The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/21070 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Peixoto, Christina AlvesGomes, Fabiana Oliveira Dos Santos2017-09-19T17:48:40Z2017-09-19T17:48:40Z2015PEIXOTO, C. A.; GOMES, F. O. D. S. The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review. Journal of Inflammation (London, England), v. 12, p. 54, 2015.1476-9255https://www.arca.fiocruz.br/handle/icict/2107010.1186/s12950-015-0099-7porNucleotídeo Cíclico Fosfodiesterase do Tipo 5Hiperplasia ProstáticaSintomas do Trato Urinário InferiorCyclic Nucleotide Phosphodiesterases, Type 5Prostatic HyperplasiaLower Urinary Tract SymptomsThe role of phosphodiesterase-5 inhibitors in prostatic inflammation: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilClinical and basic experimental evidence indicates that chronic inflammation is the greatest factor in benign prostatic hyperplasia (BPH) progression, which is the most common cause of Lower Urinary Tract Symptoms (LUTS). The use of anti-inflammatory agents such as steroids, cyclooxygenase-2 (COX-2) and phytotherapics have been investigated as forms of treatment for various prostate diseases. Recent evidence has demonstrated that PDE5 inhibitors (PDE5Is) improve symptoms of BPH/LUTS, possibly as a result of the relaxing of the smooth muscle fibers of the bladder and prostate by NO/cGMPc signaling, or by improving RhoA/Rho-kinase (ROCK), and reduction of the hyperactivity of the autonomic nervous system. However, some results have suggested that besides vasodilatation and their anti-proliferative effect, PDE5Is exert a direct anti-inflammatory effect, by raising cGMP. Given that inflammation is major factor in benign prostatic hyperplasia (BPH) progression, PDE5Is could act also restore prostatic function as they act as potent anti-inflammatory drugs. This review aims to provide a comprehensive summary of the use of phosphodiesterase-5 inhibitors to treat prostatic inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/21070/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26379476 2015 pei-rol.oa.pdf26379476 2015 pei-rol.oa.pdfapplication/pdf540462https://www.arca.fiocruz.br/bitstream/icict/21070/2/26379476%202015%20pei-rol.oa.pdf427ab923c86657244de07494766fdccfMD52TEXT26379476 2015 pei-rol.oa.pdf.txt26379476 2015 pei-rol.oa.pdf.txtExtracted texttext/plain50774https://www.arca.fiocruz.br/bitstream/icict/21070/3/26379476%202015%20pei-rol.oa.pdf.txtc04bb549b8220f64fe116bab83f1c776MD53icict/210702018-08-15 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| dc.title.pt_BR.fl_str_mv |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| title |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| spellingShingle |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review Peixoto, Christina Alves Nucleotídeo Cíclico Fosfodiesterase do Tipo 5 Hiperplasia Prostática Sintomas do Trato Urinário Inferior Cyclic Nucleotide Phosphodiesterases, Type 5 Prostatic Hyperplasia Lower Urinary Tract Symptoms |
| title_short |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| title_full |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| title_fullStr |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| title_full_unstemmed |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| title_sort |
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review |
| author |
Peixoto, Christina Alves |
| author_facet |
Peixoto, Christina Alves Gomes, Fabiana Oliveira Dos Santos |
| author_role |
author |
| author2 |
Gomes, Fabiana Oliveira Dos Santos |
| author2_role |
author |
| dc.contributor.author.fl_str_mv |
Peixoto, Christina Alves Gomes, Fabiana Oliveira Dos Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Nucleotídeo Cíclico Fosfodiesterase do Tipo 5 Hiperplasia Prostática Sintomas do Trato Urinário Inferior |
| topic |
Nucleotídeo Cíclico Fosfodiesterase do Tipo 5 Hiperplasia Prostática Sintomas do Trato Urinário Inferior Cyclic Nucleotide Phosphodiesterases, Type 5 Prostatic Hyperplasia Lower Urinary Tract Symptoms |
| dc.subject.en.pt_BR.fl_str_mv |
Cyclic Nucleotide Phosphodiesterases, Type 5 Prostatic Hyperplasia Lower Urinary Tract Symptoms |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2015 |
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2015 |
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2017-09-19T17:48:40Z |
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2017-09-19T17:48:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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PEIXOTO, C. A.; GOMES, F. O. D. S. The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review. Journal of Inflammation (London, England), v. 12, p. 54, 2015. |
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https://www.arca.fiocruz.br/handle/icict/21070 |
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1476-9255 |
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10.1186/s12950-015-0099-7 |
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PEIXOTO, C. A.; GOMES, F. O. D. S. The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review. Journal of Inflammation (London, England), v. 12, p. 54, 2015. 1476-9255 10.1186/s12950-015-0099-7 |
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