Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis

Detalhes bibliográficos
Autor(a) principal: Ramirez, Aína Danaisa Ramirez
Data de Publicação: 2022
Outros Autores: Jesus, Myrela Conceição Santos de, Rossit, Júlia, Reis, Nathália Faria, Santos Filho, Marcelo Cerilo, Sudré, Adriana Pittella, Ferreira, Joseli de Oliveira, Baptista, Andrea Regina de Souza, Melo, Luciane Moreno Storti, Machado, Ricardo Luiz Dantas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53608
Resumo: Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.
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spelling Ramirez, Aína Danaisa RamirezJesus, Myrela Conceição Santos deRossit, JúliaReis, Nathália FariaSantos Filho, Marcelo CeriloSudré, Adriana PittellaFerreira, Joseli de OliveiraBaptista, Andrea Regina de SouzaMelo, Luciane Moreno StortiMachado, Ricardo Luiz Dantas2022-07-01T12:47:01Z2022-07-01T12:47:01Z2022RAMIREZ, Aína Danaisa Ramirez et al. Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis. Heliyon, v. 8, e09318, p. 1 - 8, Apr. 2022.2405-8440https://www.arca.fiocruz.br/handle/icict/5360810.1016/j.heliyon.2022.e09318engElsevierMaláriaPlasmodium falciparumPlasmodium vivaxTLRReceptores Toll-likePolimorfismoMalariaPlasmodium falciparumPlasmodium vivaxTLRPolymorphismToll-like receptorsAssociation of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil / Universidade Federal de Sergipe. Centro de Ciências Biológicas e da Saúde. Departamento de Biologia. Laboratório de Genética Molecular e Biotecnologia. São Cristovão, SE, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos, Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Biologia Molecular de Parasitas. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.Universidade Federal de Sergipe. Centro de Ciências Biológicas e da Saúde. Departamento de Biologia. Laboratório de Genética Molecular e Biotecnologia. São Cristovão, SE, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.Toll-like receptors (TLRs) play a key role in the induced immune response in malaria. Although the potential roles of TLRs have been described, it is necessary to elucidate which of these receptors may actually have an impact on the immunopathogenesis of the disease. This article performed a meta-analysis adhered to the PRISMA statement on TLRs studied in malaria by Plasmodium falciparum and Plasmodium vivax and its impact on susceptibility and pathogenesis during malaria. A search of the literature was undertaken in PubMed, LILACS and SciELO published until June 30th, 2020. The risk of bias was calculated using the Joanna Briggs Institute's Critical Review Checklist. Later, based on the inclusion and/or exclusion criteria, 17 out of 296 articles were harvested for this systematic review, the meta-analysis included studies incorporating 6,747 cases and 8,983 controls. The results showed that only TLR1, TLR9 and TLR4 receptors were associated with parasitemia, TLR2 and TLR6 were related with severity and none TLR was correlated with susceptibility. The data described here should be taken with caution, since the current evidence is limited and inconsistent. More studies are needed given that the results may change depending on the region and genetic background of the populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53608/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseliOFerreira_AinaRamirez_etal_IOC_2022.pdfJoseliOFerreira_AinaRamirez_etal_IOC_2022.pdfapplication/pdf2405010https://www.arca.fiocruz.br/bitstream/icict/53608/2/JoseliOFerreira_AinaRamirez_etal_IOC_2022.pdf80edffdbf0efb71dd4990819e6a69f6bMD52icict/536082022-07-01 09:47:01.643oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-07-01T12:47:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
title Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
spellingShingle Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
Ramirez, Aína Danaisa Ramirez
Malária
Plasmodium falciparum
Plasmodium vivax
TLR
Receptores Toll-like
Polimorfismo
Malaria
Plasmodium falciparum
Plasmodium vivax
TLR
Polymorphism
Toll-like receptors
title_short Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
title_full Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
title_fullStr Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
title_full_unstemmed Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
title_sort Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis
author Ramirez, Aína Danaisa Ramirez
author_facet Ramirez, Aína Danaisa Ramirez
Jesus, Myrela Conceição Santos de
Rossit, Júlia
Reis, Nathália Faria
Santos Filho, Marcelo Cerilo
Sudré, Adriana Pittella
Ferreira, Joseli de Oliveira
Baptista, Andrea Regina de Souza
Melo, Luciane Moreno Storti
Machado, Ricardo Luiz Dantas
author_role author
author2 Jesus, Myrela Conceição Santos de
Rossit, Júlia
Reis, Nathália Faria
Santos Filho, Marcelo Cerilo
Sudré, Adriana Pittella
Ferreira, Joseli de Oliveira
Baptista, Andrea Regina de Souza
Melo, Luciane Moreno Storti
Machado, Ricardo Luiz Dantas
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramirez, Aína Danaisa Ramirez
Jesus, Myrela Conceição Santos de
Rossit, Júlia
Reis, Nathália Faria
Santos Filho, Marcelo Cerilo
Sudré, Adriana Pittella
Ferreira, Joseli de Oliveira
Baptista, Andrea Regina de Souza
Melo, Luciane Moreno Storti
Machado, Ricardo Luiz Dantas
dc.subject.other.pt_BR.fl_str_mv Malária
Plasmodium falciparum
Plasmodium vivax
TLR
Receptores Toll-like
Polimorfismo
topic Malária
Plasmodium falciparum
Plasmodium vivax
TLR
Receptores Toll-like
Polimorfismo
Malaria
Plasmodium falciparum
Plasmodium vivax
TLR
Polymorphism
Toll-like receptors
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium falciparum
Plasmodium vivax
TLR
Polymorphism
Toll-like receptors
description Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Centro de Investigação de Microrganismos,. Niterói, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-07-01T12:47:01Z
dc.date.available.fl_str_mv 2022-07-01T12:47:01Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMIREZ, Aína Danaisa Ramirez et al. Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis. Heliyon, v. 8, e09318, p. 1 - 8, Apr. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53608
dc.identifier.issn.pt_BR.fl_str_mv 2405-8440
dc.identifier.doi.none.fl_str_mv 10.1016/j.heliyon.2022.e09318
identifier_str_mv RAMIREZ, Aína Danaisa Ramirez et al. Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis. Heliyon, v. 8, e09318, p. 1 - 8, Apr. 2022.
2405-8440
10.1016/j.heliyon.2022.e09318
url https://www.arca.fiocruz.br/handle/icict/53608
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53608/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53608/2/JoseliOFerreira_AinaRamirez_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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