Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18090 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Departamento de Pediatria. Pneumologia Pediátrica. Rio de Janeiro, RJ, Brasil. |
| id |
CRUZ_7fca2a5fe68ce297043703df1207a3fd |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/18090 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Sad, Izabela RochaHiga, Laurinda Yoko ShinzatoLeal, TeresinhaMartins, Raisa da SilvaAlmeida, Ana Claudia deRamos, Eloane GoncalvesCabello, Giselda Maria Kalil dePeixoto, Maria Virginia Marques2017-03-21T11:48:36Z2017-03-21T11:48:36Z2016SAD, Izabela Rocha; et al. Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population. J. Clin. Med. Res., v.8, n.1, p.15-24, 2016.1918-3003https://www.arca.fiocruz.br/handle/icict/1809010.14740/jocmr2312w1918-3011engElmer PressFibrose císticaDiferença de potencial nasalTeste de diagnosticoRepetibilidadeÍndice de WilschanskiCystic fibrosisNasal potential differenceDiagnostic testRepeatabilityWilschanski indexSermet scoreRepeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Departamento de Pediatria. Pneumologia Pediátrica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Departamento de Pediatria. Pneumologia Pediátrica. Rio de Janeiro, RJ, Brasil.Universite Catholique de Louvain. Institut de Recherche Experimentale et Clinique (IREC). Louvain Center for Toxicology and Applied Pharmacology. Brussels, Belgium.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Departamento de Pediatria. Pneumologia Pediátrica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Laboratório de Métodos Quantitativos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Unidade de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Laboratório de Métodos Quantitativos. Rio de Janeiro, RJ, Brasil.The genetic diversity of the Brazilian population results from three ethnic groups admixture: Europeans, Africans and Amerindians, thus increasing the difficulty of performing cystic fibrosis (CF) diagnosis. The nasal potential difference (NPD) evaluates the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) activity. Despite being a useful CF diagnostic test and a biomarker of CFTR-modulator drugs, it is also highly operator dependent. Therefore, it may be difficult to get accurate results and to interpret them. Wilschanski and Sermet scores were proposed to address these issues. This study aimed to evaluate repeatability and diagnostic value of NPD parameters and Wilschanski and Sermet scores in a CF center in Rio de Janeiro.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18090/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALisabela_sad_etal_IOC_2106.pdfisabela_sad_etal_IOC_2106.pdfapplication/pdf992003https://www.arca.fiocruz.br/bitstream/icict/18090/2/isabela_sad_etal_IOC_2106.pdf0ef5a8584a240000637d1c3ef6d0bbdbMD52TEXTisabela_sad_etal_IOC_2106.pdf.txtisabela_sad_etal_IOC_2106.pdf.txtExtracted texttext/plain45127https://www.arca.fiocruz.br/bitstream/icict/18090/3/isabela_sad_etal_IOC_2106.pdf.txt1da32ccb6a64732fe5d0edbac078677eMD53icict/180902018-08-15 02:29:38.816oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T05:29:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| title |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| spellingShingle |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population Sad, Izabela Rocha Fibrose cística Diferença de potencial nasal Teste de diagnostico Repetibilidade Índice de Wilschanski Cystic fibrosis Nasal potential difference Diagnostic test Repeatability Wilschanski index Sermet score |
| title_short |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| title_full |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| title_fullStr |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| title_full_unstemmed |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| title_sort |
Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population |
| author |
Sad, Izabela Rocha |
| author_facet |
Sad, Izabela Rocha Higa, Laurinda Yoko Shinzato Leal, Teresinha Martins, Raisa da Silva Almeida, Ana Claudia de Ramos, Eloane Goncalves Cabello, Giselda Maria Kalil de Peixoto, Maria Virginia Marques |
| author_role |
author |
| author2 |
Higa, Laurinda Yoko Shinzato Leal, Teresinha Martins, Raisa da Silva Almeida, Ana Claudia de Ramos, Eloane Goncalves Cabello, Giselda Maria Kalil de Peixoto, Maria Virginia Marques |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sad, Izabela Rocha Higa, Laurinda Yoko Shinzato Leal, Teresinha Martins, Raisa da Silva Almeida, Ana Claudia de Ramos, Eloane Goncalves Cabello, Giselda Maria Kalil de Peixoto, Maria Virginia Marques |
| dc.subject.other.pt_BR.fl_str_mv |
Fibrose cística Diferença de potencial nasal Teste de diagnostico Repetibilidade Índice de Wilschanski |
| topic |
Fibrose cística Diferença de potencial nasal Teste de diagnostico Repetibilidade Índice de Wilschanski Cystic fibrosis Nasal potential difference Diagnostic test Repeatability Wilschanski index Sermet score |
| dc.subject.en.pt_BR.fl_str_mv |
Cystic fibrosis Nasal potential difference Diagnostic test Repeatability Wilschanski index Sermet score |
| description |
Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Departamento de Pediatria. Pneumologia Pediátrica. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016 |
| dc.date.accessioned.fl_str_mv |
2017-03-21T11:48:36Z |
| dc.date.available.fl_str_mv |
2017-03-21T11:48:36Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SAD, Izabela Rocha; et al. Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population. J. Clin. Med. Res., v.8, n.1, p.15-24, 2016. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18090 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1918-3003 |
| dc.identifier.doi.none.fl_str_mv |
10.14740/jocmr2312w |
| dc.identifier.eissn.none.fl_str_mv |
1918-3011 |
| identifier_str_mv |
SAD, Izabela Rocha; et al. Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population. J. Clin. Med. Res., v.8, n.1, p.15-24, 2016. 1918-3003 10.14740/jocmr2312w 1918-3011 |
| url |
https://www.arca.fiocruz.br/handle/icict/18090 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elmer Press |
| publisher.none.fl_str_mv |
Elmer Press |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/18090/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/18090/2/isabela_sad_etal_IOC_2106.pdf https://www.arca.fiocruz.br/bitstream/icict/18090/3/isabela_sad_etal_IOC_2106.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 0ef5a8584a240000637d1c3ef6d0bbdb 1da32ccb6a64732fe5d0edbac078677e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324957949722624 |