Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8384 |
Resumo: | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of America |
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Teixeira, Clarissa RomeroGomes, Regis Bernardo BrandimCollin, NicolasReynoso, DavidJochim, RyanOliveira, Luiz Fabiano BorgesSeitz, AmyElnaiem, Dia-Eldin ACaldas, Arlene de Jesus MendesSouza, Ana Paula Almeida deBrodskyn, Claudia IdaOliveira, Camila Indiani deMendonça, Ivete Lopes deCosta, Carlos Henrique NeryVolf, PetrBarral, Aldina Maria PradoKamhawi, ShadenValenzuela, Jesus G2014-09-16T12:11:13Z2014-09-16T12:11:13Z2010TEIXEIRA, C. et al. Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America. PLoS Neglected Tropical Diseases, v. 4, n. 3, p. e638, 2010.1935-2735https://www.arca.fiocruz.br/handle/icict/838410.1371/journal.pntd.0000638engPublic Library of ScienceDiscovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaUniversity of Maryland Eastern Shore. Department of Natural Sciences. Princess Anne. Maryland, United States of AmericaUniversidade Federal do Maranhão. São Luis, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Goncalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Goncalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Goncalo Moniz. Salvador, BA, BrasilUniversidade Federal do Piaui. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, BrasilUniversidade Federal do Piaui. Instituto de Doenças Tropicais Natan Portella. Laboratório de Leishmanioses. Teresina, PI, BrasilCharles University in Prague. Faculty of Science. Department of Parasitology. Prague, Czech RepublicFundação Oswaldo Cruz. Centro de Pesquisas Goncalo Moniz. Salvador, BA, BrasilNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of AmericaBACKGROUND: Sand flies deliver Leishmania parasites to a host alongside salivary molecules that affect infection outcomes. Though some proteins are immunogenic and have potential as markers of vector exposure, their identity and vector specificity remain elusive. METHODOLOGY/PRINCIPAL FINDINGS: We screened human, dog, and fox sera from endemic areas of visceral leishmaniasis to identify potential markers of specific exposure to saliva of Lutzomyia longipalpis. Human and dog sera were further tested against additional sand fly species. Recombinant proteins of nine transcripts encoding secreted salivary molecules of Lu. longipalpis were produced, purified, and tested for antigenicity and specificity. Use of recombinant proteins corresponding to immunogenic molecules in Lu. longipalpis saliva identified LJM17 and LJM11 as potential markers of exposure. LJM17 was recognized by human, dog, and fox sera; LJM11 by humans and dogs. Notably, LJM17 and LJM11 were specifically recognized by humans exposed to Lu. longipalpis but not by individuals exposed to Lu. intermedia. CONCLUSIONS/SIGNIFICANCE: Salivary recombinant proteins are of value as markers of vector exposure. In humans, LJM17 and LJM11 emerged as potential markers of specific exposure to Lu. longipalpis, the vector of Leishmania infantum chagasi in Latin America. In dogs, LJM17, LJM11, LJL13, LJL23, and LJL143 emerged as potential markers of sand fly exposure. Testing these recombinant proteins in large scale studies will validate their usefulness as specific markers of Lu. longipalpis exposure in humans and of sand fly exposure in dogs.Vetores de DoençasMordeduras e Picadas de Insetos/imunologiaProteínas de Insetos/imunologiaPsychodidae/imunologiaSaliva/imunologiaAnimaisAnticorpos/sangueCãesRaposasHumanosProteínas de Insetos/uso diagnósticoProteínas de Insetos/genéticaAmérica LatinaProteínas Recombinantes/uso diagnósticoProteínas Recombinantes/genéticaProteínas Recombinantes/imunologiaSensibilidade e Especificidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8384/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALTeixeira, C. Discovery of markers of......pdfTeixeira, C. 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dc.title.pt_BR.fl_str_mv |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
title |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
spellingShingle |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America Teixeira, Clarissa Romero Vetores de Doenças Mordeduras e Picadas de Insetos/imunologia Proteínas de Insetos/imunologia Psychodidae/imunologia Saliva/imunologia Animais Anticorpos/sangue Cães Raposas Humanos Proteínas de Insetos/uso diagnóstico Proteínas de Insetos/genética América Latina Proteínas Recombinantes/uso diagnóstico Proteínas Recombinantes/genética Proteínas Recombinantes/imunologia Sensibilidade e Especificidade |
title_short |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
title_full |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
title_fullStr |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
title_full_unstemmed |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
title_sort |
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America |
author |
Teixeira, Clarissa Romero |
author_facet |
Teixeira, Clarissa Romero Gomes, Regis Bernardo Brandim Collin, Nicolas Reynoso, David Jochim, Ryan Oliveira, Luiz Fabiano Borges Seitz, Amy Elnaiem, Dia-Eldin A Caldas, Arlene de Jesus Mendes Souza, Ana Paula Almeida de Brodskyn, Claudia Ida Oliveira, Camila Indiani de Mendonça, Ivete Lopes de Costa, Carlos Henrique Nery Volf, Petr Barral, Aldina Maria Prado Kamhawi, Shaden Valenzuela, Jesus G |
author_role |
author |
author2 |
Gomes, Regis Bernardo Brandim Collin, Nicolas Reynoso, David Jochim, Ryan Oliveira, Luiz Fabiano Borges Seitz, Amy Elnaiem, Dia-Eldin A Caldas, Arlene de Jesus Mendes Souza, Ana Paula Almeida de Brodskyn, Claudia Ida Oliveira, Camila Indiani de Mendonça, Ivete Lopes de Costa, Carlos Henrique Nery Volf, Petr Barral, Aldina Maria Prado Kamhawi, Shaden Valenzuela, Jesus G |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Clarissa Romero Gomes, Regis Bernardo Brandim Collin, Nicolas Reynoso, David Jochim, Ryan Oliveira, Luiz Fabiano Borges Seitz, Amy Elnaiem, Dia-Eldin A Caldas, Arlene de Jesus Mendes Souza, Ana Paula Almeida de Brodskyn, Claudia Ida Oliveira, Camila Indiani de Mendonça, Ivete Lopes de Costa, Carlos Henrique Nery Volf, Petr Barral, Aldina Maria Prado Kamhawi, Shaden Valenzuela, Jesus G |
dc.subject.decs.pt_BR.fl_str_mv |
Vetores de Doenças Mordeduras e Picadas de Insetos/imunologia Proteínas de Insetos/imunologia Psychodidae/imunologia Saliva/imunologia Animais Anticorpos/sangue Cães Raposas Humanos Proteínas de Insetos/uso diagnóstico Proteínas de Insetos/genética América Latina Proteínas Recombinantes/uso diagnóstico Proteínas Recombinantes/genética Proteínas Recombinantes/imunologia Sensibilidade e Especificidade |
topic |
Vetores de Doenças Mordeduras e Picadas de Insetos/imunologia Proteínas de Insetos/imunologia Psychodidae/imunologia Saliva/imunologia Animais Anticorpos/sangue Cães Raposas Humanos Proteínas de Insetos/uso diagnóstico Proteínas de Insetos/genética América Latina Proteínas Recombinantes/uso diagnóstico Proteínas Recombinantes/genética Proteínas Recombinantes/imunologia Sensibilidade e Especificidade |
description |
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Rockville, MD, United States of America |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2014-09-16T12:11:13Z |
dc.date.available.fl_str_mv |
2014-09-16T12:11:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
TEIXEIRA, C. et al. Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America. PLoS Neglected Tropical Diseases, v. 4, n. 3, p. e638, 2010. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8384 |
dc.identifier.issn.none.fl_str_mv |
1935-2735 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0000638 |
identifier_str_mv |
TEIXEIRA, C. et al. Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin America. PLoS Neglected Tropical Diseases, v. 4, n. 3, p. e638, 2010. 1935-2735 10.1371/journal.pntd.0000638 |
url |
https://www.arca.fiocruz.br/handle/icict/8384 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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