Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Silva, Tânia Regina Marques da
Data de Publicação: 2010
Outros Autores: Petersen, Antonio Luis de Oliveira Almeida, Almeida, Taís Fontoura de, Freitas, Luiz Antonio Rodrigues de, Veras, Patrícia Sampaio Tavares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1764
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Silva, Tânia Regina Marques daPetersen, Antonio Luis de Oliveira AlmeidaAlmeida, Taís Fontoura deFreitas, Luiz Antonio Rodrigues deVeras, Patrícia Sampaio Tavares2011-03-27T00:54:04Z2011-03-27T00:54:04Z2010SILVA, T. R. M. da. et al. Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice. Memórias do Instituto Oswaldo Cruz, v.105, n.5, p. 642-648, 2010.20835610https://www.arca.fiocruz.br/handle/icict/1764engMycobacterium fortuitumMycobacterium intracellulareGranulomaFígadoControle da infeçãoGranuloma/PAFígado/IMInfecções Atípicas por Mycobacterium/PAMycobacterium avium/IMMycobacterium fortuitum/IMCamundongos Endogâmicos BALB CControl of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Mycobacterium fortuitum is a rapidly growing nontuberculous Mycobacterium that can cause a range of diseases in humans. Complications from M. fortuitum infection have been associated with numerous surgical procedures. A protective immune response against pathogenic mycobacterial infections is dependent on the granuloma formation. Within the granuloma, the macrophage effector response can inhibit bacterial replication and mediate the intracellular killing of bacteria. The granulomatous responses of BALB/c mice to rapidly and slowly growing mycobacteria were assessed in vivo and the bacterial loads in spleens and livers from M. fortuitum and Mycobacterium intracellulare-infected mice, as well as the number and size of granulomas in liver sections, were quantified. Bacterial loads were found to be approximately two times lower in M. fortuitum-infected mice than in M. intracellulareinfected mice and M. fortuitum-infected mice presented fewer granulomas compared to M. intracellulare-infected mice. These granulomas were characterized by the presence of Mac-1+ and CD4+ cells. Additionally, IFN-γ mRNA expression was higher in the livers of M. fortuitum-infected mice than in those of M. intracellulare-infected mice. These data clearly show that mice are more capable of controlling an infection with M. fortuitum than M. intracellulare. This capacity is likely related to distinct granuloma formations in mice infected with M. fortuitum but not with M. intracellulare.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1764/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALControl of Mycobacterium fortuitum and Mycobacterium.pdfControl of Mycobacterium fortuitum and Mycobacterium.pdfapplication/pdf1125093https://www.arca.fiocruz.br/bitstream/icict/1764/3/Control%20of%20Mycobacterium%20fortuitum%20and%20Mycobacterium.pdf47f7c796a5a7d12103e885cc72bd497aMD53TEXTControl of Mycobacterium fortuitum and Mycobacterium.pdf.txtControl of Mycobacterium fortuitum and Mycobacterium.pdf.txtExtracted texttext/plain40048https://www.arca.fiocruz.br/bitstream/icict/1764/6/Control%20of%20Mycobacterium%20fortuitum%20and%20Mycobacterium.pdf.txt707c7163884c4bea92e1e15ac4535094MD56THUMBNAILControl of Mycobacterium fortuitum and Mycobacterium.pdf.jpgControl of Mycobacterium fortuitum and Mycobacterium.pdf.jpgGenerated Thumbnailimage/jpeg2282https://www.arca.fiocruz.br/bitstream/icict/1764/5/Control%20of%20Mycobacterium%20fortuitum%20and%20Mycobacterium.pdf.jpg2b82386ad7b899b79b6b6a91cbb57c9eMD55icict/17642023-03-15 14:32:54.617oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
title Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
spellingShingle Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
Silva, Tânia Regina Marques da
Mycobacterium fortuitum
Mycobacterium intracellulare
Granuloma
Fígado
Controle da infeção
Granuloma/PA
Fígado/IM
Infecções Atípicas por Mycobacterium/PA
Mycobacterium avium/IM
Mycobacterium fortuitum/IM
Camundongos Endogâmicos BALB C
title_short Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
title_full Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
title_fullStr Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
title_full_unstemmed Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
title_sort Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
author Silva, Tânia Regina Marques da
author_facet Silva, Tânia Regina Marques da
Petersen, Antonio Luis de Oliveira Almeida
Almeida, Taís Fontoura de
Freitas, Luiz Antonio Rodrigues de
Veras, Patrícia Sampaio Tavares
author_role author
author2 Petersen, Antonio Luis de Oliveira Almeida
Almeida, Taís Fontoura de
Freitas, Luiz Antonio Rodrigues de
Veras, Patrícia Sampaio Tavares
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Tânia Regina Marques da
Petersen, Antonio Luis de Oliveira Almeida
Almeida, Taís Fontoura de
Freitas, Luiz Antonio Rodrigues de
Veras, Patrícia Sampaio Tavares
dc.subject.other.pt_BR.fl_str_mv Mycobacterium fortuitum
Mycobacterium intracellulare
Granuloma
Fígado
Controle da infeção
topic Mycobacterium fortuitum
Mycobacterium intracellulare
Granuloma
Fígado
Controle da infeção
Granuloma/PA
Fígado/IM
Infecções Atípicas por Mycobacterium/PA
Mycobacterium avium/IM
Mycobacterium fortuitum/IM
Camundongos Endogâmicos BALB C
dc.subject.decs.pt_BR.fl_str_mv Granuloma/PA
Fígado/IM
Infecções Atípicas por Mycobacterium/PA
Mycobacterium avium/IM
Mycobacterium fortuitum/IM
Camundongos Endogâmicos BALB C
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2011-03-27T00:54:04Z
dc.date.available.fl_str_mv 2011-03-27T00:54:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, T. R. M. da. et al. Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice. Memórias do Instituto Oswaldo Cruz, v.105, n.5, p. 642-648, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1764
dc.identifier.other.none.fl_str_mv 20835610
identifier_str_mv SILVA, T. R. M. da. et al. Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice. Memórias do Instituto Oswaldo Cruz, v.105, n.5, p. 642-648, 2010.
20835610
url https://www.arca.fiocruz.br/handle/icict/1764
dc.language.iso.fl_str_mv eng
language eng
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