Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia

Detalhes bibliográficos
Autor(a) principal: Gomes, Marisa Z. R.
Data de Publicação: 2014
Outros Autores: Jiang, Ying, Mulanovich, Victor E., Lewis, Russell E., Kontoyiannis, Dimitrios P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11068
Resumo: University of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
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spelling Gomes, Marisa Z. R.Jiang, YingMulanovich, Victor E.Lewis, Russell E.Kontoyiannis, Dimitrios P.2015-07-03T12:34:38Z2015-07-03T12:34:38Z2014GOMES, Marisa Z. R. et al. Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia. Antimicrobial Agents and Chemotherapy, v.58, n.5, p.2775-2780, may 2014.0066-4804https://www.arca.fiocruz.br/handle/icict/1106810.1128/AAC.01527-13engAmerican Society for MicrobiologyProfilaxiaAspergillusMyeloid LeukemiaChemotherapyPrimary Anti-Aspergillus ProphylaxisAspergillusLeucemia MieloideQuimioterapiaEffectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.University of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA.University of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA.University of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA.University of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA .Although antifungal prophylaxis is frequently administered to patients with acute myeloid leukemia (AML) during remissioninduction chemotherapy (RIC), its impact on reducing invasive fungal infections (IFIs) outside clinical trials is rarely reported. We performed a retrospective observational study to identify risk factors for development of IFIs (definite or probable, using revised European Organization for Research and Treatment of Cancer [EORTC] criteria) and all-cause mortality in a cohort of 152 AML patients receiving RIC (2009 to 2011). We also compared rates of IFI and mortality in patients who received echinocandin versus anti-Aspergillus azole (voriconazole or posaconazole) prophylaxis during the first 120 days of RIC. In multivariate analysis, clofarabine-based RIC (hazard ratio [HR], 3.5; 95% confidence interval [CI], 1.5 to 8.3; P 0.004) and echinocandin prophylaxis (HR, 4.6; 95% CI, 1.8 to 11.9; P 0.002) were independently associated with higher rates of IFI rates during RIC. Subsequent analysis failed to identify any malignancy- or chemotherapy-related covariates linked to echinocandin prophylaxis that accounted for the higher rates of breakthrough IFI. Although the possibility of other confounding variables cannot be excluded, our findings suggest that echinocandin-based prophylaxis during RIC for AML may be associated with a higher risk of breakthrough IFI.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11068/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALmarisa_gomesetal_IOC-2014.pdfapplication/pdf441383https://www.arca.fiocruz.br/bitstream/icict/11068/2/marisa_gomesetal_IOC-2014.pdf7751a331a864c81e4dce9826d881e5b1MD52TEXTmarisa_gomesetal_IOC-2014.pdf.txtmarisa_gomesetal_IOC-2014.pdf.txtExtracted texttext/plain37499https://www.arca.fiocruz.br/bitstream/icict/11068/3/marisa_gomesetal_IOC-2014.pdf.txt0a1fc5b9a5c6c7541fc572e142576830MD53icict/110682022-06-24 12:18:54.325oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:18:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
title Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
spellingShingle Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
Gomes, Marisa Z. R.
Profilaxia
Aspergillus
Myeloid Leukemia
Chemotherapy
Primary Anti-Aspergillus Prophylaxis
Aspergillus
Leucemia Mieloide
Quimioterapia
title_short Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
title_full Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
title_fullStr Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
title_full_unstemmed Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
title_sort Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia
author Gomes, Marisa Z. R.
author_facet Gomes, Marisa Z. R.
Jiang, Ying
Mulanovich, Victor E.
Lewis, Russell E.
Kontoyiannis, Dimitrios P.
author_role author
author2 Jiang, Ying
Mulanovich, Victor E.
Lewis, Russell E.
Kontoyiannis, Dimitrios P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Marisa Z. R.
Jiang, Ying
Mulanovich, Victor E.
Lewis, Russell E.
Kontoyiannis, Dimitrios P.
dc.subject.other.pt_BR.fl_str_mv Profilaxia
topic Profilaxia
Aspergillus
Myeloid Leukemia
Chemotherapy
Primary Anti-Aspergillus Prophylaxis
Aspergillus
Leucemia Mieloide
Quimioterapia
dc.subject.en.pt_BR.fl_str_mv Aspergillus
Myeloid Leukemia
Chemotherapy
Primary Anti-Aspergillus Prophylaxis
dc.subject.decs.pt_BR.fl_str_mv Aspergillus
Leucemia Mieloide
Quimioterapia
description University of Texas MD Anderson Cancer Center. Department of Infectious Diseases, Infection Control and Employee Health. Texas, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-07-03T12:34:38Z
dc.date.available.fl_str_mv 2015-07-03T12:34:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Marisa Z. R. et al. Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia. Antimicrobial Agents and Chemotherapy, v.58, n.5, p.2775-2780, may 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11068
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.pt_BR.fl_str_mv 10.1128/AAC.01527-13
identifier_str_mv GOMES, Marisa Z. R. et al. Effectiveness of Primary Anti-Aspergillus Prophylaxis during Remission Induction Chemotherapy of Acute Myeloid Leukemia. Antimicrobial Agents and Chemotherapy, v.58, n.5, p.2775-2780, may 2014.
0066-4804
10.1128/AAC.01527-13
url https://www.arca.fiocruz.br/handle/icict/11068
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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