The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31341 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. |
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Bello, GonzaloNacher, MathieuDivino, FlaviaDarcissac, EdithMir, DaianaLacoste, Vincent2019-01-29T14:32:44Z2019-01-29T14:32:44Z2018BELLO, Gonzalo; et al. The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages. Frontiers in Microbiology, v.9, Article 1738, July 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3134110.3389/fmicb.2018.01738engFrontiers MediaHIV-1Subtipo BPandemiaFilodinâmicaGuiana FrancesaSurinameNão-pandemiaHIV-1Subtype BPandemicNon-pandemicPhylodynamicsFrench GuianaSurinameThe HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Coordination Régionale de la Lutte Contre le VIH and Centre d’Investigation Clinique INSERM 1424, Centre Hospitalier de Cayenne “Andrée Rosemon”, Cayenne, French Guiana.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Institut Pasteur de la Guyane. Laboratoire des Interactions Virus-Hôtes. Cayenne, French Guiana.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Institut Pasteur de la Guyane. Laboratoire des Interactions Virus-Hôtes. Cayenne, French Guiana.The HIV-1 subtype B epidemic in French Guiana and Suriname is characterized by the co-circulation of the globally disseminated “BPANDEMIC” lineage and of non-pandemic subtype B lineages of Caribbean origin (BCAR). To reconstruct the spatiotemporal pattern of spread of those viral lineages circulating in these two countries, a total of 361 HIV-1 subtype B pol sequences recovered from treatment-naive adult patients from French Guiana and Suriname between 2006 and 2012 were combined with BPANDEMIC and BCAR reference sequences. Major Guianese/Surinamese BPANDEMIC and BCAR lineages were identified by Maximum Likelihood phylogenetic analysis and the spatiotemporal and demographic parameters estimated using a Bayesian coalescent-based method. We detected four BCAR and three BPANDEMIC transmission chains of large size that together comprise most pandemic and non-pandemic subtype B sequences from French Guiana ( 52%) and Suriname ( 70%) here analyzed. These major lineages were probably introduced into French Guiana and Suriname from the Caribbean (BCAR) and North/South America (BPANDEMIC) between the middle 1970s and the late 1980s and spread among populations from both countries with roughly comparable demographic growth rates. We detected a significant trend for higher viral loads and higher proportion of homosexual/bisexual men among subjects infected with BPANDEMIC relative to BCAR strains in French Guiana. These results show that the HIV subtype B epidemic in French Guiana and Suriname has been driven by multiple active BCAR and BPANDEMIC transmission chains that arose since the middle 1970s onward and operate in both countries simultaneously. Although no significant differences in the epidemic potential of major BCAR and BPANDEMIC lineages were observed, relevant associations between the infecting subtype B lineage and epidemiological and clinical characteristics were detected in French Guiana.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31341/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo_Bello_etal_IOC_2018.pdfgonzalo_Bello_etal_IOC_2018.pdfapplication/pdf3206398https://www.arca.fiocruz.br/bitstream/icict/31341/2/gonzalo_Bello_etal_IOC_2018.pdfb1279d8c0f0b6077fedd894936b1d785MD52TEXTgonzalo_Bello_etal_IOC_2018.pdf.txtgonzalo_Bello_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
title |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
spellingShingle |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages Bello, Gonzalo HIV-1 Subtipo B Pandemia Filodinâmica Guiana Francesa Suriname Não-pandemia HIV-1 Subtype B Pandemic Non-pandemic Phylodynamics French Guiana Suriname |
title_short |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
title_full |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
title_fullStr |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
title_full_unstemmed |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
title_sort |
The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages |
author |
Bello, Gonzalo |
author_facet |
Bello, Gonzalo Nacher, Mathieu Divino, Flavia Darcissac, Edith Mir, Daiana Lacoste, Vincent |
author_role |
author |
author2 |
Nacher, Mathieu Divino, Flavia Darcissac, Edith Mir, Daiana Lacoste, Vincent |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Bello, Gonzalo Nacher, Mathieu Divino, Flavia Darcissac, Edith Mir, Daiana Lacoste, Vincent |
dc.subject.other.pt_BR.fl_str_mv |
HIV-1 Subtipo B Pandemia Filodinâmica Guiana Francesa Suriname Não-pandemia |
topic |
HIV-1 Subtipo B Pandemia Filodinâmica Guiana Francesa Suriname Não-pandemia HIV-1 Subtype B Pandemic Non-pandemic Phylodynamics French Guiana Suriname |
dc.subject.en.pt_BR.fl_str_mv |
HIV-1 Subtype B Pandemic Non-pandemic Phylodynamics French Guiana Suriname |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-01-29T14:32:44Z |
dc.date.available.fl_str_mv |
2019-01-29T14:32:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BELLO, Gonzalo; et al. The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages. Frontiers in Microbiology, v.9, Article 1738, July 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31341 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2018.01738 |
identifier_str_mv |
BELLO, Gonzalo; et al. The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages. Frontiers in Microbiology, v.9, Article 1738, July 2018. 1664-302X 10.3389/fmicb.2018.01738 |
url |
https://www.arca.fiocruz.br/handle/icict/31341 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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