Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59305 https://doi.org/10.3390/ v15051073 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. |
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Fritsch, HeggerMoreno, KeldennLima, Italo Andrade BarbosaSantos, Cleiton SilvaCosta, Bernardo Gratival GouveaAlmeida, Breno Lima deSantos, Ronald Alves dosFrancisco, Marcos Vinicius Lima de OliveiraSampaio, Maria Paula SouzaLima, Maricelia Maia dePereira, Felicidade MotaFonseca, VagnerTosta, StephaneXavier, JoilsonOliveira, Carla deAdelino, TalitaMello, Arabela Leal e Silva deGräf, TiagoAlcantara, Luiz Carlos JuniorGiovanetti, MartaSiqueira, Isadora Cristina de2023-06-30T14:47:23Z2023-06-30T14:47:23Z2023FRITSCH, Hegger et al. Phylogenetic reconstructions reveal the circulation of a novel Dengue Virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil. Viruses, v. 15, n. 1073, p. 1-12, 2023.1999-4915https://www.arca.fiocruz.br/handle/icict/59305https://doi.org/10.3390/ v15051073porMDPIPhylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Secretaria Municipal de Saúde de Feira de Santana. Feira de Santana, BA, Brasil. / Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil.Laboratório Central de Saúde Pública Professor Gonçalo Moniz. Salvador, BA, Brasil.Organização Pan-Americana da Saúde. Brasília, DF, Brasil. / Organização Mundial da Saúde. Brasília, DF, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavívirus. Rio de Janeiro, RJ, Brasil.Fundação Ezequiel Dias. Laboratório Central de Saúde Pública do Estado de Minas Gerais. Belo Horizonte, MG, Brasil.Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. / Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico. Rome, Italy.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Dengue fever is among the most significant public health concerns in Brazil. To date, the highest number of Dengue notifications in the Americas has been reported in Brazil, with cases accounting for a total number of 3,418,796 reported cases as of mid-December 2022. Furthermore, the northeastern region of Brazil registered the second-highest incidence of Dengue fever in 2022. Due to the alarming epidemiological scenario, in this study, we used a combination of portable whole-genome sequencing, phylodynamic, and epidemiological analyses to reveal a novel DENV-1 genotype V clade and the persistence of DENV-2 genotype III in the region. We further report the presence of non-synonymous mutations associated with non-structural domains, especially the NS2A (non-structural protein 2A), as well as describe synonymous mutations in envelope and membrane proteins, distributed differently between clades. However, the absence of clinical data at the time of collection and notification, as well as the impossibility of monitoring patients in order to observe worsening or death, restricts our possibility of correlating mutational findings with possible clinical prognoses. Together, these results reinforce the crucial role of genomic surveillance to follow the evolution of circulating DENV strains and understand their spread across the region through interregional importation events, likely mediated by human mobility, and also the possible impacts on public health and outbreak management.Dengue VirusDengue FeverViral Nonstructural ProteinsGenomicsBrazilVirus del DengueProteínas no Estructurales ViralesGenómicaVirus de la dengueProtéines virales non structuralesGénomiqueBrasilVírus da DengueFebre da DengueProteínas não Estruturais ViraisGenômicaBrasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| title |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| spellingShingle |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil Fritsch, Hegger Dengue Virus Dengue Fever Viral Nonstructural Proteins Genomics Brazil Virus del Dengue Proteínas no Estructurales Virales Genómica Virus de la dengue Protéines virales non structurales Génomique Brasil Vírus da Dengue Febre da Dengue Proteínas não Estruturais Virais Genômica Brasil |
| title_short |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| title_full |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| title_fullStr |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| title_full_unstemmed |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| title_sort |
Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil |
| author |
Fritsch, Hegger |
| author_facet |
Fritsch, Hegger Moreno, Keldenn Lima, Italo Andrade Barbosa Santos, Cleiton Silva Costa, Bernardo Gratival Gouvea Almeida, Breno Lima de Santos, Ronald Alves dos Francisco, Marcos Vinicius Lima de Oliveira Sampaio, Maria Paula Souza Lima, Maricelia Maia de Pereira, Felicidade Mota Fonseca, Vagner Tosta, Stephane Xavier, Joilson Oliveira, Carla de Adelino, Talita Mello, Arabela Leal e Silva de Gräf, Tiago Alcantara, Luiz Carlos Junior Giovanetti, Marta Siqueira, Isadora Cristina de |
| author_role |
author |
| author2 |
Moreno, Keldenn Lima, Italo Andrade Barbosa Santos, Cleiton Silva Costa, Bernardo Gratival Gouvea Almeida, Breno Lima de Santos, Ronald Alves dos Francisco, Marcos Vinicius Lima de Oliveira Sampaio, Maria Paula Souza Lima, Maricelia Maia de Pereira, Felicidade Mota Fonseca, Vagner Tosta, Stephane Xavier, Joilson Oliveira, Carla de Adelino, Talita Mello, Arabela Leal e Silva de Gräf, Tiago Alcantara, Luiz Carlos Junior Giovanetti, Marta Siqueira, Isadora Cristina de |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fritsch, Hegger Moreno, Keldenn Lima, Italo Andrade Barbosa Santos, Cleiton Silva Costa, Bernardo Gratival Gouvea Almeida, Breno Lima de Santos, Ronald Alves dos Francisco, Marcos Vinicius Lima de Oliveira Sampaio, Maria Paula Souza Lima, Maricelia Maia de Pereira, Felicidade Mota Fonseca, Vagner Tosta, Stephane Xavier, Joilson Oliveira, Carla de Adelino, Talita Mello, Arabela Leal e Silva de Gräf, Tiago Alcantara, Luiz Carlos Junior Giovanetti, Marta Siqueira, Isadora Cristina de |
| dc.subject.en.en_US.fl_str_mv |
Dengue Virus Dengue Fever Viral Nonstructural Proteins Genomics Brazil |
| topic |
Dengue Virus Dengue Fever Viral Nonstructural Proteins Genomics Brazil Virus del Dengue Proteínas no Estructurales Virales Genómica Virus de la dengue Protéines virales non structurales Génomique Brasil Vírus da Dengue Febre da Dengue Proteínas não Estruturais Virais Genômica Brasil |
| dc.subject.es.en_US.fl_str_mv |
Virus del Dengue Proteínas no Estructurales Virales Genómica |
| dc.subject.fr.en_US.fl_str_mv |
Virus de la dengue Protéines virales non structurales Génomique Brasil |
| dc.subject.decs.en_US.fl_str_mv |
Vírus da Dengue Febre da Dengue Proteínas não Estruturais Virais Genômica Brasil |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. |
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2023 |
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2023-06-30T14:47:23Z |
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2023-06-30T14:47:23Z |
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2023 |
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info:eu-repo/semantics/article |
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FRITSCH, Hegger et al. Phylogenetic reconstructions reveal the circulation of a novel Dengue Virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil. Viruses, v. 15, n. 1073, p. 1-12, 2023. |
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https://www.arca.fiocruz.br/handle/icict/59305 |
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1999-4915 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3390/ v15051073 |
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FRITSCH, Hegger et al. Phylogenetic reconstructions reveal the circulation of a novel Dengue Virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil. Viruses, v. 15, n. 1073, p. 1-12, 2023. 1999-4915 |
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