Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.

Detalhes bibliográficos
Autor(a) principal: Bongertz, Vera
Data de Publicação: 1998
Outros Autores: Costa, Catia Ines, Guimarães, Monick Lindenmeyer, Grinsztejn, Beatriz, The HEC/FIOCRUZ Aids Clinical Research Group, João Filho, Esaú Custódio, Castro Filho, Bernardo Galvão, Morgado, Mariza Gonçalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8189
Resumo: AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil
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spelling Bongertz, VeraCosta, Catia InesGuimarães, Monick LindenmeyerGrinsztejn, BeatrizThe HEC/FIOCRUZ Aids Clinical Research GroupJoão Filho, Esaú CustódioCastro Filho, Bernardo GalvãoMorgado, Mariza Gonçalves2014-08-12T13:58:33Z2014-08-12T13:58:33Z1998BONGERTZ, V. et al. Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group. Scandinavian Journal of Immunology, v. 47, n. 6, p. 603-608, 1998.0300-9475https://www.arca.fiocruz.br/handle/icict/8189engBlackwell ScienceNeutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, BrasilAIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, BrasilAIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, BrasilServidores do Estado Hospital Rio de Janeiro. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilAIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, BrasilSusceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates belonging to subtype B, to the B"-variant of subtype B or to subtype F from infected individuals residing in Rio de Janeiro was assayed. A lower infectivity of the B"- and F isolates when compared to the classical B-subtype HIV-1 isolates was observed. Comparisons of neutralization susceptibilities were carried out for 19 B-subtype, 11 B"-variant and two F-subtype HIV-1 isolates with plasma from autologous and heterologous samples. Frequency of autologous neutralization was slightly lower for B-subtype isolates in comparison to B"-variant isolates. Heterologous intra-subtype neutralization was significantly lower for B-subtype than for the B"-variant or the F-subtype isolates. While B-subtype isolates were neutralized by most anti-F-subtype plasma, F-subtype isolates, although most susceptible to F-subtype antibodies, were highly susceptible to neutralization by anti-B-subtype antibodies. Cross-neutralization for B"-variant and B-subtype isolates was not as extensive as observed for B- and F-subtype isolates. However, the results presented indicate a quite extensive cross-neutralization between Brazilian HIV-1 isolates.Antígenos HIV/imunologiaHIV-1/imunologiaVariação AntigênicaAnticorpos Anti-HIV/imunologiaHIV-1/isolamento & purificaçãoTestes de NeutralizaçãoHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBongertz V Neutralization....pdfBongertz V Neutralization....pdfapplication/pdf117774https://www.arca.fiocruz.br/bitstream/icict/8189/1/Bongertz%20V%20Neutralization....pdf3b8595108e205935db0e283bb01847f4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8189/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBongertz V Neutralization....pdf.txtBongertz V Neutralization....pdf.txtExtracted texttext/plain28333https://www.arca.fiocruz.br/bitstream/icict/8189/3/Bongertz%20V%20Neutralization....pdf.txt95425aec392d9874a9d8902a0eb5ff85MD53icict/81892023-06-15 16:16:00.179oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-15T19:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
title Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
spellingShingle Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
Bongertz, Vera
Antígenos HIV/imunologia
HIV-1/imunologia
Variação Antigênica
Anticorpos Anti-HIV/imunologia
HIV-1/isolamento & purificação
Testes de Neutralização
Humanos
title_short Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
title_full Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
title_fullStr Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
title_full_unstemmed Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
title_sort Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.
author Bongertz, Vera
author_facet Bongertz, Vera
Costa, Catia Ines
Guimarães, Monick Lindenmeyer
Grinsztejn, Beatriz
The HEC/FIOCRUZ Aids Clinical Research Group
João Filho, Esaú Custódio
Castro Filho, Bernardo Galvão
Morgado, Mariza Gonçalves
author_role author
author2 Costa, Catia Ines
Guimarães, Monick Lindenmeyer
Grinsztejn, Beatriz
The HEC/FIOCRUZ Aids Clinical Research Group
João Filho, Esaú Custódio
Castro Filho, Bernardo Galvão
Morgado, Mariza Gonçalves
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bongertz, Vera
Costa, Catia Ines
Guimarães, Monick Lindenmeyer
Grinsztejn, Beatriz
The HEC/FIOCRUZ Aids Clinical Research Group
João Filho, Esaú Custódio
Castro Filho, Bernardo Galvão
Morgado, Mariza Gonçalves
dc.subject.decs.pt_BR.fl_str_mv Antígenos HIV/imunologia
HIV-1/imunologia
Variação Antigênica
Anticorpos Anti-HIV/imunologia
HIV-1/isolamento & purificação
Testes de Neutralização
Humanos
topic Antígenos HIV/imunologia
HIV-1/imunologia
Variação Antigênica
Anticorpos Anti-HIV/imunologia
HIV-1/isolamento & purificação
Testes de Neutralização
Humanos
description AIDS & Molecular Immunology Laboratory. Department of Immunology. Rio de Janeiro, RJ, Brasil
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2014-08-12T13:58:33Z
dc.date.available.fl_str_mv 2014-08-12T13:58:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONGERTZ, V. et al. Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group. Scandinavian Journal of Immunology, v. 47, n. 6, p. 603-608, 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8189
dc.identifier.issn.none.fl_str_mv 0300-9475
identifier_str_mv BONGERTZ, V. et al. Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group. Scandinavian Journal of Immunology, v. 47, n. 6, p. 603-608, 1998.
0300-9475
url https://www.arca.fiocruz.br/handle/icict/8189
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Science
publisher.none.fl_str_mv Blackwell Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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