) were immunostained for OPN and fibrosis markers. Results were correlated with plasma OPN levels and splenic vein pressures. SEA-induced cholangiocyte proliferation and OPN secretion (P<0.001 compared with controls). Cholangiocytes were OPN (+) in Schistosoma-infected mice and humans. Liver and serum OPN levels correlated with fibrosis stage (mice: r=0.861; human r=0.672, P=0.0001) and myofibroblast accumulation (mice: r=0.800; human: r=0.761, P=0.0001). Numbers of OPN (+) bile ductules strongly correlated with splenic vein pressure (r=0.778; P=0.001). S. mansoni egg antigens stimulate cholangiocyte proliferation and OPN secretion. OPN levels in liver and blood correlate with fibrosis stage and portal hypertension severity.engPortland PressColangiócitosProliferação ductularOsteopontinaHipertensão portalEsquistossomose mansônicaFibrose de SymmersCholangiocyteDuctular proliferationOsteopontinPortal hypertensionSchistosomiasis mansoniSymmers’ fibrosisSchistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22796/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPereira TA Schistosome-induced...Clin Scien 2015 v.129 p.875.pdfPereira TA Schistosome-induced...Clin Scien 2015 v.129 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dc.title.pt_BR.fl_str_mv	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
title	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
spellingShingle	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni Pereira, Thiago de Almeida Colangiócitos Proliferação ductular Osteopontina Hipertensão portal Esquistossomose mansônica Fibrose de Symmers Cholangiocyte Ductular proliferation Osteopontin Portal hypertension Schistosomiasis mansoni Symmers’ fibrosis
title_short	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
title_full	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
title_fullStr	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
title_full_unstemmed	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
title_sort	Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni
author	Pereira, Thiago de Almeida
author_facet	Pereira, Thiago de Almeida Syn, Wing-Kin Machado, Mariana V Vidigal, Paula Vieira Teixeira Resende, Vivian Teixeira, Izabela Voieta da Silva Xie, Guanhua Otoni, Alba Souza, Márcia Maria de Santos, Elisângela Trindade Chan, Isaac S Trindade, Guilherme Vaz de Melo Choi, Steve S Witek, Rafal P Pereira, Fausto Edmundo Lima Secor, William E Andrade, Zilton de Araújo Lambertucci, José Roberto Diehl, Anna Mae
author_role	author
author2	Syn, Wing-Kin Machado, Mariana V Vidigal, Paula Vieira Teixeira Resende, Vivian Teixeira, Izabela Voieta da Silva Xie, Guanhua Otoni, Alba Souza, Márcia Maria de Santos, Elisângela Trindade Chan, Isaac S Trindade, Guilherme Vaz de Melo Choi, Steve S Witek, Rafal P Pereira, Fausto Edmundo Lima Secor, William E Andrade, Zilton de Araújo Lambertucci, José Roberto Diehl, Anna Mae
author2_role	author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Pereira, Thiago de Almeida Syn, Wing-Kin Machado, Mariana V Vidigal, Paula Vieira Teixeira Resende, Vivian Teixeira, Izabela Voieta da Silva Xie, Guanhua Otoni, Alba Souza, Márcia Maria de Santos, Elisângela Trindade Chan, Isaac S Trindade, Guilherme Vaz de Melo Choi, Steve S Witek, Rafal P Pereira, Fausto Edmundo Lima Secor, William E Andrade, Zilton de Araújo Lambertucci, José Roberto Diehl, Anna Mae
dc.subject.other.pt_BR.fl_str_mv	Colangiócitos Proliferação ductular Osteopontina Hipertensão portal Esquistossomose mansônica Fibrose de Symmers
topic	Colangiócitos Proliferação ductular Osteopontina Hipertensão portal Esquistossomose mansônica Fibrose de Symmers Cholangiocyte Ductular proliferation Osteopontin Portal hypertension Schistosomiasis mansoni Symmers’ fibrosis
dc.subject.en.pt_BR.fl_str_mv	Cholangiocyte Ductular proliferation Osteopontin Portal hypertension Schistosomiasis mansoni Symmers’ fibrosis
description	Andrade, Zilton de Araújo† Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil Wing-Kin Syn‡§, Mariana V. Machado, Paula V. Vidigal , Vivian Resende , Izabela Voieta , Guanhua Xie, Alba Otoni , M´arcia M. Souza†, Elisˆangela T. Santos†, Isaac S. Chan, Guilherme V.M. Trindade , Steve S. Choi, Rafal P. Witek¶, Fausto E. Pereira, William E. Secor††, Zilton A. Andrade†, Jos´e Roberto Lambertucci and Anna Mae Diehl Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, U.S.A. †Laborat´orio de Patologia Experimental, Centro de Pesquisas Gonc¸alo Moniz/FIOCRUZ, Salvador, BA 40296-710, Brazil ‡Liver Regeneration and Repair Research Group, Institute of Hepatology, Foundation for Liver Research, London WC1E 6HX, U.K. §Department of Surgery, Loyola University, Chicago, Maywood, IL 60153, U.S.A. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG 30130-100, Brazil ¶Life Technologies, Frederick, MD 21704, U.S.A. *Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES 29040-091, Brazil ††Centers for Disease Control and Prevention, Atlanta, GA 30329, U.S.A.
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2017-10-09T14:17:16Z
dc.date.available.fl_str_mv	2017-10-09T14:17:16Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PEREIRA, T. A. et al. Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clinical Science, v. 129, p. 875–883, 2015.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/22796
dc.identifier.issn.pt_BR.fl_str_mv	0143-5221
dc.identifier.doi.none.fl_str_mv	10.1042/CS20150117
identifier_str_mv	PEREIRA, T. A. et al. Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clinical Science, v. 129, p. 875–883, 2015. 0143-5221 10.1042/CS20150117
url	https://www.arca.fiocruz.br/handle/icict/22796
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Portland Press
publisher.none.fl_str_mv	Portland Press
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

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