Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10382 |
Resumo: | CNPq, FAPERJ, NIH |
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Passaes, Caroline Pereira BittencourtCardoso, Cynthia ChesterCaetano, Diogo GamaTeixeira, Sylvia Lopes MaiaGuimarães, Monick LindenmeyerCampos, Dayse PereiraVeloso, Valdiléa G.Babic, Dunja Z.Stevenson, MarioMoraes, Milton OzórioMorgado, Mariza Gonçalves2015-05-18T15:47:45Z2015-05-18T15:47:45Z2014PASSAES, Caroline Pereira Bittencourt et al. Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals. Plos One, v. 9, n. 7, p. 1-8, July 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1038210.1371/journal.pone.01017801932-6203CNPq, FAPERJ, NIHFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Genética. Laboratório de Virologia Molecular Animal. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Miami. Miller School of Medicine. Department of Medicine. Division of Infectious Diseases. Miami, FL, USA.University of Miami. Miller School of Medicine. Department of Medicine. Division of Infectious Diseases. Miami, FL, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The lens epithelium-derived growth factor p75 (LEDGF/p75), coded by the PSIP1 gene, is an important host co-factor that interacts with HIV-1 integrase to target integration of viral cDNA into active genes. The aim of this study was to investigate the association of SNPs in the PSIP1 gene with disease outcome in HIV-1 infected patients. We performed a genetic association study in a cohort of 171 HIV-1 seropositive Brazilian individuals classified as rapid progressors (RP, n = 69), typical progressors (TP, n = 79) and long-term nonprogressors (LTNP, n = 23). The exonic SNP rs61744944 and 9 tag SNPs were genotyped. A group of 192 healthy subjects was analyzed to determine the frequency of SNPs and haplotypes in the general population. Linkage disequilibrium (LD) analyses indicated that the SNPs analyzed were not in high LD (r2,0.8). Logistic regression models suggested that patients carrying the T allele rs61744944 (472L) were more likely to develop a LTNP phenotype (OR = 4.98; p = 0.05) as compared to TP group. The same trend was observed when LTNPs were compared to the RP group (OR = 3.26). Results of haplotype analyses reinforced this association, since the OR values obtained for the haplotype carrying allele T at rs61744944 also reflected an association with LTNP status (OR = 6.05; p = 0.08 and OR = 3.44; p = 0.12 for comparisons to TP and RP, respectively). The rare missense variations Ile436Ser and Thr473Ile were not identified in the patients enrolled in this study. Gene expression analyses showed lower LEDGF/p75 mRNA levels in peripheral blood mononuclear cells obtained from HIV-1 infected individuals. However, these levels were not influenced by any of the SNPs investigated. In spite of the limited number of LTNPs, these data suggest that the PSIP1 gene could be associated with the outcome of HIV-1 infection. Further analyses of this gene may guide the identification of causative variants to help predict disease course.engPublic Library of ScienceAssociation of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAcquired Immunodeficiency SyndromeHIV InfectionsAntigens, CD4HIV-1Síndrome de Imunodeficiência AdquiridaInfecções por HIVAntígenos CD4HIV-1info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10382/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALAssociation of Single Nucleotide Polymorphisms in the Lens Epithelium-Derived Growth Factor LEDGFp75 with HIV-1 Infection Outcomes in Brazilian HIV-1+ Individuals.pdfAssociation of Single Nucleotide Polymorphisms in the Lens Epithelium-Derived Growth Factor LEDGFp75 with HIV-1 Infection Outcomes in Brazilian HIV-1+ Individuals.pdfapplication/pdf387206https://www.arca.fiocruz.br/bitstream/icict/10382/2/Association%20of%20Single%20Nucleotide%20Polymorphisms%20in%20the%20Lens%20Epithelium-Derived%20Growth%20Factor%20LEDGFp75%20with%20HIV-1%20Infection%20Outcomes%20in%20Brazilian%20HIV-1%2b%20Individuals.pdfe60d077bb602e0c2f75857c9ca9cd7b7MD52TEXTAssociation of Single Nucleotide Polymorphisms in the Lens Epithelium-Derived Growth Factor LEDGFp75 with HIV-1 Infection Outcomes in Brazilian HIV-1+ Individuals.pdf.txtAssociation of Single Nucleotide Polymorphisms in the Lens Epithelium-Derived Growth Factor LEDGFp75 with HIV-1 Infection Outcomes in Brazilian HIV-1+ Individuals.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| title |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| spellingShingle |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals Passaes, Caroline Pereira Bittencourt Acquired Immunodeficiency Syndrome HIV Infections Antigens, CD4 HIV-1 Síndrome de Imunodeficiência Adquirida Infecções por HIV Antígenos CD4 HIV-1 |
| title_short |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| title_full |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| title_fullStr |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| title_full_unstemmed |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| title_sort |
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals |
| author |
Passaes, Caroline Pereira Bittencourt |
| author_facet |
Passaes, Caroline Pereira Bittencourt Cardoso, Cynthia Chester Caetano, Diogo Gama Teixeira, Sylvia Lopes Maia Guimarães, Monick Lindenmeyer Campos, Dayse Pereira Veloso, Valdiléa G. Babic, Dunja Z. Stevenson, Mario Moraes, Milton Ozório Morgado, Mariza Gonçalves |
| author_role |
author |
| author2 |
Cardoso, Cynthia Chester Caetano, Diogo Gama Teixeira, Sylvia Lopes Maia Guimarães, Monick Lindenmeyer Campos, Dayse Pereira Veloso, Valdiléa G. Babic, Dunja Z. Stevenson, Mario Moraes, Milton Ozório Morgado, Mariza Gonçalves |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Passaes, Caroline Pereira Bittencourt Cardoso, Cynthia Chester Caetano, Diogo Gama Teixeira, Sylvia Lopes Maia Guimarães, Monick Lindenmeyer Campos, Dayse Pereira Veloso, Valdiléa G. Babic, Dunja Z. Stevenson, Mario Moraes, Milton Ozório Morgado, Mariza Gonçalves |
| dc.subject.en.pt_BR.fl_str_mv |
Acquired Immunodeficiency Syndrome HIV Infections Antigens, CD4 HIV-1 |
| topic |
Acquired Immunodeficiency Syndrome HIV Infections Antigens, CD4 HIV-1 Síndrome de Imunodeficiência Adquirida Infecções por HIV Antígenos CD4 HIV-1 |
| dc.subject.decs.pt_BR.fl_str_mv |
Síndrome de Imunodeficiência Adquirida Infecções por HIV Antígenos CD4 HIV-1 |
| description |
CNPq, FAPERJ, NIH |
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2014 |
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2014 |
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2015-05-18T15:47:45Z |
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2015-05-18T15:47:45Z |
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PASSAES, Caroline Pereira Bittencourt et al. Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals. Plos One, v. 9, n. 7, p. 1-8, July 2014. |
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https://www.arca.fiocruz.br/handle/icict/10382 |
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1932-6203 |
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10.1371/journal.pone.0101780 |
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1932-6203 |
| identifier_str_mv |
PASSAES, Caroline Pereira Bittencourt et al. Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals. Plos One, v. 9, n. 7, p. 1-8, July 2014. 1932-6203 10.1371/journal.pone.0101780 |
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Public Library of Science |
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Public Library of Science |
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