Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil

Detalhes bibliográficos
Autor(a) principal: Franch, Fernando Abad
Data de Publicação: 2016
Outros Autores: Zamora-Perea, Elvira, Luz, Sergio Luiz Bessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17776
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Triatomıneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.
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spelling Franch, Fernando AbadZamora-Perea, ElviraLuz, Sergio Luiz Bessa2017-02-09T17:15:17Z2017-02-09T17:15:17Z2016FRANCH, Fernando Abad; ZAMORA-PEREA, Elvira; LUZ, Sergio Luiz Bessa. Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil. PLoS Medicine v. 14, n. 1, p. 1-22, 2016.1549-1277https://www.arca.fiocruz.br/handle/icict/1777610.1371/journal.pmed.1002213engPublic Library of ScienceAedes aegyptiDengueAedes aegyptiDengue,ZikaChikungunyaMosquito controlMosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Triatomıneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.BACKGROUND: Mosquito-borne viruses threaten public health worldwide. When the ratio of competent vectors to susceptible humans is low enough, the virus's basic reproductive number (R0) falls below 1.0 (each case generating, on average, <1.0 additional case) and the infection fades out from the population. Conventional mosquito control tactics, however, seldom yield R0 < 1.0. A promising alternative uses mosquitoes to disseminate a potent growth-regulator larvicide, pyriproxyfen (PPF), to aquatic larval habitats; this kills most mosquito juveniles and substantially reduces adult mosquito emergence. We tested mosquito-disseminated PPF in Manacapuru, a 60,000-inhabitant city (~650 ha) in Amazonian Brazil. METHODS AND FINDINGS: We sampled juvenile mosquitoes monthly in 100 dwellings over four periods in February 2014-January 2016: 12 baseline months, 5 mo of citywide PPF dissemination, 3 mo of focal PPF dissemination around Aedes-infested dwellings, and 3 mo after dissemination ended. We caught 19,434 juvenile mosquitoes (66% Aedes albopictus, 28% Ae. aegypti) in 8,271 trap-months. Using generalized linear mixed models, we estimated intervention effects on juvenile catch and adult emergence while adjusting for dwelling-level clustering, unequal sampling effort, and weather-related confounders. Following PPF dissemination, Aedes juvenile catch decreased by 79%-92% and juvenile mortality increased from 2%-7% to 80%-90%. Mean adult Aedes emergence fell from 1,077 per month (range 653-1,635) at baseline to 50.4 per month during PPF dissemination (range 2-117). Female Aedes emergence dropped by 96%-98%, such that the number of females emerging per person decreased to 0.06 females per person-month (range 0.002-0.129). Deterministic models predict, under plausible biological-epidemiological scenarios, that the R0 of typical Aedes-borne viruses would fall from 3-45 at baseline to 0.004-0.06 during PPF dissemination. The main limitations of our study were that it was a before-after trial lacking truly independent replicates and that we did not measure mosquito-borne virus transmission empirically. CONCLUSIONS: Mosquito-disseminated PPF has potential to block mosquito-borne virus transmission citywide, even under adverse scenarios. Our results signal new avenues for mosquito-borne disease prevention, likely including the effective control of Aedes-borne dengue, Zika, and chikungunya epidemics. Cluster-randomized controlled trials will help determine whether mosquito-disseminated PPF can, as our findings suggest, develop into a major tool for improving global public health.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/17776/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Abad-Franch_Fernando_ Mosquito-Disseminated_CPqRR_2016.pdfve_Abad-Franch_Fernando_ Mosquito-Disseminated_CPqRR_2016.pdfapplication/pdf1648980https://www.arca.fiocruz.br/bitstream/icict/17776/2/ve_Abad-Franch_Fernando_%20Mosquito-Disseminated_CPqRR_2016.pdfb13639766784341dfa9e703b7ff6f91bMD52TEXTve_Abad-Franch_Fernando_ Mosquito-Disseminated_CPqRR_2016.pdf.txtve_Abad-Franch_Fernando_ Mosquito-Disseminated_CPqRR_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
title Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
spellingShingle Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
Franch, Fernando Abad
Aedes aegypti
Dengue
Aedes aegypti
Dengue,
Zika
Chikungunya
Mosquito control
title_short Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
title_full Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
title_fullStr Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
title_full_unstemmed Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
title_sort Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil
author Franch, Fernando Abad
author_facet Franch, Fernando Abad
Zamora-Perea, Elvira
Luz, Sergio Luiz Bessa
author_role author
author2 Zamora-Perea, Elvira
Luz, Sergio Luiz Bessa
author2_role author
author
dc.contributor.author.fl_str_mv Franch, Fernando Abad
Zamora-Perea, Elvira
Luz, Sergio Luiz Bessa
dc.subject.other.pt_BR.fl_str_mv Aedes aegypti
Dengue
topic Aedes aegypti
Dengue
Aedes aegypti
Dengue,
Zika
Chikungunya
Mosquito control
dc.subject.en.pt_BR.fl_str_mv Aedes aegypti
Dengue,
Zika
Chikungunya
Mosquito control
description Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Triatomıneos e Epidemiologia da Doença de Chagas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-09T17:15:17Z
dc.date.available.fl_str_mv 2017-02-09T17:15:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FRANCH, Fernando Abad; ZAMORA-PEREA, Elvira; LUZ, Sergio Luiz Bessa. Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil. PLoS Medicine v. 14, n. 1, p. 1-22, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17776
dc.identifier.issn.pt_BR.fl_str_mv 1549-1277
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pmed.1002213
identifier_str_mv FRANCH, Fernando Abad; ZAMORA-PEREA, Elvira; LUZ, Sergio Luiz Bessa. Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil. PLoS Medicine v. 14, n. 1, p. 1-22, 2016.
1549-1277
10.1371/journal.pmed.1002213
url https://www.arca.fiocruz.br/handle/icict/17776
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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