Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45918 |
Resumo: | Centro Universitário Dr. Leão Sampaio. Programa do Mestrado de Ensino em Saúde. Juazeiro do Norte, CE, Brasil. |
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Bitu, Vanessa de Carvalho NiloPereira, José Henrique AlvesFerreira, Vinícius de Carvalho Nilo BituRibeiro Filho, JaimeVega, Maria CelesteBoligon, Aline AugustiCoutinho, Henrique Douglas MeloMenezes, Irwin Rose Alencar de2021-02-02T12:26:24Z2021-02-02T12:26:24Z2020BITU, Vanessa de Carvalho Nilo et al. Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha. Brazilian Journal of health Review, Curitiba, v. 3, n. 6, p. 16525-16536, nov./dez.2020.2595-6825https://www.arca.fiocruz.br/handle/icict/4591810.34119/bjhrv3n6-074engDesconhecidoCephaelis ipecacuanhaLeishmania braziliensisLeishmania InfantumTrypanosoma CruziBiomarcadores TumoraisAntiprotozoáriaCephaelis ipecacuanhaLeishmania braziliensisLeishmania InfantumTrypanosoma CruziSecondary metabolites.Antiprotozoal activity.Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanhainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro Universitário Dr. Leão Sampaio. Programa do Mestrado de Ensino em Saúde. Juazeiro do Norte, CE, Brasil.Centro Universitário Dr. Leão Sampaio. Programa do Mestrado de Ensino em Saúde. Juazeiro do Norte, CE, Brasil.Universidade do Estado do Mato Grosso. Cáceres, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundación Moisés Bertoni. Centro para el Desarrollo de la Investigación Científica. Laboratorios Diaz Gill. Asuncion, Paraguay.Universidade Federal de Santa Maria. Santa Maria, RS, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Cephaelis ipecacuanha is a medicinal plant used in folk medicine for the treatment of amebiasis. However, the pharmacological properties of this species remain poorly understood. Objective: Characterize chemical composition and in vitro antiprotozoal activity of Cephaelis ipecacuanha. Method: The aqueous extract was lyophilized using the Chisrt Alpha apparatus and transferred to 96-well plates at concentrations ranging from 62.5 to 1000 μg / mL. The antiprotozoal activities against Trypanosoma cruzi, Leishmania brasiliensis, and L. infantum were evaluated after 72h incubation. Fibroblasts incubated at the same conditions for 24h were used as a cytotoxicity control. The readings were performed by spectrophotometry after staining with resazurin. The chemical composition of the extract was analyzed by High-Performance Liquid Chromatography (HPLC-DAD). Results: The results demonstrated that C. ipecacuanha had moderate antiprotozoal activity against T. cruzi. However, its cytotoxicity against the fibroblasts was significantly higher. Conclusion: This finding suggests that the use of this plant by the population, besides not having significant benefits, can cause associated health risks. Conclusão: Esse achado sugere que o uso dessa planta pela população, além de não apresentar benefícios significativos, pode acarretar riscos à saúde associados.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45918/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBITU et al Chemical Composition and In Vitro....2020 v.3 n.6 pg. 16525-16536.pdfBITU et al Chemical Composition and In Vitro....2020 v.3 n.6 pg. 16525-16536.pdfapplication/pdf580943https://www.arca.fiocruz.br/bitstream/icict/45918/2/BITU%20et%20al%20Chemical%20Composition%20and%20In%20Vitro....2020%20v.3%20n.6%20pg.%2016525-16536.pdf3c7c7dafb4ac057e9d2e176734ac07a7MD52TEXTBITU et al Chemical Composition and In Vitro....2020 v.3 n.6 pg. 16525-16536.pdf.txtBITU et al Chemical Composition and In Vitro....2020 v.3 n.6 pg. 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| dc.title.pt_BR.fl_str_mv |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| title |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| spellingShingle |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha Bitu, Vanessa de Carvalho Nilo Cephaelis ipecacuanha Leishmania braziliensis Leishmania Infantum Trypanosoma Cruzi Biomarcadores Tumorais Antiprotozoária Cephaelis ipecacuanha Leishmania braziliensis Leishmania Infantum Trypanosoma Cruzi Secondary metabolites. Antiprotozoal activity. |
| title_short |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| title_full |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| title_fullStr |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| title_full_unstemmed |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| title_sort |
Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha |
| author |
Bitu, Vanessa de Carvalho Nilo |
| author_facet |
Bitu, Vanessa de Carvalho Nilo Pereira, José Henrique Alves Ferreira, Vinícius de Carvalho Nilo Bitu Ribeiro Filho, Jaime Vega, Maria Celeste Boligon, Aline Augusti Coutinho, Henrique Douglas Melo Menezes, Irwin Rose Alencar de |
| author_role |
author |
| author2 |
Pereira, José Henrique Alves Ferreira, Vinícius de Carvalho Nilo Bitu Ribeiro Filho, Jaime Vega, Maria Celeste Boligon, Aline Augusti Coutinho, Henrique Douglas Melo Menezes, Irwin Rose Alencar de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bitu, Vanessa de Carvalho Nilo Pereira, José Henrique Alves Ferreira, Vinícius de Carvalho Nilo Bitu Ribeiro Filho, Jaime Vega, Maria Celeste Boligon, Aline Augusti Coutinho, Henrique Douglas Melo Menezes, Irwin Rose Alencar de |
| dc.subject.other.pt_BR.fl_str_mv |
Cephaelis ipecacuanha Leishmania braziliensis Leishmania Infantum Trypanosoma Cruzi Biomarcadores Tumorais Antiprotozoária |
| topic |
Cephaelis ipecacuanha Leishmania braziliensis Leishmania Infantum Trypanosoma Cruzi Biomarcadores Tumorais Antiprotozoária Cephaelis ipecacuanha Leishmania braziliensis Leishmania Infantum Trypanosoma Cruzi Secondary metabolites. Antiprotozoal activity. |
| dc.subject.en.pt_BR.fl_str_mv |
Cephaelis ipecacuanha Leishmania braziliensis Leishmania Infantum Trypanosoma Cruzi Secondary metabolites. Antiprotozoal activity. |
| description |
Centro Universitário Dr. Leão Sampaio. Programa do Mestrado de Ensino em Saúde. Juazeiro do Norte, CE, Brasil. |
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2020 |
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2020 |
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2021-02-02T12:26:24Z |
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2021-02-02T12:26:24Z |
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info:eu-repo/semantics/article |
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BITU, Vanessa de Carvalho Nilo et al. Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha. Brazilian Journal of health Review, Curitiba, v. 3, n. 6, p. 16525-16536, nov./dez.2020. |
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https://www.arca.fiocruz.br/handle/icict/45918 |
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2595-6825 |
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10.34119/bjhrv3n6-074 |
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BITU, Vanessa de Carvalho Nilo et al. Chemical Composition and In Vitro Antiprotozoal Properties of Cephaelis ipepacuanha. Brazilian Journal of health Review, Curitiba, v. 3, n. 6, p. 16525-16536, nov./dez.2020. 2595-6825 10.34119/bjhrv3n6-074 |
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