Immune outcomes of Zika virus infection in nonhuman primates

Detalhes bibliográficos
Autor(a) principal: Schouest, Blake
Data de Publicação: 2020
Outros Autores: Fahlberg, Marissa, Scheef, Elizabeth A., Ward, Matthew J., Headrick, Kyra, Szeltner, Dawn M., Blair, Robert V., Gilbert, Margaret H., Doyle‑Meyers, Lara A., Danner, Victoria W., Bonaldo, Myrna C., Wesson, Dawn M., Panganiban, Antonito T., Maness, Nicholas J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1038/s41598-020-69978-w
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47748
Resumo: Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA / Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
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spelling Schouest, BlakeFahlberg, MarissaScheef, Elizabeth A.Ward, Matthew J.Headrick, KyraSzeltner, Dawn M.Blair, Robert V.Gilbert, Margaret H.Doyle‑Meyers, Lara A.Danner, Victoria W.Bonaldo, Myrna C.Wesson, Dawn M.Panganiban, Antonito T.Maness, Nicholas J.2021-06-17T15:06:42Z2021-06-17T15:06:42Z2020SCHOUEST, Blake et al. Immune outcomes of Zika virus infection in nonhuman primates. Scientific Reports, v. 10, 13069, p. 1-12, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4774810.1038/s41598-020-69978-wengNature ResearchVírus da ZikaResultados imunesInfecçãoPrimatas não humanosZika virusInfectionNonhuman primatesImmune outcomesImmune outcomes of Zika virus infection in nonhuman primatesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBiomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA / Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.Division of Immunology, Tulane National Primate Research Center, Covington, LA, USA.Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA.Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA.Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA / Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA / Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.Although the Zika virus (ZIKV) epidemic is subsiding, immune responses that are important for controlling acute infection have not been defnitively characterized. Nonhuman primate (NHP) models were rapidly developed to understand the disease and to test vaccines, and these models have since provided an understanding of the immune responses that correlate with protection during natural infection and vaccination. Here, we infected a small group of male rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques with a minimally passaged Brazilian ZIKV isolate and used multicolor fow cytometry and transcriptional profling to describe early immune patterns following infection. We found evidence of strong innate antiviral responses together with induction of neutralizing antibodies and T cell responses. We also assessed the relative importance of CD8 T cells in controlling infection by carrying out CD8 T cell depletion in an additional two animals of each species. CD8 depletion appeared to dysregulate early antiviral responses and possibly increase viral persistence, but the absence of CD8 T cells ultimately did not impair control of the virus. Together, these data describe immunological trends in two NHP species during acute ZIKV infection, providing an account of early responses that may be important in controlling infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47748/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMirnaC_Bonaldo_etal_IOC_2020.pdfMirnaC_Bonaldo_etal_IOC_2020.pdfapplication/pdf1841994https://www.arca.fiocruz.br/bitstream/icict/47748/2/MirnaC_Bonaldo_etal_IOC_2020.pdf22460bbce5be4205d6a3432ad25d1dfbMD52TEXTMirnaC_Bonaldo_etal_IOC_2020.pdf.txtMirnaC_Bonaldo_etal_IOC_2020.pdf.txtExtracted texttext/plain56803https://www.arca.fiocruz.br/bitstream/icict/47748/3/MirnaC_Bonaldo_etal_IOC_2020.pdf.txt39dfc601a72f6f09ed1e401e4060e0a2MD53icict/477482022-05-14 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dc.title.pt_BR.fl_str_mv Immune outcomes of Zika virus infection in nonhuman primates
title Immune outcomes of Zika virus infection in nonhuman primates
spellingShingle Immune outcomes of Zika virus infection in nonhuman primates
Schouest, Blake
Vírus da Zika
Resultados imunes
Infecção
Primatas não humanos
Zika virus
Infection
Nonhuman primates
Immune outcomes
title_short Immune outcomes of Zika virus infection in nonhuman primates
title_full Immune outcomes of Zika virus infection in nonhuman primates
title_fullStr Immune outcomes of Zika virus infection in nonhuman primates
title_full_unstemmed Immune outcomes of Zika virus infection in nonhuman primates
title_sort Immune outcomes of Zika virus infection in nonhuman primates
author Schouest, Blake
author_facet Schouest, Blake
Fahlberg, Marissa
Scheef, Elizabeth A.
Ward, Matthew J.
Headrick, Kyra
Szeltner, Dawn M.
Blair, Robert V.
Gilbert, Margaret H.
Doyle‑Meyers, Lara A.
Danner, Victoria W.
Bonaldo, Myrna C.
Wesson, Dawn M.
Panganiban, Antonito T.
Maness, Nicholas J.
author_role author
author2 Fahlberg, Marissa
Scheef, Elizabeth A.
Ward, Matthew J.
Headrick, Kyra
Szeltner, Dawn M.
Blair, Robert V.
Gilbert, Margaret H.
Doyle‑Meyers, Lara A.
Danner, Victoria W.
Bonaldo, Myrna C.
Wesson, Dawn M.
Panganiban, Antonito T.
Maness, Nicholas J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schouest, Blake
Fahlberg, Marissa
Scheef, Elizabeth A.
Ward, Matthew J.
Headrick, Kyra
Szeltner, Dawn M.
Blair, Robert V.
Gilbert, Margaret H.
Doyle‑Meyers, Lara A.
Danner, Victoria W.
Bonaldo, Myrna C.
Wesson, Dawn M.
Panganiban, Antonito T.
Maness, Nicholas J.
dc.subject.other.pt_BR.fl_str_mv Vírus da Zika
Resultados imunes
Infecção
Primatas não humanos
topic Vírus da Zika
Resultados imunes
Infecção
Primatas não humanos
Zika virus
Infection
Nonhuman primates
Immune outcomes
dc.subject.en.pt_BR.fl_str_mv Zika virus
Infection
Nonhuman primates
Immune outcomes
description Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA / Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-06-17T15:06:42Z
dc.date.available.fl_str_mv 2021-06-17T15:06:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHOUEST, Blake et al. Immune outcomes of Zika virus infection in nonhuman primates. Scientific Reports, v. 10, 13069, p. 1-12, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47748
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-020-69978-w
identifier_str_mv SCHOUEST, Blake et al. Immune outcomes of Zika virus infection in nonhuman primates. Scientific Reports, v. 10, 13069, p. 1-12, 2020.
2045-2322
10.1038/s41598-020-69978-w
url https://www.arca.fiocruz.br/handle/icict/47748
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/47748/1/license.txt
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