Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up

Detalhes bibliográficos
Autor(a) principal: Girianelli, Vania Reis
Data de Publicação: 2016
Outros Autores: Thuler, Luiz Claudio Santos, Silva, Gulnar Azevedo e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32349
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Girianelli, Vania ReisThuler, Luiz Claudio SantosSilva, Gulnar Azevedo e2019-04-03T21:19:10Z2019-04-03T21:19:10Z2016GIRIANELLI, Vania Reis; THULER, Luiz Claudio Santos; SILVA, Gulnar Azevedo e. Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up. Revista Brasileira de Ginecologia e Obstetrícia, v. 38, n. 3, p. 147-153, 2016.0100-7203https://www.arca.fiocruz.br/handle/icict/3234910.1055/s-0036-15807120100-7203engThieme OpenPredictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-upinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Division of Clinical Research. Rio de Janeiro, RJ, Brazil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil.Purpose: To compare the predictive capability of HPV and Pap smear tests for screening pre-cancerous lesions of the cervix over a three-year follow-up, in a population of users of the Brazilian National Health System (SUS). Methods: This is a retrospective cohort study of 2,032 women with satisfactory results for Pap smear and HPV tests using second-generation hybrid capture, made in a previous study. We followed them for 36 months with data obtained from medical records, the Cervix Cancer Information System (SISCOLO), and the Mortality Information System (SIM). The outcome was a histological diagnosis of cervical intraepithelial neoplasia grade 2 or more advanced lesions (CIN2þ). We constructed progression curves of the baseline test results for the period, using the Kaplan-Meier method, and estimated sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratios for each test. Results: A total of 1,440 women had at least one test during follow-up. Progression curves of the baseline test results indicated differences in capability to detect CIN2þ (p < 0.001) with significantly greater capability when both tests were abnormal, followed by only a positive HPV test. The HPV test was more sensitive than the Pap smear (88.7% and 73.6%, respectively; p < 0.05) and had a better negative likelihood ratio (0.13 and 0.30, respectively). Specificity and positive likelihood ratio of the tests were similar. Conclusions: These findings corroborate the importance of HPV test as a primary cervical cancer screening.Uterine cervical neoplasmPrevention and controlMass screeningPapanicolaouHPVCohort studyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32349/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_ Girianelli _Vania_etal_INI_2016.pdfve_ Girianelli _Vania_etal_INI_2016.pdfapplication/pdf177999https://www.arca.fiocruz.br/bitstream/icict/32349/2/ve_%20Girianelli%20_Vania_etal_INI_2016.pdf2c6aa6251e69d9037bff1f24bd5226b9MD52TEXTve_ Girianelli _Vania_etal_INI_2016.pdf.txtve_ Girianelli _Vania_etal_INI_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
title Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
spellingShingle Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
Girianelli, Vania Reis
Uterine cervical neoplasm
Prevention and control
Mass screening
Papanicolaou
HPV
Cohort study
title_short Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
title_full Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
title_fullStr Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
title_full_unstemmed Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
title_sort Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up
author Girianelli, Vania Reis
author_facet Girianelli, Vania Reis
Thuler, Luiz Claudio Santos
Silva, Gulnar Azevedo e
author_role author
author2 Thuler, Luiz Claudio Santos
Silva, Gulnar Azevedo e
author2_role author
author
dc.contributor.author.fl_str_mv Girianelli, Vania Reis
Thuler, Luiz Claudio Santos
Silva, Gulnar Azevedo e
dc.subject.en.pt_BR.fl_str_mv Uterine cervical neoplasm
Prevention and control
Mass screening
Papanicolaou
HPV
Cohort study
topic Uterine cervical neoplasm
Prevention and control
Mass screening
Papanicolaou
HPV
Cohort study
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-03T21:19:10Z
dc.date.available.fl_str_mv 2019-04-03T21:19:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GIRIANELLI, Vania Reis; THULER, Luiz Claudio Santos; SILVA, Gulnar Azevedo e. Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up. Revista Brasileira de Ginecologia e Obstetrícia, v. 38, n. 3, p. 147-153, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32349
dc.identifier.issn.pt_BR.fl_str_mv 0100-7203
dc.identifier.doi.none.fl_str_mv 10.1055/s-0036-1580712
dc.identifier.eissn.none.fl_str_mv 0100-7203
identifier_str_mv GIRIANELLI, Vania Reis; THULER, Luiz Claudio Santos; SILVA, Gulnar Azevedo e. Predictive capability of HPV and pap tests in screening for cervical cancer over a three-year follow-up. Revista Brasileira de Ginecologia e Obstetrícia, v. 38, n. 3, p. 147-153, 2016.
0100-7203
10.1055/s-0036-1580712
url https://www.arca.fiocruz.br/handle/icict/32349
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Thieme Open
publisher.none.fl_str_mv Thieme Open
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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