The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages

Detalhes bibliográficos
Autor(a) principal: Bello, Gonzalo
Data de Publicação: 2018
Outros Autores: Nacher, Mathieu, Divino, Flavia, Darcissac, Edith, Mir, Daiana, Lacoste, Vincent
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31341
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
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spelling Bello, GonzaloNacher, MathieuDivino, FlaviaDarcissac, EdithMir, DaianaLacoste, Vincent2019-01-29T14:32:44Z2019-01-29T14:32:44Z2018BELLO, Gonzalo; et al. The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages. Frontiers in Microbiology, v.9, Article 1738, July 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3134110.3389/fmicb.2018.01738engFrontiers MediaHIV-1Subtipo BPandemiaFilodinâmicaGuiana FrancesaSurinameNão-pandemiaHIV-1Subtype BPandemicNon-pandemicPhylodynamicsFrench GuianaSurinameThe HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Coordination Régionale de la Lutte Contre le VIH and Centre d’Investigation Clinique INSERM 1424, Centre Hospitalier de Cayenne “Andrée Rosemon”, Cayenne, French Guiana.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Institut Pasteur de la Guyane. Laboratoire des Interactions Virus-Hôtes. Cayenne, French Guiana.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Institut Pasteur de la Guyane. Laboratoire des Interactions Virus-Hôtes. Cayenne, French Guiana.The HIV-1 subtype B epidemic in French Guiana and Suriname is characterized by the co-circulation of the globally disseminated “BPANDEMIC” lineage and of non-pandemic subtype B lineages of Caribbean origin (BCAR). To reconstruct the spatiotemporal pattern of spread of those viral lineages circulating in these two countries, a total of 361 HIV-1 subtype B pol sequences recovered from treatment-naive adult patients from French Guiana and Suriname between 2006 and 2012 were combined with BPANDEMIC and BCAR reference sequences. Major Guianese/Surinamese BPANDEMIC and BCAR lineages were identified by Maximum Likelihood phylogenetic analysis and the spatiotemporal and demographic parameters estimated using a Bayesian coalescent-based method. We detected four BCAR and three BPANDEMIC transmission chains of large size that together comprise most pandemic and non-pandemic subtype B sequences from French Guiana ( 52%) and Suriname ( 70%) here analyzed. These major lineages were probably introduced into French Guiana and Suriname from the Caribbean (BCAR) and North/South America (BPANDEMIC) between the middle 1970s and the late 1980s and spread among populations from both countries with roughly comparable demographic growth rates. We detected a significant trend for higher viral loads and higher proportion of homosexual/bisexual men among subjects infected with BPANDEMIC relative to BCAR strains in French Guiana. These results show that the HIV subtype B epidemic in French Guiana and Suriname has been driven by multiple active BCAR and BPANDEMIC transmission chains that arose since the middle 1970s onward and operate in both countries simultaneously. Although no significant differences in the epidemic potential of major BCAR and BPANDEMIC lineages were observed, relevant associations between the infecting subtype B lineage and epidemiological and clinical characteristics were detected in French Guiana.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31341/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo_Bello_etal_IOC_2018.pdfgonzalo_Bello_etal_IOC_2018.pdfapplication/pdf3206398https://www.arca.fiocruz.br/bitstream/icict/31341/2/gonzalo_Bello_etal_IOC_2018.pdfb1279d8c0f0b6077fedd894936b1d785MD52TEXTgonzalo_Bello_etal_IOC_2018.pdf.txtgonzalo_Bello_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
title The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
spellingShingle The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
Bello, Gonzalo
HIV-1
Subtipo B
Pandemia
Filodinâmica
Guiana Francesa
Suriname
Não-pandemia
HIV-1
Subtype B
Pandemic
Non-pandemic
Phylodynamics
French Guiana
Suriname
title_short The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
title_full The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
title_fullStr The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
title_full_unstemmed The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
title_sort The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages
author Bello, Gonzalo
author_facet Bello, Gonzalo
Nacher, Mathieu
Divino, Flavia
Darcissac, Edith
Mir, Daiana
Lacoste, Vincent
author_role author
author2 Nacher, Mathieu
Divino, Flavia
Darcissac, Edith
Mir, Daiana
Lacoste, Vincent
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bello, Gonzalo
Nacher, Mathieu
Divino, Flavia
Darcissac, Edith
Mir, Daiana
Lacoste, Vincent
dc.subject.other.pt_BR.fl_str_mv HIV-1
Subtipo B
Pandemia
Filodinâmica
Guiana Francesa
Suriname
Não-pandemia
topic HIV-1
Subtipo B
Pandemia
Filodinâmica
Guiana Francesa
Suriname
Não-pandemia
HIV-1
Subtype B
Pandemic
Non-pandemic
Phylodynamics
French Guiana
Suriname
dc.subject.en.pt_BR.fl_str_mv HIV-1
Subtype B
Pandemic
Non-pandemic
Phylodynamics
French Guiana
Suriname
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-29T14:32:44Z
dc.date.available.fl_str_mv 2019-01-29T14:32:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BELLO, Gonzalo; et al. The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages. Frontiers in Microbiology, v.9, Article 1738, July 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31341
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2018.01738
identifier_str_mv BELLO, Gonzalo; et al. The HIV-1 Subtype B Epidemic in French Guiana and Suriname Is Driven by Ongoing Transmissions of Pandemic and Non-pandemic Lineages. Frontiers in Microbiology, v.9, Article 1738, July 2018.
1664-302X
10.3389/fmicb.2018.01738
url https://www.arca.fiocruz.br/handle/icict/31341
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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