Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10552 |
Resumo: | Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil . |
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Leite, Fagner CarvalhoRibeiro Filho, JaimeCosta, Hermann FerreiraSalgado, Paula Regina RodriguesCalheiros, Andrea SurrageCarneiro, Alan BritoAlmeida, Reinaldo Nobrega deDias, Celidarque da SilvaBozza, Patricia TorresPiuvezam, Marcia Regina2015-05-27T13:39:52Z2015-05-27T13:39:52Z2014LEITE, Fagner Carvalho et al. Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain. Planta Med., v.80, n.13, p.1072-1078, aug. 2014.0032‑0943https://www.arca.fiocruz.br/handle/icict/1055210.1055/s-0034-1382997engGeorg Thieme Verlag KGCurine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Paininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil .Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil .Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Psicofarmacologia. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Psicofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Departamento de Ciências Farmacêuticas. Laboratório de Fitoquímica. João Pessoa, PB, Brasil.Curine is a bisbenzylisoquinoline alkaloid that is isolated from Chondrodendron platyphyllum, a plant that is used to treat malaria, inflammation, and pain. Recent reports have demonstrated the antiallergic effects of curine at nontoxic doses. However, its anti-inflammatory and analgesic properties remain to be elucidated. This study investigated the anti-inflammatory and analgesic effects of curine in mice. We analyzed the effects of an oral treatment with curine in the formation of paw edema, vascular permeability, abdominal contortion, licking behavior, and hyperalgesia using different inflammatory stimuli. Curine significantly inhibited the formation of paw edema by decreasing vascular permeability, inhibited the acetic acid-induced writhing response, inhibited the licking behavior during inflammation but not during the neurogenic phase of the formalin test, and inhibited carrageenan-induced hyperalgesia. Finally, curine inhibited prostaglandin E2 production in vitro without affecting cyclooxygenase-2 expression. The effects of curine treatment were similar to the effects of indomethacin, but were different from the effects of morphine treatment, suggesting that the analgesic effects of curine do not result from the direct inhibition of neuronal activation but instead depend on anti-inflammatory mechanisms that, at least in part, result from the inhibition of prostaglandin E2 production. In conclusion, curine presents anti-inflammatory and analgesic effects at nontoxic doses and has the potential for use in anti-inflammatory drug development.PainInflammationPGE2CurineChondrodendron platyphyllumMenispermaceaeMenispermaceaeDorInflamaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10552/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALandrea_calheirosetal_IOC_2014.pdfapplication/pdf179135https://www.arca.fiocruz.br/bitstream/icict/10552/2/andrea_calheirosetal_IOC_2014.pdf2fd469793ee7706daa823c19306c4119MD52TEXTandrea_calheirosetal_IOC_2014.pdf.txtandrea_calheirosetal_IOC_2014.pdf.txtExtracted texttext/plain37276https://www.arca.fiocruz.br/bitstream/icict/10552/3/andrea_calheirosetal_IOC_2014.pdf.txte23227e44f005a3f6b6b60b0aae5ff35MD53icict/105522022-06-24 12:19:35.251oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:19:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| title |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| spellingShingle |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain Leite, Fagner Carvalho Pain Inflammation PGE2 Curine Chondrodendron platyphyllum Menispermaceae Menispermaceae Dor Inflamação |
| title_short |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| title_full |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| title_fullStr |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| title_full_unstemmed |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| title_sort |
Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain |
| author |
Leite, Fagner Carvalho |
| author_facet |
Leite, Fagner Carvalho Ribeiro Filho, Jaime Costa, Hermann Ferreira Salgado, Paula Regina Rodrigues Calheiros, Andrea Surrage Carneiro, Alan Brito Almeida, Reinaldo Nobrega de Dias, Celidarque da Silva Bozza, Patricia Torres Piuvezam, Marcia Regina |
| author_role |
author |
| author2 |
Ribeiro Filho, Jaime Costa, Hermann Ferreira Salgado, Paula Regina Rodrigues Calheiros, Andrea Surrage Carneiro, Alan Brito Almeida, Reinaldo Nobrega de Dias, Celidarque da Silva Bozza, Patricia Torres Piuvezam, Marcia Regina |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Leite, Fagner Carvalho Ribeiro Filho, Jaime Costa, Hermann Ferreira Salgado, Paula Regina Rodrigues Calheiros, Andrea Surrage Carneiro, Alan Brito Almeida, Reinaldo Nobrega de Dias, Celidarque da Silva Bozza, Patricia Torres Piuvezam, Marcia Regina |
| dc.subject.en.pt_BR.fl_str_mv |
Pain Inflammation PGE2 Curine Chondrodendron platyphyllum Menispermaceae |
| topic |
Pain Inflammation PGE2 Curine Chondrodendron platyphyllum Menispermaceae Menispermaceae Dor Inflamação |
| dc.subject.decs.pt_BR.fl_str_mv |
Menispermaceae Dor Inflamação |
| description |
Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil . |
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2014 |
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2014 |
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2015-05-27T13:39:52Z |
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2015-05-27T13:39:52Z |
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LEITE, Fagner Carvalho et al. Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain. Planta Med., v.80, n.13, p.1072-1078, aug. 2014. |
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https://www.arca.fiocruz.br/handle/icict/10552 |
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0032‑0943 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1055/s-0034-1382997 |
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LEITE, Fagner Carvalho et al. Curine, an Alkaloid Isolated from Chondrodendron platyphyllum Inhibits Prostaglandin E2 in Experimental Models of Inflammation and Pain. Planta Med., v.80, n.13, p.1072-1078, aug. 2014. 0032‑0943 10.1055/s-0034-1382997 |
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Georg Thieme Verlag KG |
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Georg Thieme Verlag KG |
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