Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11092 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil |
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Calvet, Guilherme AmaralVelasque, Luciane de SouzaLuz, Paula MendesCardoso, Sandra WagnerPedrosa, Monica DerricoMoreira, Ronaldo IsmérioAndrade, Angela Cristina Vasconcelos deCytryn, AndreaPires, ElaineSantos, Valdiléa Gonçalves Veloso dosGrinsztejn, BeatrizFriedman, Ruth Khalili2015-07-06T13:06:45Z2015-07-06T13:06:45Z2014CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1109210.1371/journal.pone.00892991932-6203engPublic Library of ScienceAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Matemática e Estatística. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilObjective: To compare the effectiveness of first-line combination antiretroviral therapy (cART) between premenopausal and postmenopausal women. Methods: ART-naı¨ve women initiating cART between January 2000/June 2010 at the Instituto de Pesquisa Clı´nica Evandro Chagas Cohort were studied. Women were defined as postmenopausal after 12 consecutive months of amenorrhea. CD4 cell counts and HIV-1 RNA viral load (VL) measurements were compared between pre- and postmenopausal at 6, 12 and 24 months after cART initiation. Women who modified/discontinued a drug class or died due to an AIDS defining illness were classified as ART-failures. Variables were compared using Wilcoxon test, x2 or Fisher’s exact test. The odds of cART effectiveness (VL,400 copies/mL and/or no need to change cART) were compared using logistic regression. Linear model was used to access relationship between CD4 change and menopause. Results: Among 383 women, 328 (85%) were premenopausal and 55 (15%) postmenopausal. Median pre cART CD4 counts were 231 and 208 cells/mm3 (p=0.14) in pre- and postmenopausal women, respectively. No difference in the median pre cART VL was found (both 4.8 copies/mL). Median CD4 changes were similar at 6 and 12 months. At 24 months after cART initiation, CD4 changes among postmenopausal women were significantly lower among premenopausal women (p=0.01). When the analysis was restricted to women with VL,400 copies/mL, no statistical difference was observed. Overall, 63.7% achieved cART effectiveness at 24 months without differences between groups at 6, 12 and 24 months. Conclusion: Menopause status at the time of first-line cART initiation does not impact CD4 cell changes at 24 months among women with a virologic response. No relationship between menopause status and virologic response was observed.Antiretroviral TherapyPremenopausePostmenopauseHIVMenopauseAnti-Retroviral AgentsCohort StudiesBrazil/ethnologyHighly ActiveTerapia Antirretroviral de Alta AtividadePré-MenopausaPós-MenopausaHIVMenopausaAntirretroviraisEstudos de CoortesBrasil/etnologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11092/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdfAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdfapplication/pdf104692https://www.arca.fiocruz.br/bitstream/icict/11092/2/Absence%20of%20effect%20of%20menopause%20status%20at%20initiation%20of%20first-line%20antiretroviral%20therapy%20on%20immunologic%20or%20virologic%20responses%20A%20cohort%20study%20from%20Rio%20de%20Janeiro%2c%20Brazil.pdf5af38dd1e354452d045751ee4890aa9eMD52TEXTAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdf.txtAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| title |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| spellingShingle |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil Calvet, Guilherme Amaral Antiretroviral Therapy Premenopause Postmenopause HIV Menopause Anti-Retroviral Agents Cohort Studies Brazil/ethnology Highly Active Terapia Antirretroviral de Alta Atividade Pré-Menopausa Pós-Menopausa HIV Menopausa Antirretrovirais Estudos de Coortes Brasil/etnologia |
| title_short |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| title_full |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| title_fullStr |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| title_full_unstemmed |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| title_sort |
Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil |
| author |
Calvet, Guilherme Amaral |
| author_facet |
Calvet, Guilherme Amaral Velasque, Luciane de Souza Luz, Paula Mendes Cardoso, Sandra Wagner Pedrosa, Monica Derrico Moreira, Ronaldo Ismério Andrade, Angela Cristina Vasconcelos de Cytryn, Andrea Pires, Elaine Santos, Valdiléa Gonçalves Veloso dos Grinsztejn, Beatriz Friedman, Ruth Khalili |
| author_role |
author |
| author2 |
Velasque, Luciane de Souza Luz, Paula Mendes Cardoso, Sandra Wagner Pedrosa, Monica Derrico Moreira, Ronaldo Ismério Andrade, Angela Cristina Vasconcelos de Cytryn, Andrea Pires, Elaine Santos, Valdiléa Gonçalves Veloso dos Grinsztejn, Beatriz Friedman, Ruth Khalili |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Calvet, Guilherme Amaral Velasque, Luciane de Souza Luz, Paula Mendes Cardoso, Sandra Wagner Pedrosa, Monica Derrico Moreira, Ronaldo Ismério Andrade, Angela Cristina Vasconcelos de Cytryn, Andrea Pires, Elaine Santos, Valdiléa Gonçalves Veloso dos Grinsztejn, Beatriz Friedman, Ruth Khalili |
| dc.subject.en.pt_BR.fl_str_mv |
Antiretroviral Therapy Premenopause Postmenopause HIV Menopause Anti-Retroviral Agents Cohort Studies Brazil/ethnology Highly Active |
| topic |
Antiretroviral Therapy Premenopause Postmenopause HIV Menopause Anti-Retroviral Agents Cohort Studies Brazil/ethnology Highly Active Terapia Antirretroviral de Alta Atividade Pré-Menopausa Pós-Menopausa HIV Menopausa Antirretrovirais Estudos de Coortes Brasil/etnologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Terapia Antirretroviral de Alta Atividade Pré-Menopausa Pós-Menopausa HIV Menopausa Antirretrovirais Estudos de Coortes Brasil/etnologia |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil |
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2014 |
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2014 |
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2015-07-06T13:06:45Z |
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2015-07-06T13:06:45Z |
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CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014. |
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https://www.arca.fiocruz.br/handle/icict/11092 |
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1932-6203 |
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10.1371/journal.pone.0089299 |
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1932-6203 |
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CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014. 1932-6203 10.1371/journal.pone.0089299 |
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Public Library of Science |
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