Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Sarno, Alice
Data de Publicação: 2021
Outros Autores: Daltro, Cleidiane Borges, Mendes, Carlos Mauricio Cardeal, Bessa, Theolis Costa Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48696
Resumo: National Scientific and Technological Research Council (CNPq) [grant number 158967, 2015] and Bahia’s State Foundation for Research Support (FAPESB) [grant number BOL2647, 2013]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001
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spelling Sarno, AliceDaltro, Cleidiane BorgesMendes, Carlos Mauricio CardealBessa, Theolis Costa Barbosa2021-08-23T11:31:53Z2021-08-23T11:31:53Z2021SARNO, Alice et al. Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, p. 1-7, 2021.0037-8682https://www.arca.fiocruz.br/handle/icict/4869610.1590/0037-8682-0017-2021National Scientific and Technological Research Council (CNPq) [grant number 158967, 2015] and Bahia’s State Foundation for Research Support (FAPESB) [grant number BOL2647, 2013]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil.Introduction: Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world’s TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Promising antigen-based vaccines have been proposed as prophylactic and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens must interact with the range of human leukocyte antigen (HLA) molecules present in target populations; yet this information is currently not available. Methods: MEDLINE and EMBASE were systematically searched for articles published during 2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS. Results: In total, 67 articles involving 3,207,861 healthy individuals were included in the meta-analysis. HLA-DRB1 alleles *03, *04, *07, *11, *13, and *15 were consistently identified at high frequencies across the BRICS, with a combined estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, *12, and *14 were found to be relevant in only one or two BRICS populations. Conclusions: By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations.engSociedade Brasileira de Medicina TropicalTuberculoseVacinasMycobacterium bovisAntígenos HLAHistocompatibilidadeImunogenicidade da VacinaCadeias HLA-DRB1TuberculosisEpitope-based vaccineRational vaccine designVaccine candidateMajor histocompatibility complexImmunogenicityDistribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48696/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSarno, Alice Distribution....pdfSarno, Alice 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dc.title.pt_BR.fl_str_mv Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
title Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
spellingShingle Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
Sarno, Alice
Tuberculose
Vacinas
Mycobacterium bovis
Antígenos HLA
Histocompatibilidade
Imunogenicidade da Vacina
Cadeias HLA-DRB1
Tuberculosis
Epitope-based vaccine
Rational vaccine design
Vaccine candidate
Major histocompatibility complex
Immunogenicity
title_short Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
title_full Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
title_fullStr Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
title_full_unstemmed Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
title_sort Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
author Sarno, Alice
author_facet Sarno, Alice
Daltro, Cleidiane Borges
Mendes, Carlos Mauricio Cardeal
Bessa, Theolis Costa Barbosa
author_role author
author2 Daltro, Cleidiane Borges
Mendes, Carlos Mauricio Cardeal
Bessa, Theolis Costa Barbosa
author2_role author
author
author
dc.contributor.author.fl_str_mv Sarno, Alice
Daltro, Cleidiane Borges
Mendes, Carlos Mauricio Cardeal
Bessa, Theolis Costa Barbosa
dc.subject.other.pt_BR.fl_str_mv Tuberculose
Vacinas
Mycobacterium bovis
Antígenos HLA
Histocompatibilidade
Imunogenicidade da Vacina
Cadeias HLA-DRB1
topic Tuberculose
Vacinas
Mycobacterium bovis
Antígenos HLA
Histocompatibilidade
Imunogenicidade da Vacina
Cadeias HLA-DRB1
Tuberculosis
Epitope-based vaccine
Rational vaccine design
Vaccine candidate
Major histocompatibility complex
Immunogenicity
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Epitope-based vaccine
Rational vaccine design
Vaccine candidate
Major histocompatibility complex
Immunogenicity
description National Scientific and Technological Research Council (CNPq) [grant number 158967, 2015] and Bahia’s State Foundation for Research Support (FAPESB) [grant number BOL2647, 2013]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-23T11:31:53Z
dc.date.available.fl_str_mv 2021-08-23T11:31:53Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SARNO, Alice et al. Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, p. 1-7, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48696
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0017-2021
identifier_str_mv SARNO, Alice et al. Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, p. 1-7, 2021.
0037-8682
10.1590/0037-8682-0017-2021
url https://www.arca.fiocruz.br/handle/icict/48696
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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