Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 2006
Outros Autores: Baptista, Ana Paula, Santana, Thaynã Souto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/2807
Resumo: Fapesb, Pronex
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spelling Andrade, Zilton de AraújoBaptista, Ana PaulaSantana, Thaynã Souto2011-08-21T01:09:45Z2011-08-21T01:09:45Z2006ANDRADE, Z. de A.; BAPTISTA, A. P.; SANTANA, T. S. Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis. Memórias do Instituto Oswaldo Cruz. v. 101, supl. 1, p. 267-272, 20060074-0276https://www.arca.fiocruz.br/handle/icict/2807Fapesb, PronexFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA. BrasilHepatosplenic schistosomiasis was the first human disease in which the possibility of extensive long standing hepatic fibrosis being degraded and removed has been demonstrated. When such changes occurred, the main signs of portal hypertension (splenomegaly, esophageal varices) progressively disappeared, implying that a profound vascular remodeling was concomitantly occurring. Hepatic vascular alterations associated with advanced schistosomiasis have already been investigated. Obstruction of the intrahepatic portal vein branches, plus marked angiogenesis and compensatory hyperplasia and hypertrophy of the arterial tree are the main changes present. However, there are no data revealing how these vascular changes behave during the process of fibrosis regression. Here the mouse model of pipestem fibrosis was used in an investigation about these vascular alterations during the course of the infection, and also after treatment and cure of the disease. Animals representing the two polar hepatic forms of the infection were included: (1) [quot ]isolated granulomas[quot ] characterized by isolated periovular granulomas sparsely distributed throughout the hepatica parenchyma; and (2) 'pipestem fibrosis' with periovular granulomas and fibrosis being concentrated within portal spaces, before and after treatment, were studied by means of histological and vascular injection-corrosion techniques. Instances of widespread portal vein obstruction of several types were commonly found in the livers of the untreated animals. These obstructive lesions were soon repaired, and completely disappeared four months following specific treatment of schistosomiasis. Treatment was accomplished by the simultaneous administration of praziquantel and oxamniquine. The most impressive results were revealed by the technique of injection of colored masses into the portal system, followed by corrosion in strong acid. The vascular lesions of non-treated pipestem fibrosis were represented in the plastic casts by considerable diminution of the fine peripheral portal vein radicles, plus dilatation of periportal collaterals. Four months after treatment, this last picture appeared replaced by tufts of newly interwoven vessels formed along the main portal vein branches, disclosing a strong angiomatoid reparative change. Understanding about the cellular elements at play during fibro-vascular repairing changes of hepatic schistosomiasis represents a matter of considerable scientific and conceptual importance. At present time one may only speculate about the participation of some type of natural stem-cell capable of restoring the diseased liver back to normal once the cause of the disorder has been eliminated.engRemodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHepatic schistosomiasisVascular changesFibrosis reversionCirculação HepáticaCirrose HepáticaHepatopatias ParasitáriasSistema PortaEsquistossomose mansoniCamundongos Endogâmicos BALB CPraziquantelOxamniquineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRemodeling of hepatic vascular changes.pdfRemodeling of hepatic vascular changes.pdfapplication/pdf2862053https://www.arca.fiocruz.br/bitstream/icict/2807/1/Remodeling%20of%20hepatic%20vascular%20changes.pdf60dacecebccde9916a2c06f2c896889aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2807/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTRemodeling of hepatic vascular changes.pdf.txtRemodeling of hepatic vascular changes.pdf.txtExtracted texttext/plain21202https://www.arca.fiocruz.br/bitstream/icict/2807/5/Remodeling%20of%20hepatic%20vascular%20changes.pdf.txtf818abd48b41ccd45c343211e3ab27f9MD55THUMBNAILRemodeling of hepatic vascular changes.pdf.jpgRemodeling of hepatic vascular changes.pdf.jpgGenerated Thumbnailimage/jpeg2239https://www.arca.fiocruz.br/bitstream/icict/2807/4/Remodeling%20of%20hepatic%20vascular%20changes.pdf.jpg4076f701de9c372603cc02eab7827382MD54icict/28072023-03-15 14:33:05.252oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
title Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
spellingShingle Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
Andrade, Zilton de Araújo
Hepatic schistosomiasis
Vascular changes
Fibrosis reversion
Circulação Hepática
Cirrose Hepática
Hepatopatias Parasitárias
Sistema Porta
Esquistossomose mansoni
Camundongos Endogâmicos BALB C
Praziquantel
Oxamniquine
title_short Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
title_full Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
title_fullStr Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
title_full_unstemmed Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
title_sort Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Baptista, Ana Paula
Santana, Thaynã Souto
author_role author
author2 Baptista, Ana Paula
Santana, Thaynã Souto
author2_role author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Baptista, Ana Paula
Santana, Thaynã Souto
dc.subject.en.pt_BR.fl_str_mv Hepatic schistosomiasis
Vascular changes
Fibrosis reversion
topic Hepatic schistosomiasis
Vascular changes
Fibrosis reversion
Circulação Hepática
Cirrose Hepática
Hepatopatias Parasitárias
Sistema Porta
Esquistossomose mansoni
Camundongos Endogâmicos BALB C
Praziquantel
Oxamniquine
dc.subject.decs.pt_BR.fl_str_mv Circulação Hepática
Cirrose Hepática
Hepatopatias Parasitárias
Sistema Porta
Esquistossomose mansoni
Camundongos Endogâmicos BALB C
Praziquantel
Oxamniquine
description Fapesb, Pronex
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2011-08-21T01:09:45Z
dc.date.available.fl_str_mv 2011-08-21T01:09:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z. de A.; BAPTISTA, A. P.; SANTANA, T. S. Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis. Memórias do Instituto Oswaldo Cruz. v. 101, supl. 1, p. 267-272, 2006
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/2807
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, Z. de A.; BAPTISTA, A. P.; SANTANA, T. S. Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis. Memórias do Instituto Oswaldo Cruz. v. 101, supl. 1, p. 267-272, 2006
0074-0276
url https://www.arca.fiocruz.br/handle/icict/2807
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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