The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.

Detalhes bibliográficos
Autor(a) principal: Maia Junior, Hugo
Data de Publicação: 2008
Outros Autores: Casoy, Julio, Correia, Tania Maria, Freitas, Luiz Antonio Rodrigues de, Pimentel, Kleber, Athayde, Célia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7808
Resumo: Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, Brasil
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spelling Maia Junior, HugoCasoy, JulioCorreia, Tania MariaFreitas, Luiz Antonio Rodrigues dePimentel, KleberAthayde, Célia2014-06-09T19:38:29Z2014-06-09T19:38:29Z2008MAIA JUNIOR, H. et al. The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis. Gynecologyical Endocrinology, v. 24, n. 3, p. 123-128, 2008.0951-3590https://www.arca.fiocruz.br/handle/icict/780810.1080/09513590801890816engInforma HealthcareThe effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, BrasilCentro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, BrasilEscola Bahiana de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilEscola Bahiana de Medicina. Salvador, BA, BrasilCentro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, BrasilOBJECTIVE: To determine the effect of oral contraceptives containing gestodene on aromatase expression in the endometrium of patients diagnosed with endometriosis. PATIENTS AND METHODS: Endometrial biopsies were taken at the time of laparoscopy in 40 patients with endometriosis, 16 of whom were using an oral contraceptive containing gestodene at the time of laparoscopy. The remaining 24 patients were receiving no form of treatment for endometriosis. Endometrial biopsies taken from 23 patients with normal echographic signs and no symptoms were used as controls. Aromatase expression was evaluated in endometrial samples using immunohistochemistry. RESULTS: In the untreated, symptomatic endometriosis patients, aromatase expression was detected during the proliferative phase in 92% of cases, while in the symptom-free control patients aromatase was expressed in only 9% of cases. In patients with endometriosis who were using oral contraceptives, there were significantly fewer cases of positive endometria compared with the untreated patients with endometriosis (6%). CONCLUSION: Oral contraceptives containing gestodene are effective in decreasing aromatase expression in the eutopic endometrium of patients with endometriosis.EndometriumAromataseGestodeneEndometriosisMenstrual cycleAromatase/análiseAnticoncepcionais Orais/uso terapêuticoEndometriose/quimioterapiaEndometriose/enzimologiaEndométrio/enzimologiaAdultoAnticoncepcionais Orais Sintéticos/uso terapêuticoFemininoFase FolicularHumanosImuno-HistoquímicaNorpregnenos/uso terapêuticoEstudos Retrospectivosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMaia H Jr The effect of oral....pdfMaia H Jr The effect of oral....pdfapplication/pdf199531https://www.arca.fiocruz.br/bitstream/icict/7808/1/Maia%20H%20Jr%20The%20effect%20of%20oral....pdffaab419ea45ae41ac895eaf07f8a6849MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7808/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMaia H Jr The effect of oral....pdf.txtMaia H Jr The effect of oral....pdf.txtExtracted texttext/plain26757https://www.arca.fiocruz.br/bitstream/icict/7808/5/Maia%20H%20Jr%20The%20effect%20of%20oral....pdf.txt8e2ecc85b5c16d6681aed6bcad5e7283MD55THUMBNAILMaia H Jr The effect of oral....pdf.jpgMaia H Jr The effect of oral....pdf.jpgGenerated Thumbnailimage/jpeg2073https://www.arca.fiocruz.br/bitstream/icict/7808/4/Maia%20H%20Jr%20The%20effect%20of%20oral....pdf.jpgf206d8997eaf0221454fbb6f531229acMD54icict/78082023-03-15 14:33:15.963oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
title The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
spellingShingle The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
Maia Junior, Hugo
Endometrium
Aromatase
Gestodene
Endometriosis
Menstrual cycle
Aromatase/análise
Anticoncepcionais Orais/uso terapêutico
Endometriose/quimioterapia
Endometriose/enzimologia
Endométrio/enzimologia
Adulto
Anticoncepcionais Orais Sintéticos/uso terapêutico
Feminino
Fase Folicular
Humanos
Imuno-Histoquímica
Norpregnenos/uso terapêutico
Estudos Retrospectivos
title_short The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
title_full The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
title_fullStr The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
title_full_unstemmed The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
title_sort The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis.
author Maia Junior, Hugo
author_facet Maia Junior, Hugo
Casoy, Julio
Correia, Tania Maria
Freitas, Luiz Antonio Rodrigues de
Pimentel, Kleber
Athayde, Célia
author_role author
author2 Casoy, Julio
Correia, Tania Maria
Freitas, Luiz Antonio Rodrigues de
Pimentel, Kleber
Athayde, Célia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maia Junior, Hugo
Casoy, Julio
Correia, Tania Maria
Freitas, Luiz Antonio Rodrigues de
Pimentel, Kleber
Athayde, Célia
dc.subject.en.pt_BR.fl_str_mv Endometrium
Aromatase
Gestodene
Endometriosis
Menstrual cycle
topic Endometrium
Aromatase
Gestodene
Endometriosis
Menstrual cycle
Aromatase/análise
Anticoncepcionais Orais/uso terapêutico
Endometriose/quimioterapia
Endometriose/enzimologia
Endométrio/enzimologia
Adulto
Anticoncepcionais Orais Sintéticos/uso terapêutico
Feminino
Fase Folicular
Humanos
Imuno-Histoquímica
Norpregnenos/uso terapêutico
Estudos Retrospectivos
dc.subject.decs.pt_BR.fl_str_mv Aromatase/análise
Anticoncepcionais Orais/uso terapêutico
Endometriose/quimioterapia
Endometriose/enzimologia
Endométrio/enzimologia
Adulto
Anticoncepcionais Orais Sintéticos/uso terapêutico
Feminino
Fase Folicular
Humanos
Imuno-Histoquímica
Norpregnenos/uso terapêutico
Estudos Retrospectivos
description Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH). Salvador, BA, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-06-09T19:38:29Z
dc.date.available.fl_str_mv 2014-06-09T19:38:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAIA JUNIOR, H. et al. The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis. Gynecologyical Endocrinology, v. 24, n. 3, p. 123-128, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7808
dc.identifier.issn.none.fl_str_mv 0951-3590
dc.identifier.doi.none.fl_str_mv 10.1080/09513590801890816
identifier_str_mv MAIA JUNIOR, H. et al. The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis. Gynecologyical Endocrinology, v. 24, n. 3, p. 123-128, 2008.
0951-3590
10.1080/09513590801890816
url https://www.arca.fiocruz.br/handle/icict/7808
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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