Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment

Andrade, Sonia Gumes; Magalhães, Lorena dos Anjos; Pessina, Daniel Huber

Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment

Detalhes bibliográficos
Autor(a) principal:	Andrade, Sonia Gumes
Data de Publicação:	2008
Outros Autores:	Magalhães, Lorena dos Anjos, Pessina, Daniel Huber
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/2792
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunidade Celular. Salvador, BA, Brasil

Metadados do item

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spelling	Andrade, Sonia GumesMagalhães, Lorena dos AnjosPessina, Daniel Huber2011-08-10T13:57:49Z2011-08-10T13:57:49Z2008ANDRADE, S. G.; MAGALHÃES, L. dos A.; PESSINA, D. H. Importance of TNF-a in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment. Memórias do Instituto Oswaldo Cruz, v.103, n.1, p.21-26, fev. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/2792engFundação Oswaldo CruzTrypanosoma cruziNecroseBaçoTNF-αPentoxifilinaTrypanosoma cruziNecrosisSpleenTNF-αPentoxifyllineTrypanosoma cruziNecroseBaçoFator de Necrose Tumoral AlfaPentoxifilinaImportance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunidade Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunidade Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunidade Celular. Salvador, BA, BrasilInfection of C3H/He mice with the Peruvian strain of Trypanosoma cruzi (Biodeme type I, Z2b), a macrophagotropic strain, determined severe parasitism of macrophages, necrosis of the spleen, and high host mortality. In the present study, pentoxifylline (PTX), an inhibitor of TNF-a was investigated on its action upon splenic necrosis, parasitemia and host survival. Immunohistochemical data suggested the importance of this cytokine in parasite destruction and decreasing of parasitemia, although paradoxically contributing to the high mortality of infected mice. Necrotic lesions involving several organs, specially the heart, in acute Chagas disease, are important aggravating factors, increasing cardiac morbidity. Advantage of inhibiting TNF-a action was herein investigated. Infected mice were divided into two groups: untreated (n = 24), and PTX treated mice (n = 25). PTX was administered in two daily doses of 30 mg/kg/bw, by intraperitoneal route. Normal controls either treated with PTX or saline were also included. Histopathology of the spleen and in situ immunolabeling of TNF-a, using anti-TNF-a monoclonal antibody, were performed. Necrotic areas were evaluated by morphometry. Mice treated with PTX showed a significant decrease of necrotic areas and diminution of TNF-a expression in spleen tissue, suggesting that PTX treatment could control TNF-a effects, and thus be used as an adjuvant in the treatment of acute Chagas’ disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade_Magalhaes_Pessina.pdfAndrade_Magalhaes_Pessina.pdfapplication/pdf2647330https://www.arca.fiocruz.br/bitstream/icict/2792/1/Andrade_Magalhaes_Pessina.pdfb522cd340878229ffd457a0da7a2d362MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2792/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAndrade_Magalhaes_Pessina.pdf.txtAndrade_Magalhaes_Pessina.pdf.txtExtracted texttext/plain30084https://www.arca.fiocruz.br/bitstream/icict/2792/5/Andrade_Magalhaes_Pessina.pdf.txt7177d2c13dd2b829275d4f98e4146f2dMD55THUMBNAILAndrade_Magalhaes_Pessina.pdf.jpgAndrade_Magalhaes_Pessina.pdf.jpgGenerated Thumbnailimage/jpeg2408https://www.arca.fiocruz.br/bitstream/icict/2792/4/Andrade_Magalhaes_Pessina.pdf.jpg7d4c0284571df24106d1211bfad627eeMD54icict/27922023-03-15 14:34:09.255oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
title	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
spellingShingle	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment Andrade, Sonia Gumes Trypanosoma cruzi Necrose Baço TNF-α Pentoxifilina Trypanosoma cruzi Necrosis Spleen TNF-α Pentoxifylline Trypanosoma cruzi Necrose Baço Fator de Necrose Tumoral Alfa Pentoxifilina
title_short	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
title_full	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
title_fullStr	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
title_full_unstemmed	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
title_sort	Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
author	Andrade, Sonia Gumes
author_facet	Andrade, Sonia Gumes Magalhães, Lorena dos Anjos Pessina, Daniel Huber
author_role	author
author2	Magalhães, Lorena dos Anjos Pessina, Daniel Huber
author2_role	author author
dc.contributor.author.fl_str_mv	Andrade, Sonia Gumes Magalhães, Lorena dos Anjos Pessina, Daniel Huber
dc.subject.other.pt_BR.fl_str_mv	Trypanosoma cruzi Necrose Baço TNF-α Pentoxifilina
topic	Trypanosoma cruzi Necrose Baço TNF-α Pentoxifilina Trypanosoma cruzi Necrosis Spleen TNF-α Pentoxifylline Trypanosoma cruzi Necrose Baço Fator de Necrose Tumoral Alfa Pentoxifilina
dc.subject.en.pt_BR.fl_str_mv	Trypanosoma cruzi Necrosis Spleen TNF-α Pentoxifylline
dc.subject.decs.pt_BR.fl_str_mv	Trypanosoma cruzi Necrose Baço Fator de Necrose Tumoral Alfa Pentoxifilina
description	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental, Autoimunidade e Imunidade Celular. Salvador, BA, Brasil
publishDate	2008
dc.date.issued.fl_str_mv	2008
dc.date.accessioned.fl_str_mv	2011-08-10T13:57:49Z
dc.date.available.fl_str_mv	2011-08-10T13:57:49Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ANDRADE, S. G.; MAGALHÃES, L. dos A.; PESSINA, D. H. Importance of TNF-a in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment. Memórias do Instituto Oswaldo Cruz, v.103, n.1, p.21-26, fev. 2008.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/2792
dc.identifier.issn.none.fl_str_mv	0074-0276
identifier_str_mv	ANDRADE, S. G.; MAGALHÃES, L. dos A.; PESSINA, D. H. Importance of TNF-a in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment. Memórias do Instituto Oswaldo Cruz, v.103, n.1, p.21-26, fev. 2008. 0074-0276
url	https://www.arca.fiocruz.br/handle/icict/2792
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Fundação Oswaldo Cruz
publisher.none.fl_str_mv	Fundação Oswaldo Cruz
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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Importance of TNF-α in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment

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