Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18808 |
Resumo: | Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós-graduação em Biologia das Interações. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. |
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Pinto, Ana Maria VianaLeite, José Paulo G.Ferreira, Wilton J.Cavalcanti, Diana N.Villaça, Roberto C.Giongo, VivecaTeixeira, Valéria L.Paixão, Izabel Christina Nunes de Palmer2017-05-11T11:37:35Z2017-05-11T11:37:35Z2012PINTO, Ana Maria Viana; et al. Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus. Revista Brasileira de Farmacognosia, v.22, n.4, p.813-817, Jul. / Aug. 2012.0102-695Xhttps://www.arca.fiocruz.br/handle/icict/1880810.1590/S0102-695X2012005000060engSociedade Brasileira de FarmacognosiaVírus da diarreia viral bovinaMedicamentos antiviraisProdutos naturaisAlgas marinhasNatural productsantiviral drugsBovine viral diarrhea virusSeaweedMarine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Programa de Pós-graduação em Biologia das Interações. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Programa de Pós-Graduação em Química. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Laboratório de Produtos Naturais de Águas Marinhas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Laboratório de Produtos Naturais de Águas Marinhas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Programa de Pós-Graduação em Química. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Laboratório de Produtos Naturais de Águas Marinhas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós-graduação em Biologia das Interações. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Bovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the world. The purpose of this study was to evaluate the in vitro cytotoxic effect and antiviral properties of several marine natural products obtained from seaweeds: the indole alkaloid caulerpin (CAV, 1) and three diterpenes: 6-hydroxydichotoma- 3,14-diene-1,17-dial (DA, 2), 10,18-diacetoxy-8-hydroxy-2,6-dolabelladiene (DB1, 3) and 8,10,18-trihydroxy-2,6-dolabelladiene (DB3, 4). The screening to evaluate the cytotoxicity of compounds did not show toxic effects to MDBK cells. The antiviral activity of the compounds was measured by the inhibition of the cytopathic effect on infected cells by plaque assay (PA) and EC50 values were calculated for CAV (EC=2,0± 5.8), DA (EC 2,8± 7.7), DB1 (EC 2,0±9.7), and DB3 (EC 2,3±7.4). Acyclovir (EC50 322± 5.9) was used in all experiments as the control standard. Although the results of the antiviral activity suggest that all compounds are promising as antiviral agents against BVDV, the Selectivity Index suggests that DB1 is the safest of the compounds tested.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18808/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjosepaulo_leite_etal_IOC_2012.pdfjosepaulo_leite_etal_IOC_2012.pdfapplication/pdf886048https://www.arca.fiocruz.br/bitstream/icict/18808/2/josepaulo_leite_etal_IOC_2012.pdf2b972aaef30b9b3466e4f4653b803cfeMD52TEXTjosepaulo_leite_etal_IOC_2012.pdf.txtjosepaulo_leite_etal_IOC_2012.pdf.txtExtracted texttext/plain18819https://www.arca.fiocruz.br/bitstream/icict/18808/3/josepaulo_leite_etal_IOC_2012.pdf.txt8a44c3a78b04befbb845f7391d608c73MD53icict/188082018-08-15 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| dc.title.pt_BR.fl_str_mv |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| title |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| spellingShingle |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus Pinto, Ana Maria Viana Vírus da diarreia viral bovina Medicamentos antivirais Produtos naturais Algas marinhas Natural products antiviral drugs Bovine viral diarrhea virus Seaweed |
| title_short |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| title_full |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| title_fullStr |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| title_full_unstemmed |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| title_sort |
Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus |
| author |
Pinto, Ana Maria Viana |
| author_facet |
Pinto, Ana Maria Viana Leite, José Paulo G. Ferreira, Wilton J. Cavalcanti, Diana N. Villaça, Roberto C. Giongo, Viveca Teixeira, Valéria L. Paixão, Izabel Christina Nunes de Palmer |
| author_role |
author |
| author2 |
Leite, José Paulo G. Ferreira, Wilton J. Cavalcanti, Diana N. Villaça, Roberto C. Giongo, Viveca Teixeira, Valéria L. Paixão, Izabel Christina Nunes de Palmer |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinto, Ana Maria Viana Leite, José Paulo G. Ferreira, Wilton J. Cavalcanti, Diana N. Villaça, Roberto C. Giongo, Viveca Teixeira, Valéria L. Paixão, Izabel Christina Nunes de Palmer |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da diarreia viral bovina Medicamentos antivirais Produtos naturais Algas marinhas |
| topic |
Vírus da diarreia viral bovina Medicamentos antivirais Produtos naturais Algas marinhas Natural products antiviral drugs Bovine viral diarrhea virus Seaweed |
| dc.subject.en.pt_BR.fl_str_mv |
Natural products antiviral drugs Bovine viral diarrhea virus Seaweed |
| description |
Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós-graduação em Biologia das Interações. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. |
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2012 |
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2012 |
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2017-05-11T11:37:35Z |
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2017-05-11T11:37:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PINTO, Ana Maria Viana; et al. Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus. Revista Brasileira de Farmacognosia, v.22, n.4, p.813-817, Jul. / Aug. 2012. |
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https://www.arca.fiocruz.br/handle/icict/18808 |
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0102-695X |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0102-695X2012005000060 |
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PINTO, Ana Maria Viana; et al. Marine natural seaweed products as potential antiviral drugs against Bovine viral diarrhea virus. Revista Brasileira de Farmacognosia, v.22, n.4, p.813-817, Jul. / Aug. 2012. 0102-695X 10.1590/S0102-695X2012005000060 |
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Sociedade Brasileira de Farmacognosia |
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Sociedade Brasileira de Farmacognosia |
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