Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii

Detalhes bibliográficos
Autor(a) principal: Carvalho, Karyne Rangel
Data de Publicação: 2011
Outros Autores: Carvalho-Assef, Ana Paula D' A., Santos, Lia Galvão dos, Pereira, Maria José Félix, Asensi, Marise Dutra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30045
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
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spelling Carvalho, Karyne RangelCarvalho-Assef, Ana Paula D' A.Santos, Lia Galvão dosPereira, Maria José FélixAsensi, Marise Dutra2018-11-15T15:30:16Z2018-11-15T15:30:16Z2011CARVALHO, Karyne Rangel; et al. Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii. Mem Inst Oswaldo Cruz, v.106, n.4, p.505-506, June 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/300451678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Acinetobacter baumannii - blaOXA-23Imipenemimipenem-susceptibleAcinetobacter baumannii - blaOXA-23Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumanniiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.Hospital Federal de Bonsucesso. Rio de Janeiro, RJ, Brasil.Rede Labs D’Or. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.The aim of the current study was to describe the occurrence of the blaOXA-23 gene and the ISAba1 element in imipenem-susceptible Acinetobacter baumannii strains. By performing the polymerase chain reaction mapping using combinations of ISAba1 forward primers and the blaOXA-23-like gene reverse primers, we demonstrated that the ISAba1 element did not occur upstream of the blaOXA-23 gene in five of 31 isolates, which explained the lack of resistance to imipenem despite the presence of the blaOXA-23 gene. All of the blaOXA-23-positive isolates were susceptible to imipenem and meropenem with minimal inhibitory concentration ≤ 4 μg/mL. Pulsed-field gel electrophoresis analysis revealed four genotypes among the five blaOXA-23-positive isolates. The current report of the blaOXA-23 gene in imipenem-susceptible isolates provided evidence that this gene may be silently spread in a hospital environment and highlighted the threat of undetected reservoirs of carbapenemase genes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30045/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALkarineR_carvalho_etal_IOC_2011.pdfkarineR_carvalho_etal_IOC_2011.pdfapplication/pdf304883https://www.arca.fiocruz.br/bitstream/icict/30045/2/karineR_carvalho_etal_IOC_2011.pdf073e0a281341b649bd324994fd82df62MD52TEXTkarineR_carvalho_etal_IOC_2011.pdf.txtkarineR_carvalho_etal_IOC_2011.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
title Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
spellingShingle Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
Carvalho, Karyne Rangel
Acinetobacter baumannii - blaOXA-23
Imipenem
imipenem-susceptible
Acinetobacter baumannii - blaOXA-23
title_short Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
title_full Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
title_fullStr Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
title_full_unstemmed Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
title_sort Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii
author Carvalho, Karyne Rangel
author_facet Carvalho, Karyne Rangel
Carvalho-Assef, Ana Paula D' A.
Santos, Lia Galvão dos
Pereira, Maria José Félix
Asensi, Marise Dutra
author_role author
author2 Carvalho-Assef, Ana Paula D' A.
Santos, Lia Galvão dos
Pereira, Maria José Félix
Asensi, Marise Dutra
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Karyne Rangel
Carvalho-Assef, Ana Paula D' A.
Santos, Lia Galvão dos
Pereira, Maria José Félix
Asensi, Marise Dutra
dc.subject.other.pt_BR.fl_str_mv Acinetobacter baumannii - blaOXA-23
Imipenem
topic Acinetobacter baumannii - blaOXA-23
Imipenem
imipenem-susceptible
Acinetobacter baumannii - blaOXA-23
dc.subject.en.pt_BR.fl_str_mv imipenem-susceptible
Acinetobacter baumannii - blaOXA-23
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2018-11-15T15:30:16Z
dc.date.available.fl_str_mv 2018-11-15T15:30:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Karyne Rangel; et al. Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii. Mem Inst Oswaldo Cruz, v.106, n.4, p.505-506, June 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30045
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CARVALHO, Karyne Rangel; et al. Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii. Mem Inst Oswaldo Cruz, v.106, n.4, p.505-506, June 2011.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/30045
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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