HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16521 |
Resumo: | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil. |
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Pacheco, Antonio G.Grinsztejn, BeatrizFonseca, Maria de Jesus M. daGriep, Rosane HarterLotufo, PauloBensenor, IsabelaMill, José G.Moreira, Rodrigo de C.Moreira, Ronaldo I.Friedman, Ruth K.Oliveira, Marilia SantiniCardoso, Sandra W.Veloso, Valdiléa G.Chor, Dóra2016-12-13T14:54:06Z2016-12-13T14:54:06Z2016PACHECO, Antonio G. et al. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross- Sectional Analysis from the INI/ELSA-Brasil Study. Plos One, v. 11, n. 7, p. 1-12, July 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1652110.1371/journal.pone.0158999engPublic Library of ScienceCarótidaInfeção por HIVEspessuraEstudo ELSA-BrasilDoença ateroscleróticaCarotid Intima-Media ThicknessINI/ELSA-Brasil StudyHIV InfectionBrazilatherosclerotic diseaseHIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina. São Paulo, SP, Brasil.Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.Background: Carotid intima-media thickness (cIMT) has been used as an early marker of atherosclerotic disease in the general population. Recently its role among HIV-infected patients has been questioned. To date, no Brazilian study has compared cIMT in respect to HIV status. Methods We compared data from 535 patients actively followed in a prospective cohort in Rio de Janeiro (HIV group); 88 HIV-negative individuals who were nominated by patients (friend controls–FCs); and 10,943 participants of the ELSA-Brasil study. Linear regression models were used to study associations of the 3 groups and several covariables with cIMT. Propensity scores weighting (PSW) were also employed to balance data. Results: Median thickness in mm (IQR) were 0.54 (0.49,0.62); 0.58 (0.52,0.68); and 0.57 (0.49,0.70), HIV, FCs and ELSA-Brasil groups, respectively (p-value<0.001). The best linear model chosen did not include the group variables, after adjusting for all the variables chosen, showing no difference of cIMT across groups. Similar results were obtained with PSW. Several traditional CVD risk factors were also significantly associated with cIMT: female gender, higher education and higher HDL were negatively associated while risk factors were older age, current/former smoker, AMI/stroke family history, CVD history, hypertension, DM, higher BMI and total cholesterol.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16521/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrosane2_griep_etal_IOC_2016.pdfrosane2_griep_etal_IOC_2016.pdfapplication/pdf225670https://www.arca.fiocruz.br/bitstream/icict/16521/2/rosane2_griep_etal_IOC_2016.pdf18e069cd0a23fa3bd6ac37e3a511d24fMD52TEXTrosane2_griep_etal_IOC_2016.pdf.txtrosane2_griep_etal_IOC_2016.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| title |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| spellingShingle |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study Pacheco, Antonio G. Carótida Infeção por HIV Espessura Estudo ELSA-Brasil Doença aterosclerótica Carotid Intima-Media Thickness INI/ELSA-Brasil Study HIV Infection Brazil atherosclerotic disease |
| title_short |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| title_full |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| title_fullStr |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| title_full_unstemmed |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| title_sort |
HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study |
| author |
Pacheco, Antonio G. |
| author_facet |
Pacheco, Antonio G. Grinsztejn, Beatriz Fonseca, Maria de Jesus M. da Griep, Rosane Harter Lotufo, Paulo Bensenor, Isabela Mill, José G. Moreira, Rodrigo de C. Moreira, Ronaldo I. Friedman, Ruth K. Oliveira, Marilia Santini Cardoso, Sandra W. Veloso, Valdiléa G. Chor, Dóra |
| author_role |
author |
| author2 |
Grinsztejn, Beatriz Fonseca, Maria de Jesus M. da Griep, Rosane Harter Lotufo, Paulo Bensenor, Isabela Mill, José G. Moreira, Rodrigo de C. Moreira, Ronaldo I. Friedman, Ruth K. Oliveira, Marilia Santini Cardoso, Sandra W. Veloso, Valdiléa G. Chor, Dóra |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pacheco, Antonio G. Grinsztejn, Beatriz Fonseca, Maria de Jesus M. da Griep, Rosane Harter Lotufo, Paulo Bensenor, Isabela Mill, José G. Moreira, Rodrigo de C. Moreira, Ronaldo I. Friedman, Ruth K. Oliveira, Marilia Santini Cardoso, Sandra W. Veloso, Valdiléa G. Chor, Dóra |
| dc.subject.other.pt_BR.fl_str_mv |
Carótida Infeção por HIV Espessura Estudo ELSA-Brasil Doença aterosclerótica |
| topic |
Carótida Infeção por HIV Espessura Estudo ELSA-Brasil Doença aterosclerótica Carotid Intima-Media Thickness INI/ELSA-Brasil Study HIV Infection Brazil atherosclerotic disease |
| dc.subject.en.pt_BR.fl_str_mv |
Carotid Intima-Media Thickness INI/ELSA-Brasil Study HIV Infection Brazil atherosclerotic disease |
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Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil. |
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2016 |
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2016-12-13T14:54:06Z |
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2016-12-13T14:54:06Z |
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2016 |
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PACHECO, Antonio G. et al. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross- Sectional Analysis from the INI/ELSA-Brasil Study. Plos One, v. 11, n. 7, p. 1-12, July 2016. |
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https://www.arca.fiocruz.br/handle/icict/16521 |
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1932-6203 |
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10.1371/journal.pone.0158999 |
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PACHECO, Antonio G. et al. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross- Sectional Analysis from the INI/ELSA-Brasil Study. Plos One, v. 11, n. 7, p. 1-12, July 2016. 1932-6203 10.1371/journal.pone.0158999 |
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