Specific schistosomiasis treatment as a strategy for disease control

Detalhes bibliográficos
Autor(a) principal: Coura, José Rodrigues
Data de Publicação: 2010
Outros Autores: Conceição, Maria José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30313
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitáriasl. Rio de Janeiro, RJ. Brasil.
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spelling Coura, José RodriguesConceição, Maria José2018-11-29T13:34:54Z2018-11-29T13:34:54Z2010COURA, José Rodrigues; CONCEIÇÃO, Maria José. Specific schistosomiasis treatment as a strategy for disease control. Mem Inst Oswaldo Cruz, v.105, n.4, p.598-603, July 2010.0074-0276https://www.arca.fiocruz.br/handle/icict/303131678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzEsquistossomoseTratamento específicoTransmissãoControle da morbidadeschistosomiasisspecific treatmenttransmissionmorbidity controlSpecific schistosomiasis treatment as a strategy for disease controlinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitáriasl. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Serviço de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.The great hope for schistosomiasis treatment began with the development of oxamniquine and praziquantel. These drugs can be administered orally in a single dose and have a high curative power with minor side effects. In this study, we carried out a field experiment involving a population of 3,782 people. The population was examined at four localities in Minas Gerais within the valleys of the Doce and Jequitinhonha Rivers. In this cohort, there were 1,790 patients infected with Schistosoma mansoni (47.3%) and we showed that only 1,403 (78.4%) could be treated with oxamniquine in a single dose of 12.5-20 mg/kg orally. The other 387 (21.6%) were not treated during the first stage because of contraindications (pregnancy or impeditive diseases), absences or refusals. It was observed that, on average, 8.8-17% of the infected patients continued to excrete S. mansoni eggs at the end of the 2nd month after treatment and 30-32% of the cohort was infected by the end of the 24th month. In one of the areas that we followed-up for a total of 30 years, the prevalence of the infection with S. mansoni fell from 60.8-19.3% and the hepatosplenic form of the disease dropped from 5.8-1.3%. We conclude that specific treatment of schistosomiasis reduces the prevalence of infection in the short-term and the morbidity due to schistosomiasis in medium to long-term time frames, but does not help to control disease transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30313/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjosecoura_mariaconceicao_IOC_2010.pdfjosecoura_mariaconceicao_IOC_2010.pdfapplication/pdf550278https://www.arca.fiocruz.br/bitstream/icict/30313/2/josecoura_mariaconceicao_IOC_2010.pdfe8be0ed78a4183ca5d8459cbf9377906MD52TEXTjosecoura_mariaconceicao_IOC_2010.pdf.txtjosecoura_mariaconceicao_IOC_2010.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Specific schistosomiasis treatment as a strategy for disease control
title Specific schistosomiasis treatment as a strategy for disease control
spellingShingle Specific schistosomiasis treatment as a strategy for disease control
Coura, José Rodrigues
Esquistossomose
Tratamento específico
Transmissão
Controle da morbidade
schistosomiasis
specific treatment
transmission
morbidity control
title_short Specific schistosomiasis treatment as a strategy for disease control
title_full Specific schistosomiasis treatment as a strategy for disease control
title_fullStr Specific schistosomiasis treatment as a strategy for disease control
title_full_unstemmed Specific schistosomiasis treatment as a strategy for disease control
title_sort Specific schistosomiasis treatment as a strategy for disease control
author Coura, José Rodrigues
author_facet Coura, José Rodrigues
Conceição, Maria José
author_role author
author2 Conceição, Maria José
author2_role author
dc.contributor.author.fl_str_mv Coura, José Rodrigues
Conceição, Maria José
dc.subject.other.pt_BR.fl_str_mv Esquistossomose
Tratamento específico
Transmissão
Controle da morbidade
topic Esquistossomose
Tratamento específico
Transmissão
Controle da morbidade
schistosomiasis
specific treatment
transmission
morbidity control
dc.subject.en.pt_BR.fl_str_mv schistosomiasis
specific treatment
transmission
morbidity control
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitáriasl. Rio de Janeiro, RJ. Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-11-29T13:34:54Z
dc.date.available.fl_str_mv 2018-11-29T13:34:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COURA, José Rodrigues; CONCEIÇÃO, Maria José. Specific schistosomiasis treatment as a strategy for disease control. Mem Inst Oswaldo Cruz, v.105, n.4, p.598-603, July 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30313
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv COURA, José Rodrigues; CONCEIÇÃO, Maria José. Specific schistosomiasis treatment as a strategy for disease control. Mem Inst Oswaldo Cruz, v.105, n.4, p.598-603, July 2010.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/30313
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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