Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19342 |
Resumo: | Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil. |
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Araújo-Mariz, CarollineLopes, Edmundo PessoaAcioli-Santos, BartolomeuMaruza, MagdaMontarroyos, Ulisses RamosXimenes, Ricardo Arraes de AlencarLacerda, Heloísa RamosMiranda-Filho, Demócrito de BarrosAlbuquerque, Maria de Fátima Pessoa Militão de2017-06-07T18:36:43Z2017-06-07T18:36:43Z2016ARAÚJO-MARIZ, Caroline et al. Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. Plos One, v. 11, n. 6, p. 1-15, 22 jun. 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1934210.1371/journal.pone.0157725engTuberculoseHepatotoxicidadeHIVAIDSSíndrome de Imunodeficiência Adquirida / complicaçõesAntituberculosos / efeitos adversosAntituberculosos / uso terapêuticoLesão Hepática Induzida por Substâncias Químicas e Medicamentosas / patologiaTuberculose / complicaçõesTuberculose / quimioterapiaHepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia. Recife, PE, Brasil.Secretaria de Saúde de Pernambuco. Hospital Correia Picanço. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil.Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living with HIV/AIDS (PLWHA) start treatment for tuberculosis. This was a prospective cohort study with PLWHA who were monitored during the first 60 days of tuberculosis treatment in Pernambuco, Brazil. Hepatotoxicity was considered increased levels of aminotransferase, namely those that rose to three times higher than the level before initiating tuberculosis treatment, these levels being associated with symptoms of hepatitis. We conducted a multivariate logistic regression analysis and the magnitude of the associations was expressed by the odds ratio with a confidence interval of 95%. Hepatotoxicity was observed in 53 (30.6%) of the 173 patients who started tuberculosis treatment. The final multivariate logistic regression model demonstrated that the use of fluconazole, malnutrition and the subject being classified as a phenotypically slow acetylator increased the risk of hepatotoxicity significantly. The incidence of hepatotoxicity during treatment for tuberculosis in PLWHA was high. Those classified as phenotypically slow acetylators and as malnourished should be targeted for specific care to reduce the risk of hepatotoxicity during treatment for tuberculosis. The use of fluconazole should be avoided during tuberculosis treatment in PLWHA.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19342/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL27332812 2016 ara-hep.oa.PDF27332812 2016 ara-hep.oa.PDFapplication/pdf721009https://www.arca.fiocruz.br/bitstream/icict/19342/2/27332812%202016%20ara-hep.oa.PDF325c6d1b4407580d9ce662bb8f85efd4MD52TEXT27332812 2016 ara-hep.oa.PDF.txt27332812 2016 ara-hep.oa.PDF.txtExtracted texttext/plain49909https://www.arca.fiocruz.br/bitstream/icict/19342/3/27332812%202016%20ara-hep.oa.PDF.txtf316c533ce4a82b6ab5f97659af8b218MD53icict/193422019-04-02 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| dc.title.pt_BR.fl_str_mv |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| title |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| spellingShingle |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS Araújo-Mariz, Carolline Tuberculose Hepatotoxicidade HIV AIDS Síndrome de Imunodeficiência Adquirida / complicações Antituberculosos / efeitos adversos Antituberculosos / uso terapêutico Lesão Hepática Induzida por Substâncias Químicas e Medicamentosas / patologia Tuberculose / complicações Tuberculose / quimioterapia |
| title_short |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| title_full |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| title_fullStr |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| title_full_unstemmed |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| title_sort |
Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS |
| author |
Araújo-Mariz, Carolline |
| author_facet |
Araújo-Mariz, Carolline Lopes, Edmundo Pessoa Acioli-Santos, Bartolomeu Maruza, Magda Montarroyos, Ulisses Ramos Ximenes, Ricardo Arraes de Alencar Lacerda, Heloísa Ramos Miranda-Filho, Demócrito de Barros Albuquerque, Maria de Fátima Pessoa Militão de |
| author_role |
author |
| author2 |
Lopes, Edmundo Pessoa Acioli-Santos, Bartolomeu Maruza, Magda Montarroyos, Ulisses Ramos Ximenes, Ricardo Arraes de Alencar Lacerda, Heloísa Ramos Miranda-Filho, Demócrito de Barros Albuquerque, Maria de Fátima Pessoa Militão de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Araújo-Mariz, Carolline Lopes, Edmundo Pessoa Acioli-Santos, Bartolomeu Maruza, Magda Montarroyos, Ulisses Ramos Ximenes, Ricardo Arraes de Alencar Lacerda, Heloísa Ramos Miranda-Filho, Demócrito de Barros Albuquerque, Maria de Fátima Pessoa Militão de |
| dc.subject.other.none.fl_str_mv |
Tuberculose Hepatotoxicidade HIV AIDS |
| topic |
Tuberculose Hepatotoxicidade HIV AIDS Síndrome de Imunodeficiência Adquirida / complicações Antituberculosos / efeitos adversos Antituberculosos / uso terapêutico Lesão Hepática Induzida por Substâncias Químicas e Medicamentosas / patologia Tuberculose / complicações Tuberculose / quimioterapia |
| dc.subject.decs.none.fl_str_mv |
Síndrome de Imunodeficiência Adquirida / complicações Antituberculosos / efeitos adversos Antituberculosos / uso terapêutico Lesão Hepática Induzida por Substâncias Químicas e Medicamentosas / patologia Tuberculose / complicações Tuberculose / quimioterapia |
| description |
Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil. |
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2016 |
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2016 |
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2017-06-07T18:36:43Z |
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2017-06-07T18:36:43Z |
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ARAÚJO-MARIZ, Caroline et al. Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. Plos One, v. 11, n. 6, p. 1-15, 22 jun. 2016. |
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https://www.arca.fiocruz.br/handle/icict/19342 |
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1932-6203 |
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10.1371/journal.pone.0157725 |
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ARAÚJO-MARIZ, Caroline et al. Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. Plos One, v. 11, n. 6, p. 1-15, 22 jun. 2016. 1932-6203 10.1371/journal.pone.0157725 |
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