Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7522 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil |
| id |
CRUZ_85a7f1df548c9a0ce3f087271f272e71 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/7522 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Pereira, Fernanda AlbuquerqueSilva, Naize Nara Pinheiro daRodart, Itatiana FerreiraCarmo, Theomira Mauadie de AzevedoLemaire, Denise CarneiroReis, Mitermayer Galvão dos2014-04-15T12:55:24Z2014-04-15T12:55:24Z2008PEREIRA, F. A. et al. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Journal of Medical Virology, v. 80, n. 1, p. 58-64, 2008.0146-6615https://www.arca.fiocruz.br/handle/icict/752210.1002/jmv.21011engWiley-Liss, INCAssociation of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilCytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), the production of abnormal cytokine levels appears to contribute to the progression of the disease, viral persistence, and affects response to therapy. Cytokine genes are polymorphic at specific sites, and certain polymorphisms located within coding/regulatory regions have been shown to affect the overall expression and secretion of cytokines. The aim of the present study was to identify potential markers of cytokines genes associated with the susceptibility to HCV infection. The cohort was composed of 128 individuals infected by HCV and 94 healthy controls. Genotyping was carried out by PCR-SSP. The distributions of the following polymorphisms were compared in these groups: TNF-alpha (-308G/A [rs1800629]), TGF-beta1 (codon 10 T/C [rs1982073], codon 25 G/C [rs1800471]), IL-10 (-1082 A/G [rs 1800896]; -819T/C [rs1800871]; -592A/C [rs 1800872]), IL-6 (-174G/C [rs1800795]), and IFN-gamma (+874T/A [rs2430561]). This study demonstrated a statistically significant difference in the frequency of TGF-beta1 codon 25 polymorphism between healthy subjects and those infected with HCV. No associations were observed between polymorphisms of TNF-alpha, IFN-gamma, IL-10, TGF-beta1 codon 10, and IL-6 and HCV infection. These findings suggest that TGF-beta1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection.Hepatitis CGenesCytokinesPolymorphism (genetics)Citocinas/genéticaPredisposição Genética para DoençaPredisposição Genética para DoençaPolimorfismo Genético/genéticaFator de Crescimento Transformador beta1/genéticaAdultoMarcadores BiológicosCódon/genéticaEstudos de CoortesFemininoPredisposição Genética para Doença/epidemiologiaGenótipoHepacivirus/químicaHepacivirus/genéticaHepatite C/fisiopatologiaHepatite C/virologiaHumanosMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPereira FA Association of TGF-B1....pdfPereira FA Association of TGF-B1....pdfapplication/pdf118428https://www.arca.fiocruz.br/bitstream/icict/7522/1/Pereira%20FA%20Association%20of%20TGF-B1....pdfb99cd45762246fcf378e3ff767691dfaMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7522/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTPereira FA Association of TGF-B1....pdf.txtPereira FA Association of TGF-B1....pdf.txtExtracted texttext/plain37234https://www.arca.fiocruz.br/bitstream/icict/7522/5/Pereira%20FA%20Association%20of%20TGF-B1....pdf.txtfac27270b573bbd8dd3ca3fba7ca627dMD55THUMBNAILPereira FA Association of TGF-B1....pdf.jpgPereira FA Association of TGF-B1....pdf.jpgGenerated Thumbnailimage/jpeg2460https://www.arca.fiocruz.br/bitstream/icict/7522/4/Pereira%20FA%20Association%20of%20TGF-B1....pdf.jpgb9707399c3994ba00cbb22eb16d0467cMD54icict/75222023-03-15 14:33:17.11oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| title |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| spellingShingle |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Pereira, Fernanda Albuquerque Hepatitis C Genes Cytokines Polymorphism (genetics) Citocinas/genética Predisposição Genética para Doença Predisposição Genética para Doença Polimorfismo Genético/genética Fator de Crescimento Transformador beta1/genética Adulto Marcadores Biológicos Códon/genética Estudos de Coortes Feminino Predisposição Genética para Doença/epidemiologia Genótipo Hepacivirus/química Hepacivirus/genética Hepatite C/fisiopatologia Hepatite C/virologia Humanos Masculino Meia-Idade |
| title_short |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| title_full |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| title_fullStr |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| title_full_unstemmed |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| title_sort |
Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. |
| author |
Pereira, Fernanda Albuquerque |
| author_facet |
Pereira, Fernanda Albuquerque Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie de Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão dos |
| author_role |
author |
| author2 |
Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie de Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão dos |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira, Fernanda Albuquerque Silva, Naize Nara Pinheiro da Rodart, Itatiana Ferreira Carmo, Theomira Mauadie de Azevedo Lemaire, Denise Carneiro Reis, Mitermayer Galvão dos |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis C Genes Cytokines Polymorphism (genetics) |
| topic |
Hepatitis C Genes Cytokines Polymorphism (genetics) Citocinas/genética Predisposição Genética para Doença Predisposição Genética para Doença Polimorfismo Genético/genética Fator de Crescimento Transformador beta1/genética Adulto Marcadores Biológicos Códon/genética Estudos de Coortes Feminino Predisposição Genética para Doença/epidemiologia Genótipo Hepacivirus/química Hepacivirus/genética Hepatite C/fisiopatologia Hepatite C/virologia Humanos Masculino Meia-Idade |
| dc.subject.decs.pt_BR.fl_str_mv |
Citocinas/genética Predisposição Genética para Doença Predisposição Genética para Doença Polimorfismo Genético/genética Fator de Crescimento Transformador beta1/genética Adulto Marcadores Biológicos Códon/genética Estudos de Coortes Feminino Predisposição Genética para Doença/epidemiologia Genótipo Hepacivirus/química Hepacivirus/genética Hepatite C/fisiopatologia Hepatite C/virologia Humanos Masculino Meia-Idade |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil |
| publishDate |
2008 |
| dc.date.issued.fl_str_mv |
2008 |
| dc.date.accessioned.fl_str_mv |
2014-04-15T12:55:24Z |
| dc.date.available.fl_str_mv |
2014-04-15T12:55:24Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PEREIRA, F. A. et al. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Journal of Medical Virology, v. 80, n. 1, p. 58-64, 2008. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7522 |
| dc.identifier.issn.none.fl_str_mv |
0146-6615 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/jmv.21011 |
| identifier_str_mv |
PEREIRA, F. A. et al. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Journal of Medical Virology, v. 80, n. 1, p. 58-64, 2008. 0146-6615 10.1002/jmv.21011 |
| url |
https://www.arca.fiocruz.br/handle/icict/7522 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Wiley-Liss, INC |
| publisher.none.fl_str_mv |
Wiley-Liss, INC |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/7522/1/Pereira%20FA%20Association%20of%20TGF-B1....pdf https://www.arca.fiocruz.br/bitstream/icict/7522/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/7522/5/Pereira%20FA%20Association%20of%20TGF-B1....pdf.txt https://www.arca.fiocruz.br/bitstream/icict/7522/4/Pereira%20FA%20Association%20of%20TGF-B1....pdf.jpg |
| bitstream.checksum.fl_str_mv |
b99cd45762246fcf378e3ff767691dfa 7d48279ffeed55da8dfe2f8e81f3b81f fac27270b573bbd8dd3ca3fba7ca627d b9707399c3994ba00cbb22eb16d0467c |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324740761321472 |