Auditory brainstem function in microcephaly related to Zika virus infection

Detalhes bibliográficos
Autor(a) principal: Abramov, Dimitri Marques
Data de Publicação: 2018
Outros Autores: Salles, Tania Regina Dias Saad, Gomes Junior, Saint Clair dos Santos, Silva, Daniel de Souza e, Araújo, Izabel, Moreira, Maria Elisabeth Lopes, Lazarev, Vladimir V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30598
Resumo: 2019-01-19
id CRUZ_85d5fa40b95fcf2431f4e8d4dd7d8212
oai_identifier_str oai:www.arca.fiocruz.br:icict/30598
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Abramov, Dimitri MarquesSalles, Tania Regina Dias SaadGomes Junior, Saint Clair dos SantosSilva, Daniel de Souza eAraújo, IzabelMoreira, Maria Elisabeth LopesLazarev, Vladimir V.2018-12-14T17:53:22Z2018-12-14T17:53:22Z2018ABRAMOV, Dimitri Marques et al. Auditory brainstem function in microcephaly related to Zika virus infection. Neurology, v. 90, n. 7. p. e606-e614, 2018.0028-3878https://www.arca.fiocruz.br/handle/icict/3059810.1212/WNL.0000000000004974engAmerican Academy of NeurologyFunção Auditiva do Tronco CerebralMicrocefaliaZika VirusAuditory brainstem functionMicrocephalyZika VirusAuditory brainstem function in microcephaly related to Zika virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-01-19Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Neurobiologia e Neurofisiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Neurobiologia e Neurofisiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Neurobiologia e Neurofisiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Neurobiologia e Neurofisiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Laboratório de Neurobiologia e Neurofisiologia Clínica. Rio de Janeiro, RJ, Brasil.OBJECTIVE: To study the effect of prenatal Zika virus (ZV) infection on brainstem function reflected in brainstem auditory evoked potentials (BAEPs). METHODS: In a cross-sectional study in 19 children (12 girls) with microcephaly related to ZV infection, aged between 12 and 62 weeks, the brainstem function was examined through BAEPs. The latencies of wave peaks I, III, and V of the left and right ears (n = 37) were standardized according to normative data, and compared between them by 2-tailed t test. The confounding variables (cephalic perimeter at the born and chronological age) were correlated with the normalized latencies using Pearson test. RESULTS: All patients showed, in general, clear waveforms, with latencies within 3 SDs of the normative values. However, statistically increased latencies of waves I and III (I > III, p = 0.031) were observed, relative to wave V (p < 0.001), the latter being closer to respective normative value. The latency of wave I was observed to increase with age (r = 0.45, p = 0.005). The waves, in turn, did not depend on cephalic perimeter. CONCLUSIONS: These results are consistent with the functional normality of the brainstem structure and its lack of correlation with microcephaly, suggesting that the disruption produced by the ZV infection does not act in the cell proliferation phase, but mostly in the processes of neuronal migration and differentiation in the telencephalon.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83142https://www.arca.fiocruz.br/bitstream/icict/30598/1/license.txt37a74d92f1f1fd437ab11671160e0230MD51ORIGINALve_Abramov_Dimitri_Marques_2018.pdfve_Abramov_Dimitri_Marques_2018.pdfapplication/pdf550982https://www.arca.fiocruz.br/bitstream/icict/30598/2/ve_Abramov_Dimitri_Marques_2018.pdf64f8854566f09a14f6a26dfa164aae96MD52TEXTve_Abramov_Dimitri_Marques_2018.pdf.txtve_Abramov_Dimitri_Marques_2018.pdf.txtExtracted texttext/plain33407https://www.arca.fiocruz.br/bitstream/icict/30598/3/ve_Abramov_Dimitri_Marques_2018.pdf.txt9dde98eff1b2b11094f0bb09a0daba99MD53icict/305982021-02-10 19:38:06.288oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-02-10T22:38:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Auditory brainstem function in microcephaly related to Zika virus infection
title Auditory brainstem function in microcephaly related to Zika virus infection
spellingShingle Auditory brainstem function in microcephaly related to Zika virus infection
Abramov, Dimitri Marques
Função Auditiva do Tronco Cerebral
Microcefalia
Zika Virus
Auditory brainstem function
Microcephaly
Zika Virus
title_short Auditory brainstem function in microcephaly related to Zika virus infection
title_full Auditory brainstem function in microcephaly related to Zika virus infection
title_fullStr Auditory brainstem function in microcephaly related to Zika virus infection
title_full_unstemmed Auditory brainstem function in microcephaly related to Zika virus infection
title_sort Auditory brainstem function in microcephaly related to Zika virus infection
author Abramov, Dimitri Marques
author_facet Abramov, Dimitri Marques
Salles, Tania Regina Dias Saad
Gomes Junior, Saint Clair dos Santos
Silva, Daniel de Souza e
Araújo, Izabel
Moreira, Maria Elisabeth Lopes
Lazarev, Vladimir V.
author_role author
author2 Salles, Tania Regina Dias Saad
Gomes Junior, Saint Clair dos Santos
Silva, Daniel de Souza e
Araújo, Izabel
Moreira, Maria Elisabeth Lopes
Lazarev, Vladimir V.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Abramov, Dimitri Marques
Salles, Tania Regina Dias Saad
Gomes Junior, Saint Clair dos Santos
Silva, Daniel de Souza e
Araújo, Izabel
Moreira, Maria Elisabeth Lopes
Lazarev, Vladimir V.
dc.subject.other.pt_BR.fl_str_mv Função Auditiva do Tronco Cerebral
Microcefalia
Zika Virus
topic Função Auditiva do Tronco Cerebral
Microcefalia
Zika Virus
Auditory brainstem function
Microcephaly
Zika Virus
dc.subject.en.pt_BR.fl_str_mv Auditory brainstem function
Microcephaly
Zika Virus
description 2019-01-19
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-14T17:53:22Z
dc.date.available.fl_str_mv 2018-12-14T17:53:22Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABRAMOV, Dimitri Marques et al. Auditory brainstem function in microcephaly related to Zika virus infection. Neurology, v. 90, n. 7. p. e606-e614, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30598
dc.identifier.issn.pt_BR.fl_str_mv 0028-3878
dc.identifier.doi.none.fl_str_mv 10.1212/WNL.0000000000004974
identifier_str_mv ABRAMOV, Dimitri Marques et al. Auditory brainstem function in microcephaly related to Zika virus infection. Neurology, v. 90, n. 7. p. e606-e614, 2018.
0028-3878
10.1212/WNL.0000000000004974
url https://www.arca.fiocruz.br/handle/icict/30598
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Academy of Neurology
publisher.none.fl_str_mv American Academy of Neurology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30598/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/30598/2/ve_Abramov_Dimitri_Marques_2018.pdf
https://www.arca.fiocruz.br/bitstream/icict/30598/3/ve_Abramov_Dimitri_Marques_2018.pdf.txt
bitstream.checksum.fl_str_mv 37a74d92f1f1fd437ab11671160e0230
64f8854566f09a14f6a26dfa164aae96
9dde98eff1b2b11094f0bb09a0daba99
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009018731364352

Registros relacionados