Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1099/jmm.0.000346 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/22909 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (483674/2010-9) and Fundação Oswaldo Cruz (PAPES 407551/2012-3). |
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Silva Junior, Jailton de AzevedoAnjos, Eder Silva dosCordeiro, Soraia MachadoSantos, Milena Soares dosEscobar, Eliane CLobo, Paulo RochaCarvalho, Maria da GloriaReis, Mitermayer Galvão dosReis, Joice NevesCampos, Leila Carvalho2017-10-23T19:38:34Z2017-10-23T19:38:34Z2016SILVA JUNIOR, J. A. et al. Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil. Journal of Medical Microbiology, v. 65, p. 1164–1170, 2016.0022-2615https://www.arca.fiocruz.br/handle/icict/2290910.1099/jmm.0.000346Conselho Nacional de Desenvolvimento Científico e Tecnológico (483674/2010-9) and Fundação Oswaldo Cruz (PAPES 407551/2012-3).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilRespiratory Diseases Branch. Centers for Disease Control and Prevention. Atlanta, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilIn 2010, the 10-valent pneumococcal conjugate vaccine (PCV10) was introduced into the Brazilian childhood vaccination programme. Concerns have been raised that non-vaccine serotypes could increase in prevalence and reduce the benefits of vaccination; therefore, we examined non-PCV10 isolates recovered from meningitis during pre- (January 2008-May 2010) and post-vaccine (June 2010-December 2012) periods. Surveillance for pneumococcal meningitis was established at the Reference Hospital of Infectious Diseases in Salvador, Brazil. Serotypes were determined by multiplex PCR and/or Quellung reaction. Antimicrobial susceptibility testing was conducted by E-test and broth microdilution. Genotyping used PFGE and multi-locus sequence typing. A total of 148 cases of meningitis were identified from January 2008 to December 2012, 77 (52 %) of which were due to non-PCV10 isolates, with 50 (52.1 %) from pre-vaccine and 27 (52 %) from post-vaccine periods. In the post-vaccine period, the non-PCV10 serotypes 12F (n=6; 22.2 %), 10A (n=3; 11.1 %), 15B (n=2; 7.4 %) and 18B (n=2; 7.4 %) were the most prevalent. Forty-three isolates (55.8 %) were non-susceptible to one or more antibiotics. Non-susceptibility to penicillin was observed among serotypes 19A (three isolates), 9N (one isolate) and 12F (one isolate). PFGE and multi-locus sequence typing results demonstrated a wide genetic diversity among the isolates. During the early period following PCV10 introduction, no obvious emergence of a particular serotype was evident among non-PCV10 strains. This study underscores the importance of monitoring any changes among non-PCV10 cases after the introduction of PCV10.engMicrobiology SocietyStreptococcus pneumoniaeVacinas pneumocócicasMeningite, pneumococoVariação genéticaSerotipagemAdolescenteAdultoBrasilStreptococcus pneumoniaePneumococcal VaccinesMeningitis, PneumococcalGenetic VariationSerotypingAdolescentAdultBrazilGenetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22909/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAzevedo J genetic profiles....pdfAzevedo J genetic 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| dc.title.pt_BR.fl_str_mv |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| title |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| spellingShingle |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil Silva Junior, Jailton de Azevedo Streptococcus pneumoniae Vacinas pneumocócicas Meningite, pneumococo Variação genética Serotipagem Adolescente Adulto Brasil Streptococcus pneumoniae Pneumococcal Vaccines Meningitis, Pneumococcal Genetic Variation Serotyping Adolescent Adult Brazil |
| title_short |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| title_full |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| title_fullStr |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| title_full_unstemmed |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| title_sort |
Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil |
| author |
Silva Junior, Jailton de Azevedo |
| author_facet |
Silva Junior, Jailton de Azevedo Anjos, Eder Silva dos Cordeiro, Soraia Machado Santos, Milena Soares dos Escobar, Eliane C Lobo, Paulo Rocha Carvalho, Maria da Gloria Reis, Mitermayer Galvão dos Reis, Joice Neves Campos, Leila Carvalho |
| author_role |
author |
| author2 |
Anjos, Eder Silva dos Cordeiro, Soraia Machado Santos, Milena Soares dos Escobar, Eliane C Lobo, Paulo Rocha Carvalho, Maria da Gloria Reis, Mitermayer Galvão dos Reis, Joice Neves Campos, Leila Carvalho |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva Junior, Jailton de Azevedo Anjos, Eder Silva dos Cordeiro, Soraia Machado Santos, Milena Soares dos Escobar, Eliane C Lobo, Paulo Rocha Carvalho, Maria da Gloria Reis, Mitermayer Galvão dos Reis, Joice Neves Campos, Leila Carvalho |
| dc.subject.other.pt_BR.fl_str_mv |
Streptococcus pneumoniae Vacinas pneumocócicas Meningite, pneumococo Variação genética Serotipagem Adolescente Adulto Brasil |
| topic |
Streptococcus pneumoniae Vacinas pneumocócicas Meningite, pneumococo Variação genética Serotipagem Adolescente Adulto Brasil Streptococcus pneumoniae Pneumococcal Vaccines Meningitis, Pneumococcal Genetic Variation Serotyping Adolescent Adult Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Streptococcus pneumoniae Pneumococcal Vaccines Meningitis, Pneumococcal Genetic Variation Serotyping Adolescent Adult Brazil |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (483674/2010-9) and Fundação Oswaldo Cruz (PAPES 407551/2012-3). |
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2016 |
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2016 |
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2017-10-23T19:38:34Z |
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2017-10-23T19:38:34Z |
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SILVA JUNIOR, J. A. et al. Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil. Journal of Medical Microbiology, v. 65, p. 1164–1170, 2016. |
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https://www.arca.fiocruz.br/handle/icict/22909 |
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0022-2615 |
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10.1099/jmm.0.000346 |
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SILVA JUNIOR, J. A. et al. Genetic profiles and antimicrobial resistance of Streptococcus pneumoniae non-PCV10 serotype isolates recovered from meningitis cases in Salvador, Brazil. Journal of Medical Microbiology, v. 65, p. 1164–1170, 2016. 0022-2615 10.1099/jmm.0.000346 |
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Microbiology Society |
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Microbiology Society |
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