The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29112 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany / Universidade Federal do Rio de Janeiro. Instituto Biomédico. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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Albuquerque, Cassiano Felippe Gonçalves deRohwedder, InaSilva, Adriana RibeiroFerreira, Alessandra SilveiraKurz, Angela R. M.Cougoule, CélineKlapproth, SarahEggersmann, TanjaSilva, Johnatas D.Oliveira, Gisele Pena DECapelozzi, Vera LuizaSchlesinger, Gabriel GutfilenCosta, Edlaine RijoMarins, Rita de Cassia Elias EstrelaMócsai, AttilaMaridonneau-Parini, IsabelleWalzog, BarbaraRocco, Patricia Rieken MacedoSperandio, MarkusFaria Neto, Hugo Caire de Castro2018-09-27T16:11:57Z2018-09-27T16:11:57Z2018ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. The Yin and Yang of Tyrosine Kinase inhibition During experimental Polymicrobial sepsis. Frontiers in Immunology, v.9, Article 901, 16p, Apr. 2018.1664-3224https://www.arca.fiocruz.br/handle/icict/2911210.3389/fimmu.2018.00901engFrontiers MediaSepseInflamaçãotráfico de leucócitosTirosina QuinasesSepse Polimicrobiana ExperimentalsepsosinflammationdesatinibSrc tyrosine kinaseleukocyte traffickingExperimental Polymicrobial SepsisThe Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany / Universidade Federal do Rio de Janeiro. Instituto Biomédico. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany.Université de Toulouse. Institut de Pharmacologie et de Biologie Structurale. Toulouse, France.Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany.Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo,. Faculdade de Medicina. Laboratório de Genômica Pulmonar. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Farmacologia. Rio de Janeiro, RJ, Brasil.Université de Toulouse. Institut de Pharmacologie et de Biologie Structurale. Toulouse, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Semmelweis University. Department of Physiology. MTA-SE “Lendület” Inflammation Physiology Research Group. Budapest, Hungry.Université de Toulouse. Institut de Pharmacologie et de Biologie Structurale. Toulouse, France.Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany.niversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Neutrophils are the first cells of our immune system to arrive at the site of inflammation. They release cytokines, e.g., chemokines, to attract further immune cells, but also actively start to phagocytose and kill pathogens. In the case of sepsis, this tightly regulated host defense mechanism can become uncontrolled and hyperactive resulting in severe organ damage. Currently, no effective therapy is available to fight sepsis; therefore, novel treatment targets that could prevent excessive inflammatory responses are warranted. Src Family tyrosine Kinases (SFK), a group of tyrosine kinases, have been shown to play a major role in regulating immune cell recruitment and host defense. Leukocytes with SFK depletion display severe spreading and migration defects along with reduced cytokine production. Thus, we investigated the effects of dasatinib, a tyrosine kinase inhibitor, with a strong inhibitory capacity on SFKs during sterile inflammation and polymicrobial sepsis in mice. We found that dasatinib-treated mice displayed diminished leukocyte adhesion and extravasation in tumor necrosis factor-α-stimulated cremaster muscle venules in vivo. In polymicrobial sepsis, sepsis severity, organ damage, and clinical outcome improved in a dose-dependent fashion pointing toward an optimal therapeutic window for dasatinib dosage during polymicrobial sepsis. Dasatinib treatment may, therefore, provide a balanced immune response by preventing an overshooting inflammatory reaction on the one side and bacterial overgrowth on the other side.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29112/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcassiano_albuquerque_etal_IOC_2018.pdfcassiano_albuquerque_etal_IOC_2018.pdfapplication/pdf6834616https://www.arca.fiocruz.br/bitstream/icict/29112/2/cassiano_albuquerque_etal_IOC_2018.pdf8e1a991aa16adc695b2c95abbce421bdMD52TEXTcassiano_albuquerque_etal_IOC_2018.pdf.txtcassiano_albuquerque_etal_IOC_2018.pdf.txtExtracted texttext/plain74411https://www.arca.fiocruz.br/bitstream/icict/29112/3/cassiano_albuquerque_etal_IOC_2018.pdf.txtbde7a2eba236e75f05785ac1e23a653aMD53icict/291122018-09-28 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| dc.title.pt_BR.fl_str_mv |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| title |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| spellingShingle |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis Albuquerque, Cassiano Felippe Gonçalves de Sepse Inflamação tráfico de leucócitos Tirosina Quinases Sepse Polimicrobiana Experimental sepsos inflammation desatinib Src tyrosine kinase leukocyte trafficking Experimental Polymicrobial Sepsis |
| title_short |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| title_full |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| title_fullStr |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| title_full_unstemmed |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| title_sort |
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |
| author |
Albuquerque, Cassiano Felippe Gonçalves de |
| author_facet |
Albuquerque, Cassiano Felippe Gonçalves de Rohwedder, Ina Silva, Adriana Ribeiro Ferreira, Alessandra Silveira Kurz, Angela R. M. Cougoule, Céline Klapproth, Sarah Eggersmann, Tanja Silva, Johnatas D. Oliveira, Gisele Pena DE Capelozzi, Vera Luiza Schlesinger, Gabriel Gutfilen Costa, Edlaine Rijo Marins, Rita de Cassia Elias Estrela Mócsai, Attila Maridonneau-Parini, Isabelle Walzog, Barbara Rocco, Patricia Rieken Macedo Sperandio, Markus Faria Neto, Hugo Caire de Castro |
| author_role |
author |
| author2 |
Rohwedder, Ina Silva, Adriana Ribeiro Ferreira, Alessandra Silveira Kurz, Angela R. M. Cougoule, Céline Klapproth, Sarah Eggersmann, Tanja Silva, Johnatas D. Oliveira, Gisele Pena DE Capelozzi, Vera Luiza Schlesinger, Gabriel Gutfilen Costa, Edlaine Rijo Marins, Rita de Cassia Elias Estrela Mócsai, Attila Maridonneau-Parini, Isabelle Walzog, Barbara Rocco, Patricia Rieken Macedo Sperandio, Markus Faria Neto, Hugo Caire de Castro |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Albuquerque, Cassiano Felippe Gonçalves de Rohwedder, Ina Silva, Adriana Ribeiro Ferreira, Alessandra Silveira Kurz, Angela R. M. Cougoule, Céline Klapproth, Sarah Eggersmann, Tanja Silva, Johnatas D. Oliveira, Gisele Pena DE Capelozzi, Vera Luiza Schlesinger, Gabriel Gutfilen Costa, Edlaine Rijo Marins, Rita de Cassia Elias Estrela Mócsai, Attila Maridonneau-Parini, Isabelle Walzog, Barbara Rocco, Patricia Rieken Macedo Sperandio, Markus Faria Neto, Hugo Caire de Castro |
| dc.subject.other.pt_BR.fl_str_mv |
Sepse Inflamação tráfico de leucócitos Tirosina Quinases Sepse Polimicrobiana Experimental |
| topic |
Sepse Inflamação tráfico de leucócitos Tirosina Quinases Sepse Polimicrobiana Experimental sepsos inflammation desatinib Src tyrosine kinase leukocyte trafficking Experimental Polymicrobial Sepsis |
| dc.subject.en.pt_BR.fl_str_mv |
sepsos inflammation desatinib Src tyrosine kinase leukocyte trafficking Experimental Polymicrobial Sepsis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Ludwig Maximilians University München. Walter Brendel Centre. Department of Cardiovascular Physiology and Pathophysiology. Klinikum der Universität. Munich, Germany / Universidade Federal do Rio de Janeiro. Instituto Biomédico. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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2018 |
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2018-09-27T16:11:57Z |
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2018-09-27T16:11:57Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. The Yin and Yang of Tyrosine Kinase inhibition During experimental Polymicrobial sepsis. Frontiers in Immunology, v.9, Article 901, 16p, Apr. 2018. |
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https://www.arca.fiocruz.br/handle/icict/29112 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2018.00901 |
| identifier_str_mv |
ALBUQUERQUE, Cassiano Felippe Gonçalves de; et al. The Yin and Yang of Tyrosine Kinase inhibition During experimental Polymicrobial sepsis. Frontiers in Immunology, v.9, Article 901, 16p, Apr. 2018. 1664-3224 10.3389/fimmu.2018.00901 |
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Frontiers Media |
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Frontiers Media |
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