A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.

Detalhes bibliográficos
Autor(a) principal: Bittencourt, Achilea Candida Lisboa
Data de Publicação: 2009
Outros Autores: Mota, Karla Oliveira, Oliveira, Rodrigo Ferreira de, Vallve, Maria de Lourdes Farre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10649
Resumo: Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, Brasil
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spelling Bittencourt, Achilea Candida LisboaMota, Karla OliveiraOliveira, Rodrigo Ferreira deVallve, Maria de Lourdes Farre2015-06-08T12:41:07Z2015-06-08T12:41:07Z2009BITTENCOURT, A. C. L. et al. A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report. American Journal of Dermatopathology, v. 31, n. 8, p. 834-837, 2009.1533-0311https://www.arca.fiocruz.br/handle/icict/10649engLippincott Williams & WilkinsA dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilAdult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma associated with the human T-cell lymphotropic virus (HTLV-I). We describe an adult male patient clinically and pathologically diagnosed as mycosis fungoides and treated with chemotherapy after which complete involution of the lesions occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the palmoplantar regions, followed by disseminated vesiculopapules and associated lymphocytosis. A serological test performed at this time revealed HTLV-I infection, and a diagnosis of chronic ATL was made. Monoclonal integration of HTLV-I was detected in peripheral blood mononuclear cells by inverse long polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, and intraepidermal vesicles with atypical lymphocytes and an infiltration of small and atypical CD4 lymphocytes in the superficial dermis. Proliferative index (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with confirmation of HTLV-I proviral integration. The delay that occurred in diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the same clinical, histopathological, and immunohistochemical features.Adult T-cell leukemia/lymphoma,Mycosis fungoidesHTLV-I infectionEczema Disidrótico/patologiaInfecções por HTLV-I/patologiaLeucemia-Linfoma de Células T do Adulto/patologiaMicose Fungoide/patologiaNeoplasias Cutâneas/patologiaAdultoProtocolos de Quimioterapia Combinada Antineoplásica/uso terapêuticoCiclofosfamidaDiabetes MellitusDiagnóstico DiferencialDoxorrubicinaEczema Disidrótico/virologiaInfecções por HTLV-I/complicaçõesHumanosImuno-HistoquímicaLeucemia-Linfoma de Células T do Adulto/quimioterapiaMicose Fungoide/quimioterapiaNeoplasias Cutâneas/quimioterapiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10649/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALBittencourt AL A Dyshidrosis-like variant....pdfBittencourt AL A Dyshidrosis-like variant....pdfapplication/pdf643817https://www.arca.fiocruz.br/bitstream/icict/10649/2/Bittencourt%20AL%20%20A%20Dyshidrosis-like%20variant....pdf029144197d1cae7301115afae28abe2aMD52TEXTBittencourt AL A Dyshidrosis-like variant....pdf.txtBittencourt AL A Dyshidrosis-like variant....pdf.txtExtracted texttext/plain13411https://www.arca.fiocruz.br/bitstream/icict/10649/3/Bittencourt%20AL%20%20A%20Dyshidrosis-like%20variant....pdf.txt3665c355b42056b441e1993b1d7e71c9MD53icict/106492023-03-15 14:32:55.018oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
title A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
spellingShingle A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
Bittencourt, Achilea Candida Lisboa
Adult T-cell leukemia/lymphoma,
Mycosis fungoides
HTLV-I infection
Eczema Disidrótico/patologia
Infecções por HTLV-I/patologia
Leucemia-Linfoma de Células T do Adulto/patologia
Micose Fungoide/patologia
Neoplasias Cutâneas/patologia
Adulto
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Ciclofosfamida
Diabetes Mellitus
Diagnóstico Diferencial
Doxorrubicina
Eczema Disidrótico/virologia
Infecções por HTLV-I/complicações
Humanos
Imuno-Histoquímica
Leucemia-Linfoma de Células T do Adulto/quimioterapia
Micose Fungoide/quimioterapia
Neoplasias Cutâneas/quimioterapia
title_short A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
title_full A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
title_fullStr A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
title_full_unstemmed A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
title_sort A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
author Bittencourt, Achilea Candida Lisboa
author_facet Bittencourt, Achilea Candida Lisboa
Mota, Karla Oliveira
Oliveira, Rodrigo Ferreira de
Vallve, Maria de Lourdes Farre
author_role author
author2 Mota, Karla Oliveira
Oliveira, Rodrigo Ferreira de
Vallve, Maria de Lourdes Farre
author2_role author
author
author
dc.contributor.author.fl_str_mv Bittencourt, Achilea Candida Lisboa
Mota, Karla Oliveira
Oliveira, Rodrigo Ferreira de
Vallve, Maria de Lourdes Farre
dc.subject.en.pt_BR.fl_str_mv Adult T-cell leukemia/lymphoma,
Mycosis fungoides
HTLV-I infection
topic Adult T-cell leukemia/lymphoma,
Mycosis fungoides
HTLV-I infection
Eczema Disidrótico/patologia
Infecções por HTLV-I/patologia
Leucemia-Linfoma de Células T do Adulto/patologia
Micose Fungoide/patologia
Neoplasias Cutâneas/patologia
Adulto
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Ciclofosfamida
Diabetes Mellitus
Diagnóstico Diferencial
Doxorrubicina
Eczema Disidrótico/virologia
Infecções por HTLV-I/complicações
Humanos
Imuno-Histoquímica
Leucemia-Linfoma de Células T do Adulto/quimioterapia
Micose Fungoide/quimioterapia
Neoplasias Cutâneas/quimioterapia
dc.subject.decs.pt_BR.fl_str_mv Eczema Disidrótico/patologia
Infecções por HTLV-I/patologia
Leucemia-Linfoma de Células T do Adulto/patologia
Micose Fungoide/patologia
Neoplasias Cutâneas/patologia
Adulto
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Ciclofosfamida
Diabetes Mellitus
Diagnóstico Diferencial
Doxorrubicina
Eczema Disidrótico/virologia
Infecções por HTLV-I/complicações
Humanos
Imuno-Histoquímica
Leucemia-Linfoma de Células T do Adulto/quimioterapia
Micose Fungoide/quimioterapia
Neoplasias Cutâneas/quimioterapia
description Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-06-08T12:41:07Z
dc.date.available.fl_str_mv 2015-06-08T12:41:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BITTENCOURT, A. C. L. et al. A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report. American Journal of Dermatopathology, v. 31, n. 8, p. 834-837, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10649
dc.identifier.issn.none.fl_str_mv 1533-0311
identifier_str_mv BITTENCOURT, A. C. L. et al. A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report. American Journal of Dermatopathology, v. 31, n. 8, p. 834-837, 2009.
1533-0311
url https://www.arca.fiocruz.br/handle/icict/10649
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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