Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)

Detalhes bibliográficos
Autor(a) principal: Pereira, Polyana Silva
Data de Publicação: 2013
Outros Autores: Araujo, Carlos Felipe Machado de, Seki, Liliana Miyuki, Zahner, Viviane, Assef, Ana Paula D’Alincourt Carvalho, Asensi, Marise Dutra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12680
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.
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spelling Pereira, Polyana SilvaAraujo, Carlos Felipe Machado deSeki, Liliana MiyukiZahner, VivianeAssef, Ana Paula D’Alincourt CarvalhoAsensi, Marise Dutra2016-02-02T13:24:42Z2016-02-02T13:24:42Z2013PEREIRA, Polyana Silva; et al. Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother, v.68, p.312 –316, 2013.0305-7453https://www.arca.fiocruz.br/handle/icict/1268010.1093/jac/dks3961460-2091engOxford University PressUpdate of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.Objectives: To perform molecular epidemiology for 113 KPC-producing Klebsiella pneumoniae isolated in 2010 from 12 Brazilian states. Methods: The resistance profile was determined by disc diffusion and Etest. Genetic polymorphism was analysed by PFGE and multilocus sequence typing. The genetic environment of the blaKPC gene was determined by PCR and identification of the carrier plasmid was determined by hybridization. Results: Most of the isolates were multidrug resistant, with 15% and 49% being resistant to polymyxin and tigecycline, respectively. Twenty-two sequence types (STs) were observed, with ST11, ST437 and ST340 [clonal complex 11 (CC11)] being the most prevalent (75% of isolates) observed in 10 states. blaKPC-2 was associated with transposon Tn4401 ‘b’ and in 36% this gene was found in IncN plasmids of 40 kb. Conclusions: In Brazil, the spread of blaKPC-2 is occurring due to dispersion of Tn4401 ‘b’, carried by IncN plasmids of 40 kb, and mainly the dissemination of CC11, with ST437 and ST11 playing an important role.KPCK. pneumoniaeCC11Tn4401IncN plasmidsKlebsiella pneumoniaeBrasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12680/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpoliana_pereira_etal_IOC_2013.pdfpoliana_pereira_etal_IOC_2013.pdfapplication/pdf227622https://www.arca.fiocruz.br/bitstream/icict/12680/2/poliana_pereira_etal_IOC_2013.pdf205ba97f62c43a6bfcb93f8b97785b1bMD52TEXTpoliana_pereira_etal_IOC_2013.pdf.txtpoliana_pereira_etal_IOC_2013.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
title Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
spellingShingle Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
Pereira, Polyana Silva
KPC
K. pneumoniae
CC11
Tn4401
IncN plasmids
Klebsiella pneumoniae
Brasil
title_short Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
title_full Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
title_fullStr Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
title_full_unstemmed Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
title_sort Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)
author Pereira, Polyana Silva
author_facet Pereira, Polyana Silva
Araujo, Carlos Felipe Machado de
Seki, Liliana Miyuki
Zahner, Viviane
Assef, Ana Paula D’Alincourt Carvalho
Asensi, Marise Dutra
author_role author
author2 Araujo, Carlos Felipe Machado de
Seki, Liliana Miyuki
Zahner, Viviane
Assef, Ana Paula D’Alincourt Carvalho
Asensi, Marise Dutra
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Polyana Silva
Araujo, Carlos Felipe Machado de
Seki, Liliana Miyuki
Zahner, Viviane
Assef, Ana Paula D’Alincourt Carvalho
Asensi, Marise Dutra
dc.subject.en.pt_BR.fl_str_mv KPC
K. pneumoniae
CC11
Tn4401
IncN plasmids
topic KPC
K. pneumoniae
CC11
Tn4401
IncN plasmids
Klebsiella pneumoniae
Brasil
dc.subject.decs.pt_BR.fl_str_mv Klebsiella pneumoniae
Brasil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar (LAPIH). Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-02-02T13:24:42Z
dc.date.available.fl_str_mv 2016-02-02T13:24:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Polyana Silva; et al. Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother, v.68, p.312 –316, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12680
dc.identifier.issn.none.fl_str_mv 0305-7453
dc.identifier.doi.none.fl_str_mv 10.1093/jac/dks396
dc.identifier.eissn.none.fl_str_mv 1460-2091
identifier_str_mv PEREIRA, Polyana Silva; et al. Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother, v.68, p.312 –316, 2013.
0305-7453
10.1093/jac/dks396
1460-2091
url https://www.arca.fiocruz.br/handle/icict/12680
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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