Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition

Detalhes bibliográficos
Autor(a) principal: Avellar, Ana Carolina de Sena
Data de Publicação: 2022
Outros Autores: Oliveira, Mariana Naves, Caixeta, Felipe, Souza, Rafaela Cristina Vieira e, Carvalho, Andréa Teixeira de, Faria, Ana Maria Caetano, Silveira-Nunes, Gabriela, Faria, Elaine Spezialli, Maioli, Tatiani Uceli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56300
Resumo: Universidade Federal de Minas Gerais. Departamento de Nutrição. Programa de Pós-graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil
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spelling Avellar, Ana Carolina de SenaOliveira, Mariana NavesCaixeta, FelipeSouza, Rafaela Cristina Vieira eCarvalho, Andréa Teixeira deFaria, Ana Maria CaetanoSilveira-Nunes, GabrielaFaria, Elaine SpezialliMaioli, Tatiani Uceli2023-01-03T18:59:40Z2023-01-03T18:59:40Z2022AVELLAR,Ana Carolina de Sena. Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition. Front Immunol., v. 13, 910807, 2022. doi: 10.3389/fimmu.2022.9108071664-3224https://www.arca.fiocruz.br/handle/icict/56300engFrontiers Research FoundationGestational Diabetes Mellitus Changes Human Colostrum Immune Compositioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Nutrição. Programa de Pós-graduação em Nutrição e Saúde. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Nutrição. Programa de Pós-graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil/Hospital Sofia Feldman. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Programa Interunidades de Pós-Graduação em Bioinformática. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Nutrição. Programa de Pós-graduação em Nutrição e Saúde. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Juiz de Fora. Juiz de Fora, MG, BrazilFundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Nutrição. Programa de Pós-graduação em Nutrição e Saúde. Belo Horizonte, MG, BrazilBreast milk is considered a complete food for babies. Up to 7 days postpartum, it is known as colostrum, rich in immunological compounds, responsible for providing nutrition and ensuring immune protection. However, some maternal factors, such as gestational diabetes mellitus (GDM), can change the concentration of bioactive compounds present in the colostrum and may affect the development of the newborn’s immune system. The effect of GDM on colostrum cytokine, chemokine, and growth factors is not well described. Thus, the present study evaluated whether the occurrence of GDM changes the concentration of biomarkers in the colostrum. A cross-sectional study was carried out on postpartum women who had healthy pregnancies and women who had been diagnosed with GDM. A sample of colostrum was collected for Luminex analysis. Our results showed that GDM mothers had higher secretion of cytokines and chemokines in the colostrum, with a higher concentration of IFN-g, IL-6, and IL-15, and a lower concentration of IL-1ra. Among growth factors, we identified a decreased concentration of GM-CSF in the colostrum of GDM mothers. Thus, the data obtained support the idea that the disease leads to immune alterations in the colostrum.gestational diabetes mellituscolostrumimmune systemcytokineschemokinesgrowth factorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56300/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGestational Diabetes Mellitus Changes .pdfGestational Diabetes Mellitus Changes .pdfapplication/pdf4746227https://www.arca.fiocruz.br/bitstream/icict/56300/2/Gestational%20Diabetes%20Mellitus%20Changes%20.pdfb29024524335b3116959ed9c8770a214MD52icict/563002023-01-03 15:59:41.878oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-01-03T18:59:41Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
title Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
spellingShingle Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
Avellar, Ana Carolina de Sena
gestational diabetes mellitus
colostrum
immune system
cytokines
chemokines
growth factors
title_short Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
title_full Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
title_fullStr Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
title_full_unstemmed Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
title_sort Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
author Avellar, Ana Carolina de Sena
author_facet Avellar, Ana Carolina de Sena
Oliveira, Mariana Naves
Caixeta, Felipe
Souza, Rafaela Cristina Vieira e
Carvalho, Andréa Teixeira de
Faria, Ana Maria Caetano
Silveira-Nunes, Gabriela
Faria, Elaine Spezialli
Maioli, Tatiani Uceli
author_role author
author2 Oliveira, Mariana Naves
Caixeta, Felipe
Souza, Rafaela Cristina Vieira e
Carvalho, Andréa Teixeira de
Faria, Ana Maria Caetano
Silveira-Nunes, Gabriela
Faria, Elaine Spezialli
Maioli, Tatiani Uceli
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Avellar, Ana Carolina de Sena
Oliveira, Mariana Naves
Caixeta, Felipe
Souza, Rafaela Cristina Vieira e
Carvalho, Andréa Teixeira de
Faria, Ana Maria Caetano
Silveira-Nunes, Gabriela
Faria, Elaine Spezialli
Maioli, Tatiani Uceli
dc.subject.en.en_US.fl_str_mv gestational diabetes mellitus
colostrum
immune system
cytokines
chemokines
growth factors
topic gestational diabetes mellitus
colostrum
immune system
cytokines
chemokines
growth factors
description Universidade Federal de Minas Gerais. Departamento de Nutrição. Programa de Pós-graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-03T18:59:40Z
dc.date.available.fl_str_mv 2023-01-03T18:59:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AVELLAR,Ana Carolina de Sena. Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition. Front Immunol., v. 13, 910807, 2022. doi: 10.3389/fimmu.2022.910807
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56300
dc.identifier.issn.en_US.fl_str_mv 1664-3224
identifier_str_mv AVELLAR,Ana Carolina de Sena. Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition. Front Immunol., v. 13, 910807, 2022. doi: 10.3389/fimmu.2022.910807
1664-3224
url https://www.arca.fiocruz.br/handle/icict/56300
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56300/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56300/2/Gestational%20Diabetes%20Mellitus%20Changes%20.pdf
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MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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