Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46873 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. |
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Silveira, Melise ChavesSouza, Cláudio Marcos Rocha deSantos, Ivson Cassiano de OliveiraPontes, Leillane da SilvaOliveira, Thamirys Rachel Tavares eTeixeira, Camila Bastos TavaresCossatis, Nataly de AlmeidaPereira, Natacha FerreiraConceição Neto, Orlando Carlos daCosta, Bianca SantosRodrigues, Daiana Cristina SilvaAlbano, Rodolpho MattosSilva, Fabrício Alves Barbosa daMarques, Elizabeth AndradeLeão, Robson SouzaCarvalho-Assef, Ana Paula D'Alincourt da2021-04-23T19:47:04Z2021-04-23T19:47:04Z2021SILVEIRA, Melise Chaves et al. Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil. Frontiers in Medicine, v. 8, Article 635206, p. 1-8, Mar. 2021.2298-858Xhttps://www.arca.fiocruz.br/handle/icict/4687310.3389/fmed.2021.635206engFrontiers MediaResistência á multidrogasInfecções da corrente sanguíneaBacilos gram-negativosSequenciamento de genoma inteiroBrasilVigilânciaMultidrug-resistanceBloodstream infectionsGram-negative bacilliWhole-genome sequencingBrazilSurveillanceGenetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto de Alcântara Gomes. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Multidrug-resistant microorganisms are a well-known global problem, and gram-negative bacilli are top-ranking. When these pathogens are associated with bloodstream infections (BSI), outcomes become even worse. Here we applied whole-genome sequencing to access information about clonal distribution, resistance mechanism diversity and other molecular aspects of gram-negative bacilli (GNB) isolated from bloodstream infections in Brazil. It was possible to highlight international high-risk clones circulating in the Brazilian territory, such as CC258 for Klebsiella pneumoniae, ST79 for Acinetobacter baumannii and ST233 for Pseudomonas aeruginosa. Important associations can be made such as a negative correlation between CRISPR-Cas and K. pneumoniae CC258, while the genes blaTEM, blaKPC and blaCTX−M are highly associated with this clone. Specific relationships between A. baumannii clones and blaOXA−51 variants were also observed. All P. aeruginosa ST233 isolates showed the genes blaVIM and blaOXA486. In addition, some trends could be identified, where a new P. aeruginosa MDR clone (ST3079), a novel A. baumannii clonal profile circulating in Brazil (ST848), and important resistance associations in the form of blaVIM−2 and blaIMP−56 being found together in one ST233 strain, stand out. Such findings may help to develop approaches to deal with BSI and even other nosocomial infections caused by these important GNB.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46873/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMeliseCSilveira_AnaPaulaCAssef_etal_IOC_2021.pdfMeliseCSilveira_AnaPaulaCAssef_etal_IOC_2021.pdfapplication/pdf4291554https://www.arca.fiocruz.br/bitstream/icict/46873/2/MeliseCSilveira_AnaPaulaCAssef_etal_IOC_2021.pdf61eb782e293ce7f5427e81115c281738MD52TEXTMeliseCSilveira_AnaPaulaCAssef_etal_IOC_2021.pdf.txtMeliseCSilveira_AnaPaulaCAssef_etal_IOC_2021.pdf.txtExtracted texttext/plain45895https://www.arca.fiocruz.br/bitstream/icict/46873/3/MeliseCSilveira_AnaPaulaCAssef_etal_IOC_2021.pdf.txt3ce00f372f0e944918402edc29ac68a9MD53icict/468732023-09-05 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| dc.title.pt_BR.fl_str_mv |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| title |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| spellingShingle |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil Silveira, Melise Chaves Resistência á multidrogas Infecções da corrente sanguínea Bacilos gram-negativos Sequenciamento de genoma inteiro Brasil Vigilância Multidrug-resistance Bloodstream infections Gram-negative bacilli Whole-genome sequencing Brazil Surveillance |
| title_short |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| title_full |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| title_fullStr |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| title_full_unstemmed |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| title_sort |
Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil |
| author |
Silveira, Melise Chaves |
| author_facet |
Silveira, Melise Chaves Souza, Cláudio Marcos Rocha de Santos, Ivson Cassiano de Oliveira Pontes, Leillane da Silva Oliveira, Thamirys Rachel Tavares e Teixeira, Camila Bastos Tavares Cossatis, Nataly de Almeida Pereira, Natacha Ferreira Conceição Neto, Orlando Carlos da Costa, Bianca Santos Rodrigues, Daiana Cristina Silva Albano, Rodolpho Mattos Silva, Fabrício Alves Barbosa da Marques, Elizabeth Andrade Leão, Robson Souza Carvalho-Assef, Ana Paula D'Alincourt da |
| author_role |
author |
| author2 |
Souza, Cláudio Marcos Rocha de Santos, Ivson Cassiano de Oliveira Pontes, Leillane da Silva Oliveira, Thamirys Rachel Tavares e Teixeira, Camila Bastos Tavares Cossatis, Nataly de Almeida Pereira, Natacha Ferreira Conceição Neto, Orlando Carlos da Costa, Bianca Santos Rodrigues, Daiana Cristina Silva Albano, Rodolpho Mattos Silva, Fabrício Alves Barbosa da Marques, Elizabeth Andrade Leão, Robson Souza Carvalho-Assef, Ana Paula D'Alincourt da |
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author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silveira, Melise Chaves Souza, Cláudio Marcos Rocha de Santos, Ivson Cassiano de Oliveira Pontes, Leillane da Silva Oliveira, Thamirys Rachel Tavares e Teixeira, Camila Bastos Tavares Cossatis, Nataly de Almeida Pereira, Natacha Ferreira Conceição Neto, Orlando Carlos da Costa, Bianca Santos Rodrigues, Daiana Cristina Silva Albano, Rodolpho Mattos Silva, Fabrício Alves Barbosa da Marques, Elizabeth Andrade Leão, Robson Souza Carvalho-Assef, Ana Paula D'Alincourt da |
| dc.subject.other.pt_BR.fl_str_mv |
Resistência á multidrogas Infecções da corrente sanguínea Bacilos gram-negativos Sequenciamento de genoma inteiro Brasil Vigilância |
| topic |
Resistência á multidrogas Infecções da corrente sanguínea Bacilos gram-negativos Sequenciamento de genoma inteiro Brasil Vigilância Multidrug-resistance Bloodstream infections Gram-negative bacilli Whole-genome sequencing Brazil Surveillance |
| dc.subject.en.pt_BR.fl_str_mv |
Multidrug-resistance Bloodstream infections Gram-negative bacilli Whole-genome sequencing Brazil Surveillance |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-04-23T19:47:04Z |
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2021-04-23T19:47:04Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SILVEIRA, Melise Chaves et al. Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil. Frontiers in Medicine, v. 8, Article 635206, p. 1-8, Mar. 2021. |
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https://www.arca.fiocruz.br/handle/icict/46873 |
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2298-858X |
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10.3389/fmed.2021.635206 |
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SILVEIRA, Melise Chaves et al. Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil. Frontiers in Medicine, v. 8, Article 635206, p. 1-8, Mar. 2021. 2298-858X 10.3389/fmed.2021.635206 |
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