Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Lizcano, Omaira Vera
Data de Publicação: 2014
Outros Autores: Resende, Sarah Stela, Melo, Yonne Francis Chehuan, Lacerda, Marcus Vinicius Guimarães de, Brito, Cristiana Ferreira Alves de, Zalis, Mariano Gustavo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0074-0276140241
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10133
Resumo: CAPES, FAPEAM, CNPq
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spelling Lizcano, Omaira VeraResende, Sarah StelaMelo, Yonne Francis ChehuanLacerda, Marcus Vinicius Guimarães deBrito, Cristiana Ferreira Alves deZalis, Mariano Gustavo2015-04-28T16:54:53Z2015-04-28T16:54:53Z2014LIZCANO, Omaira Vera et al. Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 109, n. 7, p. 948-951, 20140074-0276https://www.arca.fiocruz.br/handle/icict/1013310.1590/0074-0276140241CAPES, FAPEAM, CNPqUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Patologia Clínica. Laboratório de Infectologia e Parasitologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrasilFundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, BrasilFundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrasilUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Patologia Clínica. Laboratório de Infectologia e Parasitologia Molecular. Rio de Janeiro, RJ, BrasilThe molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the mo¬lecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax iso¬lates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.engFundação Oswaldo CruzGenetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePlasmodium vivaxchloroquineresistanceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10133/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINAL2014_183.pdf2014_183.pdfapplication/pdf167247https://www.arca.fiocruz.br/bitstream/icict/10133/2/2014_183.pdf463b53e9fb9bb4fff895feb32cde5e77MD52TEXT2014_183.pdf.txt2014_183.pdf.txtExtracted texttext/plain67635https://www.arca.fiocruz.br/bitstream/icict/10133/3/2014_183.pdf.txtf533efa54794e0555ccc80c0bc9e3de2MD53icict/101332019-06-19 10:12:04.293oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:12:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
spellingShingle Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Lizcano, Omaira Vera
Plasmodium vivax
chloroquine
resistance
title_short Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_full Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_fullStr Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_full_unstemmed Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_sort Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
author Lizcano, Omaira Vera
author_facet Lizcano, Omaira Vera
Resende, Sarah Stela
Melo, Yonne Francis Chehuan
Lacerda, Marcus Vinicius Guimarães de
Brito, Cristiana Ferreira Alves de
Zalis, Mariano Gustavo
author_role author
author2 Resende, Sarah Stela
Melo, Yonne Francis Chehuan
Lacerda, Marcus Vinicius Guimarães de
Brito, Cristiana Ferreira Alves de
Zalis, Mariano Gustavo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lizcano, Omaira Vera
Resende, Sarah Stela
Melo, Yonne Francis Chehuan
Lacerda, Marcus Vinicius Guimarães de
Brito, Cristiana Ferreira Alves de
Zalis, Mariano Gustavo
dc.subject.en.pt_BR.fl_str_mv Plasmodium vivax
chloroquine
resistance
topic Plasmodium vivax
chloroquine
resistance
description CAPES, FAPEAM, CNPq
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-28T16:54:53Z
dc.date.available.fl_str_mv 2015-04-28T16:54:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIZCANO, Omaira Vera et al. Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 109, n. 7, p. 948-951, 2014
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10133
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-0276140241
identifier_str_mv LIZCANO, Omaira Vera et al. Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 109, n. 7, p. 948-951, 2014
0074-0276
10.1590/0074-0276140241
url https://www.arca.fiocruz.br/handle/icict/10133
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
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