Cutaneous Manifestations of Human and Murine Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Scorza, Breanna M
Data de Publicação: 2017
Outros Autores: Carvalho Filho, Edgar Marcelino, Wilson, Mary E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20038
Resumo: National Institutes of Health (NIH) grant AI076233, and by Merit Review grants 5I01BX001983-02 and 2I01BX000536 from the Department of Veterans’ Affairs (MEW). Studies were performed in part while B.M.S. was supported with funds from NIH T32 AI07511
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spelling Scorza, Breanna MCarvalho Filho, Edgar MarcelinoWilson, Mary E2017-07-11T13:42:16Z2017-07-11T13:42:16Z2017SCORZA, B. M.; CARVALHO FILHO, E. M.; WILSON, M. E. Cutaneous Manifestations of Human and Murine Leishmaniasis. International Journal of Molecular Sciences, v. 18, p. 1296, 2017.1661-6596https://www.arca.fiocruz.br/handle/icict/2003810.3390/ijms18061296National Institutes of Health (NIH) grant AI076233, and by Merit Review grants 5I01BX001983-02 and 2I01BX000536 from the Department of Veterans’ Affairs (MEW). Studies were performed in part while B.M.S. was supported with funds from NIH T32 AI07511University of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Salvador, BA, BrasilUniversity of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USA / University of Iowa. Department of Internal Medicine. Iowa City, IA, USA / University of Iowa. Department of Microbiology. Iowa City, IA, USA / Veterans’ Affairs Medical Center. Iowa City, IA, USAThe leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.engMDPILeishmaniaLeishmaniose cutâneaLeishmaniose mucosaLeishmaniose difusaLeishmaniose disseminadaPeleKala-azarImunologiaLeishmaniaCutaneous leishmaniasisMucosal leishmaniasisDiffuse leishmaniasisDisseminated leishmaniasisDTH-delayed type hypersensitivity skin testLST-Leishmania skin testPost-kala-azar dermal leishmaniasisKala-azarSkin immunologyCutaneous Manifestations of Human and Murine Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Cutaneous Manifestations of Human and Murine Leishmaniasis
title Cutaneous Manifestations of Human and Murine Leishmaniasis
spellingShingle Cutaneous Manifestations of Human and Murine Leishmaniasis
Scorza, Breanna M
Leishmania
Leishmaniose cutânea
Leishmaniose mucosa
Leishmaniose difusa
Leishmaniose disseminada
Pele
Kala-azar
Imunologia
Leishmania
Cutaneous leishmaniasis
Mucosal leishmaniasis
Diffuse leishmaniasis
Disseminated leishmaniasis
DTH-delayed type hypersensitivity skin test
LST-Leishmania skin test
Post-kala-azar dermal leishmaniasis
Kala-azar
Skin immunology
title_short Cutaneous Manifestations of Human and Murine Leishmaniasis
title_full Cutaneous Manifestations of Human and Murine Leishmaniasis
title_fullStr Cutaneous Manifestations of Human and Murine Leishmaniasis
title_full_unstemmed Cutaneous Manifestations of Human and Murine Leishmaniasis
title_sort Cutaneous Manifestations of Human and Murine Leishmaniasis
author Scorza, Breanna M
author_facet Scorza, Breanna M
Carvalho Filho, Edgar Marcelino
Wilson, Mary E
author_role author
author2 Carvalho Filho, Edgar Marcelino
Wilson, Mary E
author2_role author
author
dc.contributor.author.fl_str_mv Scorza, Breanna M
Carvalho Filho, Edgar Marcelino
Wilson, Mary E
dc.subject.other.pt_BR.fl_str_mv Leishmania
Leishmaniose cutânea
Leishmaniose mucosa
Leishmaniose difusa
Leishmaniose disseminada
Pele
Kala-azar
Imunologia
topic Leishmania
Leishmaniose cutânea
Leishmaniose mucosa
Leishmaniose difusa
Leishmaniose disseminada
Pele
Kala-azar
Imunologia
Leishmania
Cutaneous leishmaniasis
Mucosal leishmaniasis
Diffuse leishmaniasis
Disseminated leishmaniasis
DTH-delayed type hypersensitivity skin test
LST-Leishmania skin test
Post-kala-azar dermal leishmaniasis
Kala-azar
Skin immunology
dc.subject.en.pt_BR.fl_str_mv Leishmania
Cutaneous leishmaniasis
Mucosal leishmaniasis
Diffuse leishmaniasis
Disseminated leishmaniasis
DTH-delayed type hypersensitivity skin test
LST-Leishmania skin test
Post-kala-azar dermal leishmaniasis
Kala-azar
Skin immunology
description National Institutes of Health (NIH) grant AI076233, and by Merit Review grants 5I01BX001983-02 and 2I01BX000536 from the Department of Veterans’ Affairs (MEW). Studies were performed in part while B.M.S. was supported with funds from NIH T32 AI07511
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-07-11T13:42:16Z
dc.date.available.fl_str_mv 2017-07-11T13:42:16Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCORZA, B. M.; CARVALHO FILHO, E. M.; WILSON, M. E. Cutaneous Manifestations of Human and Murine Leishmaniasis. International Journal of Molecular Sciences, v. 18, p. 1296, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20038
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms18061296
identifier_str_mv SCORZA, B. M.; CARVALHO FILHO, E. M.; WILSON, M. E. Cutaneous Manifestations of Human and Murine Leishmaniasis. International Journal of Molecular Sciences, v. 18, p. 1296, 2017.
1661-6596
10.3390/ijms18061296
url https://www.arca.fiocruz.br/handle/icict/20038
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/20038/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/20038/2/Scorza%20BM%20Cutaneous%20manifestations....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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