Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial

Detalhes bibliográficos
Autor(a) principal: Lago, Jamile
Data de Publicação: 2023
Outros Autores: Fraga, Deborah, Guimarães, Luiz Henrique, Lago, Tainã, Santos, Yuri, Lago, Ednaldo, Werneck, Guilherme L., Bacellar, Olívia, Carvalho, Edgar M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58930
Resumo: Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Curso de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.
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spelling Lago, JamileFraga, DeborahGuimarães, Luiz HenriqueLago, TainãSantos, YuriLago, EdnaldoWerneck, Guilherme L.Bacellar, OlíviaCarvalho, Edgar M.2023-06-05T18:34:25Z2023-06-05T18:34:25Z2023LAGO, Jamile et al. Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial. Plos Neglected Tropical Diseases, v. 17, n. 2, p. 1-10, 2023.1935-2735https://www.arca.fiocruz.br/handle/icict/5893010.1371/journal.pntd.0011064engPublic Library of ScienceAntimoniato de MegluminaLeishmaniose tegumentarEnsaio Clínico Controlado AleatórioMeglumine AntimoniateTegumentary leishmaniasisRandomized Controlled TrialAntimoniato de Megluminaleishmaniose tegumentarEnsaio Clínico Controlado AleatórioEfficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Curso de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Sul da Bahia. Teixeira de Freitas, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Curso de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Epidemiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Estudos em Saúde Pública. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Curso de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Curso de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well as asymptomatic L. braziliensis infection. It is not clear if dogs participate in the transmission chain of L. braziliensis to humans. However, dogs may remain with chronic ulcers for a long time, and as there are no public policies about CTL, these animals die or are sacrificed. Here we compare the efficacy of intralesional meglumine antimoniate with intralesional 0.9% NaCl solution in CTL treatment. This randomized control study included 32 dogs with cutaneous or muzzle lesions who had L. braziliensis DNA detected by PCR in tissue biopsied. Group one received 5ml of intralesional Glucantime, and group two received 5ml 0.9% NaCl solution, both applied in the four cardinal points on days 0, 15, and 30. Cure was defined as complete healing of the ulcers in the absence of raised borders on day 90. There was no difference in animals’ demographic and clinical features in the two groups (p >.05). While at the endpoint, the cure rate was 87.5% in the group test, and in those who received 0.9 NaCl the cure rate was only 12.5%. As important as the high cure rate, the healing time was faster in dogs treated with antimony than in those treated with saline (p < .001). Intralesional meglumine antimoniate is effective in the treatment of dogs with L. braziliensis infection and accelerates the healing time of CTL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58930/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLago, J. Efficacy of intralesional meglumine antimoniate ....pdfLago, J. Efficacy of intralesional meglumine antimoniate ....pdfapplication/pdf781668https://www.arca.fiocruz.br/bitstream/icict/58930/2/Lago%2c%20J.%20Efficacy%20of%20intralesional%20meglumine%20antimoniate%20....pdf90db84982af1660a4c2ea7ad110541d1MD52icict/589302023-06-05 15:34:26.938oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-05T18:34:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
title Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
spellingShingle Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
Lago, Jamile
Antimoniato de Meglumina
Leishmaniose tegumentar
Ensaio Clínico Controlado Aleatório
Meglumine Antimoniate
Tegumentary leishmaniasis
Randomized Controlled Trial
Antimoniato de Meglumina
leishmaniose tegumentar
Ensaio Clínico Controlado Aleatório
title_short Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
title_full Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
title_fullStr Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
title_full_unstemmed Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
title_sort Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial
author Lago, Jamile
author_facet Lago, Jamile
Fraga, Deborah
Guimarães, Luiz Henrique
Lago, Tainã
Santos, Yuri
Lago, Ednaldo
Werneck, Guilherme L.
Bacellar, Olívia
Carvalho, Edgar M.
author_role author
author2 Fraga, Deborah
Guimarães, Luiz Henrique
Lago, Tainã
Santos, Yuri
Lago, Ednaldo
Werneck, Guilherme L.
Bacellar, Olívia
Carvalho, Edgar M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lago, Jamile
Fraga, Deborah
Guimarães, Luiz Henrique
Lago, Tainã
Santos, Yuri
Lago, Ednaldo
Werneck, Guilherme L.
Bacellar, Olívia
Carvalho, Edgar M.
dc.subject.other.en_US.fl_str_mv Antimoniato de Meglumina
Leishmaniose tegumentar
Ensaio Clínico Controlado Aleatório
topic Antimoniato de Meglumina
Leishmaniose tegumentar
Ensaio Clínico Controlado Aleatório
Meglumine Antimoniate
Tegumentary leishmaniasis
Randomized Controlled Trial
Antimoniato de Meglumina
leishmaniose tegumentar
Ensaio Clínico Controlado Aleatório
dc.subject.en.en_US.fl_str_mv Meglumine Antimoniate
Tegumentary leishmaniasis
Randomized Controlled Trial
dc.subject.decs.en_US.fl_str_mv Antimoniato de Meglumina
leishmaniose tegumentar
Ensaio Clínico Controlado Aleatório
description Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Curso de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-05T18:34:25Z
dc.date.available.fl_str_mv 2023-06-05T18:34:25Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAGO, Jamile et al. Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial. Plos Neglected Tropical Diseases, v. 17, n. 2, p. 1-10, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58930
dc.identifier.issn.en_US.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0011064
identifier_str_mv LAGO, Jamile et al. Efficacy of intralesional meglumine antimoniate in the treatment of canine tegumentary leishmaniasis: a randomized controlled trial. Plos Neglected Tropical Diseases, v. 17, n. 2, p. 1-10, 2023.
1935-2735
10.1371/journal.pntd.0011064
url https://www.arca.fiocruz.br/handle/icict/58930
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58930/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58930/2/Lago%2c%20J.%20Efficacy%20of%20intralesional%20meglumine%20antimoniate%20....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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